Cocaine-Like Discriminative Stimulus Effects of
... interactions with monoamine transporters, where smaller compounds (e.g., mephedrone) are amphetamine-like monoamine releasers, while the structurally larger compounds (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors. Individual cathinones also differ from one another with respect to ...
... interactions with monoamine transporters, where smaller compounds (e.g., mephedrone) are amphetamine-like monoamine releasers, while the structurally larger compounds (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors. Individual cathinones also differ from one another with respect to ...
Ethylone Critical Review Report
... T+0:00 - 200 milligrams of Ethylone (bk-MDEA) is consumed via oral administration. My most recent meal was consumed approximately 3 hours prior. T+0:45 - My body feels lighter, a bit of muscle tension in my neck though not related to the compound, a heightening of senses definitely makes the sensati ...
... T+0:00 - 200 milligrams of Ethylone (bk-MDEA) is consumed via oral administration. My most recent meal was consumed approximately 3 hours prior. T+0:45 - My body feels lighter, a bit of muscle tension in my neck though not related to the compound, a heightening of senses definitely makes the sensati ...
Psychobiological risk factors for vulnerability to psychostimulants in
... start with tobacco and/or alcohol, followed by marijuana, and eventually psychostimulants and/or opiates (see Ref. [7]). Adolescent involvement with drugs seems to be multiply determined: exposure to a higher number of risk factors is not only a reliable correlate of drug use, but it also increases ...
... start with tobacco and/or alcohol, followed by marijuana, and eventually psychostimulants and/or opiates (see Ref. [7]). Adolescent involvement with drugs seems to be multiply determined: exposure to a higher number of risk factors is not only a reliable correlate of drug use, but it also increases ...
The serotonin RECEPTOR antagonists NAN
... Some aspects of locomotor activity and the stereotyped behavior induced by methamphetamine, a known drug of abuse worldwide, are probably a consequence of the release of dopamine from dopaminergic nerve terminals, particularly in the neostriatum. With higher doses of methamphetamine, disturbances of ...
... Some aspects of locomotor activity and the stereotyped behavior induced by methamphetamine, a known drug of abuse worldwide, are probably a consequence of the release of dopamine from dopaminergic nerve terminals, particularly in the neostriatum. With higher doses of methamphetamine, disturbances of ...
... given with II-blockers. Observe patients treated with bottl agents closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/ presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been repo ...
Hallucinogens - LSD, Peyote, Psilocybin, and PCP
... Hallucinogenic compounds found in some plants and mushrooms (or their extracts) have been used—mostly during religious rituals—for centuries. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of natural neurotransm ...
... Hallucinogenic compounds found in some plants and mushrooms (or their extracts) have been used—mostly during religious rituals—for centuries. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of natural neurotransm ...
Lecture Power Point
... • Stimulants act on the brain to increase alertness and motor activity – Amphetamines release norepinephrine and dopamine in brain to produce alertness and to reduce appetite • Tolerance quickly develops to amphetamine use ...
... • Stimulants act on the brain to increase alertness and motor activity – Amphetamines release norepinephrine and dopamine in brain to produce alertness and to reduce appetite • Tolerance quickly develops to amphetamine use ...
Q10 Compare and contrast the mechanism of
... contractility). Indirect effects include release of ACh at cardiac muscarinic receptors resulting in bradycardia and further increase in the refractory period of the AV node. The slowing in conduction improve ...
... contractility). Indirect effects include release of ACh at cardiac muscarinic receptors resulting in bradycardia and further increase in the refractory period of the AV node. The slowing in conduction improve ...
Document
... Almost half of the drugs on the market act on GPCRs, which remain the most attractive target class for pharmaceutical and many biotech companies; especially peptide GPCRs are deemed promising drug targets. GPCRs are also promising targets for the development of new biodegradable, safe, specific and ...
... Almost half of the drugs on the market act on GPCRs, which remain the most attractive target class for pharmaceutical and many biotech companies; especially peptide GPCRs are deemed promising drug targets. GPCRs are also promising targets for the development of new biodegradable, safe, specific and ...
“Wiring” Your Brain - Scholastic Heads Up
... a devastating disease that affects millions of lives. ...
... a devastating disease that affects millions of lives. ...
pharmacokinetics - Dr. Brahmbhatt`s Class Handouts
... • The time elapsed from the time of administration to the time that the peak plasma level is reached is known as the time to peak – Important in making clinical judgments about the use of a drug • From the peak plasma level the concentration declines since the amount of drug being eliminated exceeds ...
... • The time elapsed from the time of administration to the time that the peak plasma level is reached is known as the time to peak – Important in making clinical judgments about the use of a drug • From the peak plasma level the concentration declines since the amount of drug being eliminated exceeds ...
GLP-1 Receptor Agonist - Canadian Diabetes Guidelines
... You develop any severe side effects and any negative changes in your overall health talk to your health care provider ...
... You develop any severe side effects and any negative changes in your overall health talk to your health care provider ...
heart failure
... failure due to LV dysfunction and should be used in conjunction with diuretics, ACE inhibitors and beta-blockers. Also recommended in patients with heart failure who have atrial fibrillation. Digoxin initiated and maintained at a dose of 0.25 mg daily. It cause inhibition of Na/K-ATPas &also caused ...
... failure due to LV dysfunction and should be used in conjunction with diuretics, ACE inhibitors and beta-blockers. Also recommended in patients with heart failure who have atrial fibrillation. Digoxin initiated and maintained at a dose of 0.25 mg daily. It cause inhibition of Na/K-ATPas &also caused ...
Company Profile
... Stimulating phagocytosis has the potential to clear alpha-synuclein, a known disease-causing molecule that accumulates in the brains of Parkinson’s patients. Recent studies also point to the importance of inflammation contributing to Parkinson’s disease. Anti-inflammatory effects of GC021109, or rel ...
... Stimulating phagocytosis has the potential to clear alpha-synuclein, a known disease-causing molecule that accumulates in the brains of Parkinson’s patients. Recent studies also point to the importance of inflammation contributing to Parkinson’s disease. Anti-inflammatory effects of GC021109, or rel ...
Antiarrhythmic Drugs
... acetylcholine sensitive K + channels and inhibition of calcium current. Atrioventricular nodal conduction and the atrioventricular nodal refractory period. It is drug of choice (DOC) for conversion of paroxysmal supraventricular tachycardia to sinus rhythm. High efficacy (90–95%) and very short dura ...
... acetylcholine sensitive K + channels and inhibition of calcium current. Atrioventricular nodal conduction and the atrioventricular nodal refractory period. It is drug of choice (DOC) for conversion of paroxysmal supraventricular tachycardia to sinus rhythm. High efficacy (90–95%) and very short dura ...
The Truth About Painkillers - Drug
... surface until it is too late. In 2007, for example, abuse of the painkiller Fentanyl killed more than 1,000 people. The drug was found to be 30 to 50 times more powerful than heroin. ...
... surface until it is too late. In 2007, for example, abuse of the painkiller Fentanyl killed more than 1,000 people. The drug was found to be 30 to 50 times more powerful than heroin. ...
alprazolam prescribing guidelines
... Alprazolam may cause drowsiness and affect alertness. Ideally it should only be taken for short periods of time such as 2 to 4 weeks. Benzodiazepines are very effective for treating acute symptoms,butif short acting benzodiazepines such as alprazolarn are used long term, the intended effect diminish ...
... Alprazolam may cause drowsiness and affect alertness. Ideally it should only be taken for short periods of time such as 2 to 4 weeks. Benzodiazepines are very effective for treating acute symptoms,butif short acting benzodiazepines such as alprazolarn are used long term, the intended effect diminish ...
OPIOIDS
... prescribing opiates for pain became more common during the last decade of the 20th Century • Opioid therapy became accepted (although often inadequately) for treating acute pain, pain due to cancer, & pain caused by a terminal disease • Still disputed is the use of opioids for chronic pain not assoc ...
... prescribing opiates for pain became more common during the last decade of the 20th Century • Opioid therapy became accepted (although often inadequately) for treating acute pain, pain due to cancer, & pain caused by a terminal disease • Still disputed is the use of opioids for chronic pain not assoc ...
Lesson 7 Molecules: Student notes
... have an enzyme that alters heroin and turns it into morphine. Recall that the acetyl groups on heroin enable this drug to pass into the brain very efficiently. But the acetyls must be removed before the drug can bind to opiate receptors. So, in most people, an enzyme attaches to the heroin and remov ...
... have an enzyme that alters heroin and turns it into morphine. Recall that the acetyl groups on heroin enable this drug to pass into the brain very efficiently. But the acetyls must be removed before the drug can bind to opiate receptors. So, in most people, an enzyme attaches to the heroin and remov ...
Absorption, distribution, metabolism and excretion
... to entry (skin, gut wall, alviolar membrane…..) are distributed by the blood to the site of action - intra- or extracellular - cross barriers to distribution (capillaries, cell wall….) - distribution affects concentration at site of action and sites of excretion and biotransformation are biotransfor ...
... to entry (skin, gut wall, alviolar membrane…..) are distributed by the blood to the site of action - intra- or extracellular - cross barriers to distribution (capillaries, cell wall….) - distribution affects concentration at site of action and sites of excretion and biotransformation are biotransfor ...
a to z guide of illicit and licit drugs
... Alcohol use is second only to tobacco as the leading preventable cause of death and hospitalisation and excessive consumption is associated with significant levels of harm and increased risk for a multitude of physical diseases including forms of cancer, liver cirrhosis, cardiovascular disease and p ...
... Alcohol use is second only to tobacco as the leading preventable cause of death and hospitalisation and excessive consumption is associated with significant levels of harm and increased risk for a multitude of physical diseases including forms of cancer, liver cirrhosis, cardiovascular disease and p ...
administering-medications-7th-edition-donna-gauwitz
... You are admitting a patient who frequently changes physicians. The patient has an unlabeled bottle of pills that she has been taking. She says that a doctor she no longer sees prescribed them for her. She does not know why she was taking the drug or the name of the drug. What should you do to determ ...
... You are admitting a patient who frequently changes physicians. The patient has an unlabeled bottle of pills that she has been taking. She says that a doctor she no longer sees prescribed them for her. She does not know why she was taking the drug or the name of the drug. What should you do to determ ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.