Buprenorphine Bluefish sublingual tablet ENG SmPC
... Alcohol increases the sedative effect of buprenorphine which will impair the ability to drive or use machinery. Buprenorphine Bluefish should not be taken together with alcoholic drinks or medicines containing alcohol. The following combinations should be used with precaution: Benzodiazepines: This ...
... Alcohol increases the sedative effect of buprenorphine which will impair the ability to drive or use machinery. Buprenorphine Bluefish should not be taken together with alcoholic drinks or medicines containing alcohol. The following combinations should be used with precaution: Benzodiazepines: This ...
PRODUCT MONOGRAPH PrZOLOFT® (sertraline hydrochloride) 25
... The mechanism of action of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most cl ...
... The mechanism of action of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most cl ...
Drug Metabolism Test Results
... factor: consider avoiding estrogen contraception and hormone replacement therapy. Women with no history of thrombotic events: consider informing on the risk of estrogen-containing contraceptives; consider alternative forms of contraception and control of menopausal symptoms. Women electing to use or ...
... factor: consider avoiding estrogen contraception and hormone replacement therapy. Women with no history of thrombotic events: consider informing on the risk of estrogen-containing contraceptives; consider alternative forms of contraception and control of menopausal symptoms. Women electing to use or ...
Hepatitis C Drug Development - HIV Research Catalyst Forum
... (fever, aches, nausea, appetite loss, weakness, & fatigue) Lab Abnormalities (anemia, neutropenia, thrombocytopenia) Neuropsychiatric (suicidal ideation/suicide (rare), depression, insomnia, anxiety, irritability, mood swings, mania, psychosis) Other (hair loss, optic nerve damage) ...
... (fever, aches, nausea, appetite loss, weakness, & fatigue) Lab Abnormalities (anemia, neutropenia, thrombocytopenia) Neuropsychiatric (suicidal ideation/suicide (rare), depression, insomnia, anxiety, irritability, mood swings, mania, psychosis) Other (hair loss, optic nerve damage) ...
Manipulation of the Rumen Microbial Environment to Improve
... the attention of researchers towards a new menace, Escherichia coli O157:H7. Increased foodborne illnesses due to this foodborne pathogen coupled with the fact that ruminants are the primary reservoir fueled recent research efforts to reduce pathogen shedding by cattle. Lastly, the debate over the ...
... the attention of researchers towards a new menace, Escherichia coli O157:H7. Increased foodborne illnesses due to this foodborne pathogen coupled with the fact that ruminants are the primary reservoir fueled recent research efforts to reduce pathogen shedding by cattle. Lastly, the debate over the ...
Curriculum - TARGET Center
... dependence. State of physical adaptation that is manifested by a drug class-specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, and/or decreasing blood level of a substance and/or administration of an antagonist. Dependence includes increased tolerance (see b ...
... dependence. State of physical adaptation that is manifested by a drug class-specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, and/or decreasing blood level of a substance and/or administration of an antagonist. Dependence includes increased tolerance (see b ...
Artemisia annua (Asteraceae) Description of the plant Plant parts
... artemisinin was administered to two groups of 4 male and 4 female dogs at 8 daily doses of 0, 20, 40, and 80 mg/kg intramuscularly or in contrast 0, 50, 150, and 600 mg/kg per os. Neurological signs were seen only at high intramuscular doses. In most animals the signs were inspicuous and consisted i ...
... artemisinin was administered to two groups of 4 male and 4 female dogs at 8 daily doses of 0, 20, 40, and 80 mg/kg intramuscularly or in contrast 0, 50, 150, and 600 mg/kg per os. Neurological signs were seen only at high intramuscular doses. In most animals the signs were inspicuous and consisted i ...
- Seminars in Nephrology
... Summary: Blood pressure targets and medications that are safe differ in pregnant women compared with nonpregnant individuals. The principles of treatment for mild, moderate, and severe hypertension in pregnancy, chronic versus gestational versus preeclampsia, and women hypertensive at term versus re ...
... Summary: Blood pressure targets and medications that are safe differ in pregnant women compared with nonpregnant individuals. The principles of treatment for mild, moderate, and severe hypertension in pregnancy, chronic versus gestational versus preeclampsia, and women hypertensive at term versus re ...
Risk Management Plan Rasagiline tablets
... antidepressants and MAO inhibitors. Therefore, in view of the MAO inhibitory activity of rasagiline, antidepressants should be administered with caution”; “In vitro metabolism studies have indicated that cytochrome P450 1A2 (CYP1A2) is the major enzyme responsible for the metabolism of rasagiline. C ...
... antidepressants and MAO inhibitors. Therefore, in view of the MAO inhibitory activity of rasagiline, antidepressants should be administered with caution”; “In vitro metabolism studies have indicated that cytochrome P450 1A2 (CYP1A2) is the major enzyme responsible for the metabolism of rasagiline. C ...
Review of Pharmacological Effects of Glycyrrhiza sp. and its
... β-glycyhrritinic acid is a potent inhibitor of 11βhydroxysteroid hydroxygenase (Walker and Edwards, 1991), it causes an accumulation of glucocorticoids with antiinflammatory properties. Oral administration of β-glycyhrritinic acid or glycyrrhizin confirmed this result (MacKenzie et al., 1990). Second, ...
... β-glycyhrritinic acid is a potent inhibitor of 11βhydroxysteroid hydroxygenase (Walker and Edwards, 1991), it causes an accumulation of glucocorticoids with antiinflammatory properties. Oral administration of β-glycyhrritinic acid or glycyrrhizin confirmed this result (MacKenzie et al., 1990). Second, ...
Sulfamethoxazole / Trimethoprim Sulfamethoxazole / Trimethoprim
... effects have occurred in up to 80% of AIDS patients receiving the drug but generally have been reversible following discontinuation of SMX-TMP therapy. Glutathione deficiency in HIV infected patients and the resultant accumulation of reactive hydroxylamine metabolites of sulfamethoxazole may be invo ...
... effects have occurred in up to 80% of AIDS patients receiving the drug but generally have been reversible following discontinuation of SMX-TMP therapy. Glutathione deficiency in HIV infected patients and the resultant accumulation of reactive hydroxylamine metabolites of sulfamethoxazole may be invo ...
Journal of Central Nervous System Disease Pharmacological
... adolescents,37 and improved brain dysfunction as previously mentioned. Due to abuse and addiction potential of stimulants, the first-line pharmacological agents for ADHD, many caregivers are reluctant to consider such treatment for their child or adolescent. However it is important to note that most ...
... adolescents,37 and improved brain dysfunction as previously mentioned. Due to abuse and addiction potential of stimulants, the first-line pharmacological agents for ADHD, many caregivers are reluctant to consider such treatment for their child or adolescent. However it is important to note that most ...
SERC PM
... The safety and efficacy of SERC® in pediatric patients below 18 years of age have not been evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient ...
... The safety and efficacy of SERC® in pediatric patients below 18 years of age have not been evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient ...
product monograph serc
... The safety and efficacy of SERC® in pediatric patients below 18 years of age have not been evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient ...
... The safety and efficacy of SERC® in pediatric patients below 18 years of age have not been evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient ...
hydromorphone hydrochloride ciir
... Central Nervous System: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes. Gastrointestinal System: Nausea, and vomiting occur infrequently; they are more frequent in ambulatory than i ...
... Central Nervous System: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes. Gastrointestinal System: Nausea, and vomiting occur infrequently; they are more frequent in ambulatory than i ...
How should I prescribe methadone for detoxification
... and an initial dose was agreed upon. This dose was then gradually decreased over ten days in a flexible dosing schedule, with concurrent toxicological urinalysis to ensure no illicit drug use. During the trial, 25% of patients transferred to a maintenance programme and 58% remained in the study. The ...
... and an initial dose was agreed upon. This dose was then gradually decreased over ten days in a flexible dosing schedule, with concurrent toxicological urinalysis to ensure no illicit drug use. During the trial, 25% of patients transferred to a maintenance programme and 58% remained in the study. The ...
GPCR ontology: development and application of a G protein
... (Sharman et al., 2011), GPCR Oligomerization Knowledge Base (GPCR-OKB, computational and experimental information on GPCR oligomerization) (Khelashvili et al., 2010) and GPCRDB (collection of GPCR sequences, ligand binding constants and mutations) (Horn et al., 2003), among others. Although the scie ...
... (Sharman et al., 2011), GPCR Oligomerization Knowledge Base (GPCR-OKB, computational and experimental information on GPCR oligomerization) (Khelashvili et al., 2010) and GPCRDB (collection of GPCR sequences, ligand binding constants and mutations) (Horn et al., 2003), among others. Although the scie ...
Headache
... Excessive consumption of Aspartic Acid can cause Headaches (by causing over-stimulation of the Nmethyl-D-aspartate (NMDA) Receptors in the Brain. Excessive consumption of Glutamic Acid can cause Headaches (by causing over-stimulation of the Nmethyl-D-aspartate (NMDA) Receptors in the Brain. Monosodi ...
... Excessive consumption of Aspartic Acid can cause Headaches (by causing over-stimulation of the Nmethyl-D-aspartate (NMDA) Receptors in the Brain. Excessive consumption of Glutamic Acid can cause Headaches (by causing over-stimulation of the Nmethyl-D-aspartate (NMDA) Receptors in the Brain. Monosodi ...
MSM (Methylsulfonylmethane)
... Although the Arthritis Foundation reports that MSM is used for pain and inflammation, they do not recommend its use due to lack of clinical trials. Brief Safety Summary: Likely Safe: Studies have shown safety and tolerability of MSM products when used orally in recommended doses (1). Note: No studi ...
... Although the Arthritis Foundation reports that MSM is used for pain and inflammation, they do not recommend its use due to lack of clinical trials. Brief Safety Summary: Likely Safe: Studies have shown safety and tolerability of MSM products when used orally in recommended doses (1). Note: No studi ...
Pharmacokinetic and pharmacodynamic drug interactions
... J. Anke, I. Ramzan / Journal of Ethnopharmacology 93 (2004) 153–160 ...
... J. Anke, I. Ramzan / Journal of Ethnopharmacology 93 (2004) 153–160 ...
Pulmonary Drug Absorption
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
Hydromorphone Hydrochloride Injection, USP, CII (1 mg/mL)
... occurs most frequently in the elderly, in the debilitated, and in those suffering from conditions accompanied by hypoxia or hypercapnia, or upper airway obstruction in whom even moderate therapeutic doses may dangerously decrease pulmonary ventilation. Respiratory depression is also a particular pro ...
... occurs most frequently in the elderly, in the debilitated, and in those suffering from conditions accompanied by hypoxia or hypercapnia, or upper airway obstruction in whom even moderate therapeutic doses may dangerously decrease pulmonary ventilation. Respiratory depression is also a particular pro ...
the full case study
... both quinidine and verapamil inhibit the secretion of digoxin by p-glycoprotein transporters in the kidney leading to decreased renal tubular elimination of digoxin and increased serum concentrations.[6114] It has been recommended that digoxin doses be reduced by 50% when adding quinidine therapy, a ...
... both quinidine and verapamil inhibit the secretion of digoxin by p-glycoprotein transporters in the kidney leading to decreased renal tubular elimination of digoxin and increased serum concentrations.[6114] It has been recommended that digoxin doses be reduced by 50% when adding quinidine therapy, a ...
Lipid Nanoparticulate Drug Delivery Systems: A
... their size-dependent properties. Among the array of nanoparticles being currently investigated by pharmaceutical scientists, lipid nanoparticles have taken the lead because of obvious advantages of higher degree of biocompatibility and versatility. These systems are commercially viable to formulate ...
... their size-dependent properties. Among the array of nanoparticles being currently investigated by pharmaceutical scientists, lipid nanoparticles have taken the lead because of obvious advantages of higher degree of biocompatibility and versatility. These systems are commercially viable to formulate ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.