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Tranexamic Acid in Gynaecology & Obstetrics
... severe kidney problems (kidney failure), patients who have or have had a blood clot in their blood vessels (thrombosis) particularly in the leg or lung, patients in whom a blood clot has caused a stroke, severe bruising, patients with family members who have had a blood clot in their blood vessels, ...
... severe kidney problems (kidney failure), patients who have or have had a blood clot in their blood vessels (thrombosis) particularly in the leg or lung, patients in whom a blood clot has caused a stroke, severe bruising, patients with family members who have had a blood clot in their blood vessels, ...
Thrombin = anticoagulant
... Head-to-head comparison between anti-IIa and anti-Xa inhibitors Even if we have a study which shows that the cost-benefit ratio is superior with one compound versus another one, this will be true : ...
... Head-to-head comparison between anti-IIa and anti-Xa inhibitors Even if we have a study which shows that the cost-benefit ratio is superior with one compound versus another one, this will be true : ...
PDF hosted at the Radboud Repository of the Radboud University
... Although synthetic histone deacetylases inhibitors (HDACi) hyperacetylate histones via the conserved N-terminal lysines present on histones, they also hyperacetylate cytoplasmic proteins, including transcription factors. Therefore, unraveling chromatin and thus permitting transcription factors to bi ...
... Although synthetic histone deacetylases inhibitors (HDACi) hyperacetylate histones via the conserved N-terminal lysines present on histones, they also hyperacetylate cytoplasmic proteins, including transcription factors. Therefore, unraveling chromatin and thus permitting transcription factors to bi ...
Single-Dose Administration of Bowman
... when animals were fed raw soybeans (27). This was erroneously attributed to protease inhibitors (1, 22). Pancreatic changes are a potential toxicity concern because they have been associated with trypsin inhibition in rats fed very high levels of soybeans over long periods of time (28, 29). BBI cont ...
... when animals were fed raw soybeans (27). This was erroneously attributed to protease inhibitors (1, 22). Pancreatic changes are a potential toxicity concern because they have been associated with trypsin inhibition in rats fed very high levels of soybeans over long periods of time (28, 29). BBI cont ...
Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis
... candidates like OZ439 [12]. In addition, the global malaria agenda has shifted from the mere control of clinical cases to malaria elimination and eventually eradication urgently requiring transmission blocking agents [13]. Human African trypanosomiasis (HAT), also known as sleeping sickness, is caus ...
... candidates like OZ439 [12]. In addition, the global malaria agenda has shifted from the mere control of clinical cases to malaria elimination and eventually eradication urgently requiring transmission blocking agents [13]. Human African trypanosomiasis (HAT), also known as sleeping sickness, is caus ...
Structure-based drug design meets the ribosome
... rapidly, in both, hospital and community settings [1]. Yearly, approximately 90,000 hospital patients in the United States die as a result of a bacterial infection. This death rate increased almost an order of magnitude since 1992, when it was 13,300 [1]. In over 70% of these bacterial infections, t ...
... rapidly, in both, hospital and community settings [1]. Yearly, approximately 90,000 hospital patients in the United States die as a result of a bacterial infection. This death rate increased almost an order of magnitude since 1992, when it was 13,300 [1]. In over 70% of these bacterial infections, t ...
Antifungals
... safety of lipid based amphotericin B preparations? Leuk Res. 1997;21:183-188. Groll AH et al. Penetration of lipid formulations of amphotericin B into cerebral fluid and brain tissue. 37th ICAAC, 1997. Abstract A90. Gallagher JC et al. Recent advances in antifungal pharmacotherapy for invasive funga ...
... safety of lipid based amphotericin B preparations? Leuk Res. 1997;21:183-188. Groll AH et al. Penetration of lipid formulations of amphotericin B into cerebral fluid and brain tissue. 37th ICAAC, 1997. Abstract A90. Gallagher JC et al. Recent advances in antifungal pharmacotherapy for invasive funga ...
Memorin - Beximco Pharmaceuticals Ltd.
... mg/kg/day (approximately 13 times the maximum recommended human dose on a mg/m2 basis) and in pregnant rabbits at doses up to 10 mg/kg/day (approximately 16 times the maximum recommended human dose on a mg/m2 basis) did not disclose any evidence for a teratogenic potential of donepezil. However, in ...
... mg/kg/day (approximately 13 times the maximum recommended human dose on a mg/m2 basis) and in pregnant rabbits at doses up to 10 mg/kg/day (approximately 16 times the maximum recommended human dose on a mg/m2 basis) did not disclose any evidence for a teratogenic potential of donepezil. However, in ...
Overview of Vinca Alkaloids
... by forming linear protofilaments Microtubules are composed of 13 protofilaments aligned side-by-side around a hollow core with α- and β-tubulin subunits alternating with each other ...
... by forming linear protofilaments Microtubules are composed of 13 protofilaments aligned side-by-side around a hollow core with α- and β-tubulin subunits alternating with each other ...
L23-24-25 Alkaloids Medicinal Plants
... Tubocurarine : is a benzyl tetrahydrquinoline alkaloids, by phenolic oxidation, an ether linkage will be formed between the 2 monomers, notice there could be 2 identical (R+R), (S+S) or (R+S) norcoclaurine molecules involved in the structure. Notice the presence of the mono quaternary (positively ch ...
... Tubocurarine : is a benzyl tetrahydrquinoline alkaloids, by phenolic oxidation, an ether linkage will be formed between the 2 monomers, notice there could be 2 identical (R+R), (S+S) or (R+S) norcoclaurine molecules involved in the structure. Notice the presence of the mono quaternary (positively ch ...
IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.
... Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to th ...
... Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to th ...
Kr_01 - HIV-NAT
... VL q 6 mo, until VL<50, then q 1 yr CD4: q 6 mo, until CD4 >350, q 1 yr Resistance ...
... VL q 6 mo, until VL<50, then q 1 yr CD4: q 6 mo, until CD4 >350, q 1 yr Resistance ...
A Review of Sodium Glucose Co transporter 2 (SGLT2)
... SGLT2 inhibitors have demonstrated efficacy and safety in clinical trials for the treatment of patients with T2DM [1225]. SGLT2 inhibitors as monotherapy or in combination with another anti-diabetic treatment such as metformin or sulfonylurea have demonstrated efficacy in glycemic control with HgA1c ...
... SGLT2 inhibitors have demonstrated efficacy and safety in clinical trials for the treatment of patients with T2DM [1225]. SGLT2 inhibitors as monotherapy or in combination with another anti-diabetic treatment such as metformin or sulfonylurea have demonstrated efficacy in glycemic control with HgA1c ...
Rifampicin Antagonizes the Effect of Chloroquine on Chloroquine
... efficacy of malaria chemotherapy and perhaps new combination treatment strategies to prevent or reverse CQ resistance in malaria. However, the effect of RIF in combination with CQ has not been studied against CQ-resistant Plasmodium spp. either in vitro (cell line) or in vivo. Therefore, we studied ...
... efficacy of malaria chemotherapy and perhaps new combination treatment strategies to prevent or reverse CQ resistance in malaria. However, the effect of RIF in combination with CQ has not been studied against CQ-resistant Plasmodium spp. either in vitro (cell line) or in vivo. Therefore, we studied ...
Gram-Negative
... allergic patients • Infections caused by multidrug resistant bacteria • Endocarditis or surgical prophylaxis in select cases ...
... allergic patients • Infections caused by multidrug resistant bacteria • Endocarditis or surgical prophylaxis in select cases ...
GATE 2009 Pharmaceutical Sciences Question Paper
... Genetically modified species of Papaver namely Papaver bracteatum and Papaver orient ale contain the predominant alkaloid (A) ...
... Genetically modified species of Papaver namely Papaver bracteatum and Papaver orient ale contain the predominant alkaloid (A) ...
Study of the Pepsin Enzymatic Activity in in
... edition Brazilian Pharmacopoeia, monograph no. 180.1 from ANVISA. Vankel VK 7000, apparatus 2 (paddle), temperature of 37.0 °C and stirring speed of 50 rpm were used. The dissolution medium was simulated gastric fluid with pepsin, which was prepared with 2 g of sodium chloride, varying concentration ...
... edition Brazilian Pharmacopoeia, monograph no. 180.1 from ANVISA. Vankel VK 7000, apparatus 2 (paddle), temperature of 37.0 °C and stirring speed of 50 rpm were used. The dissolution medium was simulated gastric fluid with pepsin, which was prepared with 2 g of sodium chloride, varying concentration ...
this PDF file - Innovare Academic Sciences
... was significantly different when compared with controls (p<0.05), as well as water fraction dose of 3.5 mg/kg bw and a dose of 75 mg/kg bw, while the ethyl acetate fraction of all doses significantly different when compared with the control group (p<0.05). This shows that the extract or fractions ro ...
... was significantly different when compared with controls (p<0.05), as well as water fraction dose of 3.5 mg/kg bw and a dose of 75 mg/kg bw, while the ethyl acetate fraction of all doses significantly different when compared with the control group (p<0.05). This shows that the extract or fractions ro ...
2 review of literature 28.06.2013
... untoward side effects. Emergence of drug resistance in pathogens against commonly used drugs has warranted an urgent need to develop new and safe drug with an alternate mode of action. Despite the introduction of allopathic medicines plant based medicines are much in demand. The compounds isolated f ...
... untoward side effects. Emergence of drug resistance in pathogens against commonly used drugs has warranted an urgent need to develop new and safe drug with an alternate mode of action. Despite the introduction of allopathic medicines plant based medicines are much in demand. The compounds isolated f ...
Thymidylate Synthase Inhibitors
... no conclusive evidence for cooperativity between monomers. However, ligand binding is associated with large conformational changes and involves most of the domains of the protein. Thus, the liganded state at both active sites will play a role in ligand affinity (34). Binding studies using equilibriu ...
... no conclusive evidence for cooperativity between monomers. However, ligand binding is associated with large conformational changes and involves most of the domains of the protein. Thus, the liganded state at both active sites will play a role in ligand affinity (34). Binding studies using equilibriu ...
The Expanding Role of Microsomal Enzyme Induction, and Its
... Microsomal enzyme induction, a term denoting the ability of the substrate for a microsomal enzyme to enhance the activity of that enzyme and frequently of related enzymes, has been demonstratQd in a wide range of tissues, notably the liver, placenta, small intestinal mucosa, and peripheral lymphocyt ...
... Microsomal enzyme induction, a term denoting the ability of the substrate for a microsomal enzyme to enhance the activity of that enzyme and frequently of related enzymes, has been demonstratQd in a wide range of tissues, notably the liver, placenta, small intestinal mucosa, and peripheral lymphocyt ...
Potency of Kara sooda sathu parpam, a herbo mineral siddha drug
... crystals containing small amounts of proteins and glycoproteins. Different types occur with different frequencies in different parts of the world, probably as a consequence of dietary and environmental factors, but genetic factors may also make a significant contribution4. Urolithiasis is a recurren ...
... crystals containing small amounts of proteins and glycoproteins. Different types occur with different frequencies in different parts of the world, probably as a consequence of dietary and environmental factors, but genetic factors may also make a significant contribution4. Urolithiasis is a recurren ...