Emerging Treatment for Hypersomnolence
... • Clinical anecdote of a patient with GABArelated hypersomnia who developed severe insomnia when given the drug for bronchitis • Known CNS side effects (insomnia, mania) • Acts as a GABA antagonist in vitro – (Garcia and Jenkins 2009) ...
... • Clinical anecdote of a patient with GABArelated hypersomnia who developed severe insomnia when given the drug for bronchitis • Known CNS side effects (insomnia, mania) • Acts as a GABA antagonist in vitro – (Garcia and Jenkins 2009) ...
Opioid Metabolism
... Metabolism refers to the process of biotransformation by which drugs are broken down so that they can be eliminated by the body. Some drugs perform their functions and then are excreted from the body intact, but many require metabolism to enable them to reach their target site in an appropriate amou ...
... Metabolism refers to the process of biotransformation by which drugs are broken down so that they can be eliminated by the body. Some drugs perform their functions and then are excreted from the body intact, but many require metabolism to enable them to reach their target site in an appropriate amou ...
Bioidentical Hormone Therapy
... prescribed contain 2 or 3 forms of estrogen that are “identical” to those found in humans: estradiol, estrone, and estriol in varying percentages. Common CBHT preparations are listed in Table 2. Although the compounded drug biestrogen (bi-est) is composed primarily (80%) of estriol, 17β-estradiol ac ...
... prescribed contain 2 or 3 forms of estrogen that are “identical” to those found in humans: estradiol, estrone, and estriol in varying percentages. Common CBHT preparations are listed in Table 2. Although the compounded drug biestrogen (bi-est) is composed primarily (80%) of estriol, 17β-estradiol ac ...
Full text in pdf format
... arthropods. Ingestion of high doses causes ovigerous American lobsters Homarus americanus to molt before their eggs hatch. To determine the effect of repeated exposure to doses at or below the noobserved-effect level (NOEL) of a single exposure (NOEL: 0.12 µg g–1), ovigerous lobsters were given eith ...
... arthropods. Ingestion of high doses causes ovigerous American lobsters Homarus americanus to molt before their eggs hatch. To determine the effect of repeated exposure to doses at or below the noobserved-effect level (NOEL) of a single exposure (NOEL: 0.12 µg g–1), ovigerous lobsters were given eith ...
hMg-CoA-reductase inhibitors and neuropathy: reports to the
... inhibitors to reduce cholesterol levels in the framework of the primary and secondary prevention of atherosclerosis. Furthermore, HMG-CoA-reductase inhibitors reduce the risk of stroke and peripheral vascular disorders.1 The Heart Protection Study showed a significant reduction in the risk of cardio ...
... inhibitors to reduce cholesterol levels in the framework of the primary and secondary prevention of atherosclerosis. Furthermore, HMG-CoA-reductase inhibitors reduce the risk of stroke and peripheral vascular disorders.1 The Heart Protection Study showed a significant reduction in the risk of cardio ...
all about salvia divinorum
... The Mazatec curanderos use S. divinorum (which they call las hojas de la Maria Pastora -- the leaves of Mary the Shepherdess) both as a hallucinogen and a general healing herb. When used as a hallucinogen, one of three methods are used: chewi ng a quid of leaves, smoking, and drinking an infusion. W ...
... The Mazatec curanderos use S. divinorum (which they call las hojas de la Maria Pastora -- the leaves of Mary the Shepherdess) both as a hallucinogen and a general healing herb. When used as a hallucinogen, one of three methods are used: chewi ng a quid of leaves, smoking, and drinking an infusion. W ...
Drug Information Letter New Drug Evaluation Multaq (dronedarone) Tablets
... placebo group (3.8%) had died. This is more than double the amount of deaths versus placebo. The main reason for death was worsening heart failure. Contrasting ANDROMEDA5 and ATHENA1 The ANDROMEDA and ATHENA populations differed markedly. In ANDROMEDA, the majority of patients had either NYHA Class ...
... placebo group (3.8%) had died. This is more than double the amount of deaths versus placebo. The main reason for death was worsening heart failure. Contrasting ANDROMEDA5 and ATHENA1 The ANDROMEDA and ATHENA populations differed markedly. In ANDROMEDA, the majority of patients had either NYHA Class ...
The analgesic and anticonvulsant effects of piperine in mice
... Piperine, is the major active principal of black pepper. In traditional medicine, black pepper has been used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy. This study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice. The analg ...
... Piperine, is the major active principal of black pepper. In traditional medicine, black pepper has been used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy. This study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice. The analg ...
1 Benfotiamine: possibility for implication to cancer chemotherapy
... The results from the in vitro cytotoxicity assay were analyzed, using the Student’s t-test with p<0.05 taken as significance level. The data from in vivo tests were analyzed using both absolute response latency values (increase over pre-drug latency) as well as per cent of the maximum possible effec ...
... The results from the in vitro cytotoxicity assay were analyzed, using the Student’s t-test with p<0.05 taken as significance level. The data from in vivo tests were analyzed using both absolute response latency values (increase over pre-drug latency) as well as per cent of the maximum possible effec ...
a review on technologies, recent trends and regulatory aspects
... phenylketonuria and contra-indicated in homozygous autosomal recessive patients [14].Rare hypersensitivity reactions have been reported. Cross-reactivity with sulfonamides can occur. Flavouring Agents Flavour is a complex effect of three components taste, odor and feeling factors [16].Suitable flavo ...
... phenylketonuria and contra-indicated in homozygous autosomal recessive patients [14].Rare hypersensitivity reactions have been reported. Cross-reactivity with sulfonamides can occur. Flavouring Agents Flavour is a complex effect of three components taste, odor and feeling factors [16].Suitable flavo ...
Sulphonylurea A Golden Therapy For Diabetes
... Glimepiride does not block the beneficial cardioprotective effect of ischemic preconditioning ...
... Glimepiride does not block the beneficial cardioprotective effect of ischemic preconditioning ...
Forensic Toxicology: General Consideration By
... drugs are well tolerated, like, in case of strychnine poisoning, barbiturates and sedatives are better tolerated. Whereas in case of barbiturate poisoning any sedative or tranquilizer will accentuate the process of death. 11. Sleep - Due to slow metabolic process and depression of other body functio ...
... drugs are well tolerated, like, in case of strychnine poisoning, barbiturates and sedatives are better tolerated. Whereas in case of barbiturate poisoning any sedative or tranquilizer will accentuate the process of death. 11. Sleep - Due to slow metabolic process and depression of other body functio ...
Rifampicin Antagonizes the Effect of Chloroquine on Chloroquine
... studied for the effect of CQ versus the combination of CQ + RIF at various doses on the clearance of parasitemia, the survival of the mice, and the recrudescence of malaria. Paradoxically, RIF decreased the survival rate and rate of clearance of parasitemia and increased the rate of recrudescence si ...
... studied for the effect of CQ versus the combination of CQ + RIF at various doses on the clearance of parasitemia, the survival of the mice, and the recrudescence of malaria. Paradoxically, RIF decreased the survival rate and rate of clearance of parasitemia and increased the rate of recrudescence si ...
Report of the International Narcotics Control Board for 2015
... the control of the international licit trade in narcotic drugs, psychotropic substances and precursors has been an undeniable success, as today no noteworthy diversion of those substances from licit to illicit channels is taking place. On the other hand, the availability and accessibility of narcoti ...
... the control of the international licit trade in narcotic drugs, psychotropic substances and precursors has been an undeniable success, as today no noteworthy diversion of those substances from licit to illicit channels is taking place. On the other hand, the availability and accessibility of narcoti ...
PDF - Medical Journal of Australia
... safety, efficacy and cost-effectiveness of PAT in speeding rehabilitation from severe catabolic injury (burns, critical illness or major surgery) and chronic organ failure states for which there is promising but inconclusive evidence. Key considerations for clinical research in PAT include distingui ...
... safety, efficacy and cost-effectiveness of PAT in speeding rehabilitation from severe catabolic injury (burns, critical illness or major surgery) and chronic organ failure states for which there is promising but inconclusive evidence. Key considerations for clinical research in PAT include distingui ...
Medical Cannabis Toolkit
... Epidiolex® cannabidiol – Pharmaceutical grade CBD preparation currently in clinical studies Sativex ® nabiximols (THC:CBD in a 1:1 ratio) – approved in several; countries for the treatment of pain and spasticity associated with multiple sclerosis. In Phase III FDA trials and is expected to be approv ...
... Epidiolex® cannabidiol – Pharmaceutical grade CBD preparation currently in clinical studies Sativex ® nabiximols (THC:CBD in a 1:1 ratio) – approved in several; countries for the treatment of pain and spasticity associated with multiple sclerosis. In Phase III FDA trials and is expected to be approv ...
Book of abstracts
... Israel Institute of Technology, Haifa, Israel Common knowledge and extensive scientific evidence suggest that the brain affects the immune system. This relationship is manifested by responses such as increased disease prevalence following stress or cure following treatment with a placebo pill. Altho ...
... Israel Institute of Technology, Haifa, Israel Common knowledge and extensive scientific evidence suggest that the brain affects the immune system. This relationship is manifested by responses such as increased disease prevalence following stress or cure following treatment with a placebo pill. Altho ...
The Role of Intrathecal Drugs in the Treatment of Acute Pain
... morphine ranging from 0 –300 g after total hip and knee arthroplasty. After total hip replacement, intrathecal morphine (200 g) provided excellent analgesia. In contrast, the degree of pain experienced after total knee arthroplasty exceeded the analgesia afforded by even the largest dose of intrat ...
... morphine ranging from 0 –300 g after total hip and knee arthroplasty. After total hip replacement, intrathecal morphine (200 g) provided excellent analgesia. In contrast, the degree of pain experienced after total knee arthroplasty exceeded the analgesia afforded by even the largest dose of intrat ...
The Handbook of Clinically Tested Herbal Remedies
... “Phytomedicines: Back to the Future” In Journal of Natural Products Background of the Project The genesis of the idea for this book came from a conversation with my childhood physician, Larry Posner, MD, at a party in September 1998. He told me of his interest in botanicals due to the number of pati ...
... “Phytomedicines: Back to the Future” In Journal of Natural Products Background of the Project The genesis of the idea for this book came from a conversation with my childhood physician, Larry Posner, MD, at a party in September 1998. He told me of his interest in botanicals due to the number of pati ...
Evolution of medical treatment for endometriosis: back to the roots?
... Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and painalleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of ...
... Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and painalleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of ...
Predictive validity of a non-induced mouse model of
... used for a nest in high (BIG) and low (SMALL) selected lines. The nesting behavior of BIG mice appears to be compulsive-like and has initial face validity as an animal model for OCD in humans. Compulsive-like digging behavior was assessed; BIG male mice buried about three times as many marbles as SM ...
... used for a nest in high (BIG) and low (SMALL) selected lines. The nesting behavior of BIG mice appears to be compulsive-like and has initial face validity as an animal model for OCD in humans. Compulsive-like digging behavior was assessed; BIG male mice buried about three times as many marbles as SM ...
Learning objectives
... simple - does not impair awareness (eg. epileptic auras, jacksonian march) complex - impairs awareness by typically spreading to one or both temporal lobes secondarily generalized - when simple type spreads to involve both hemispheres diffusely ...
... simple - does not impair awareness (eg. epileptic auras, jacksonian march) complex - impairs awareness by typically spreading to one or both temporal lobes secondarily generalized - when simple type spreads to involve both hemispheres diffusely ...
Neuromuscular Blockade in Patients with Myasthenia Gravis (MG)
... Ocular symptoms only or mild weakness cholinesterase inhibitors Moderate to severe weakness cholinesterase inhibitors and thymectomy for pts <60 yo Uncontrolled symptoms w/ cholinesterase inhibitors immunosuppression ...
... Ocular symptoms only or mild weakness cholinesterase inhibitors Moderate to severe weakness cholinesterase inhibitors and thymectomy for pts <60 yo Uncontrolled symptoms w/ cholinesterase inhibitors immunosuppression ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.