Retrospective Review of Trend in Modafinil Overexposures
... rising trend in the use and abuse of medications like modafinil. However, our study evaluated the trend in modafinil ingestion over a ten-year period and found only 4% of all reported exposures to be due to abuse. A peak in modafinil ingestions was observed prior to 2008. Certain events related to t ...
... rising trend in the use and abuse of medications like modafinil. However, our study evaluated the trend in modafinil ingestion over a ten-year period and found only 4% of all reported exposures to be due to abuse. A peak in modafinil ingestions was observed prior to 2008. Certain events related to t ...
Clinical and pharmacological evaluation of buprenorphine and
... route, it would have the opposite effects, precipitating substantial opiate withdrawal. This was an unusual requirement for a new drug formulation. In general, successful medications do not produce unpleasant effects and exhibit minimal interindividual variability. However, the buprenorphine and nal ...
... route, it would have the opposite effects, precipitating substantial opiate withdrawal. This was an unusual requirement for a new drug formulation. In general, successful medications do not produce unpleasant effects and exhibit minimal interindividual variability. However, the buprenorphine and nal ...
Target Regimen Profiles for TB Treatment
... There is an urgent need for safer, simpler, more efficacious and accessible treatment regimens for all forms of TB. The development of target product profiles for TB drug regimens (hereafter referred as target regimen profiles) is meant to assist drug regimen developers in identifying important regi ...
... There is an urgent need for safer, simpler, more efficacious and accessible treatment regimens for all forms of TB. The development of target product profiles for TB drug regimens (hereafter referred as target regimen profiles) is meant to assist drug regimen developers in identifying important regi ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... WARNING: LACTIC ACIDOSIS/SEVERE HEPATOMEGALY WITH STEATOSIS and POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs in combination with other antiretrovirals [see Warning ...
... WARNING: LACTIC ACIDOSIS/SEVERE HEPATOMEGALY WITH STEATOSIS and POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs in combination with other antiretrovirals [see Warning ...
Propoxyphene Napsylate and Acetaminophen Tablets
... information regarding the treatment of overdosage may change more rapidly than do package inserts. Initial consideration should be given to the management of the CNS effects of propoxyphene overdosage. Resuscitative measures should be initiated promptly. Symptoms of Propoxyphene Overdosage The manif ...
... information regarding the treatment of overdosage may change more rapidly than do package inserts. Initial consideration should be given to the management of the CNS effects of propoxyphene overdosage. Resuscitative measures should be initiated promptly. Symptoms of Propoxyphene Overdosage The manif ...
Annex 1 - Emcdda
... the Early Warning System. These include: 25B-NBOMe, 25C-NBOMe, 25H-NBOMe, 25ENBOMe, 25N-NBOMe, 25D-NBOMe, 25iP-NBOMe, 25G-NBOMe, 25B-N(BOMe)2, 25INBMD, C30-NBOMe, and RH-34. There appear to be no co-ordinated national or European population surveys on the prevalence of 25I-NBOMe use. There are repor ...
... the Early Warning System. These include: 25B-NBOMe, 25C-NBOMe, 25H-NBOMe, 25ENBOMe, 25N-NBOMe, 25D-NBOMe, 25iP-NBOMe, 25G-NBOMe, 25B-N(BOMe)2, 25INBMD, C30-NBOMe, and RH-34. There appear to be no co-ordinated national or European population surveys on the prevalence of 25I-NBOMe use. There are repor ...
Reviews Essential Tremor - Tremor and Other Hyperkinetic
... transmission of other neurotransmitters, usually glutamate, and they are thus usually inhibitory. The mechanism is quite distinct from ‘‘calcium channel blockers’’. Levetiracetam may improve tremor.59,60 It is proposed to have a unique MOA, inhibition of the synaptic vesicle protein 2A (SV2A).61 The ...
... transmission of other neurotransmitters, usually glutamate, and they are thus usually inhibitory. The mechanism is quite distinct from ‘‘calcium channel blockers’’. Levetiracetam may improve tremor.59,60 It is proposed to have a unique MOA, inhibition of the synaptic vesicle protein 2A (SV2A).61 The ...
PRODUCT MONOGRAPH PrDEPO-MEDROL* WITH LIDOCAINE
... Literature reports suggest an apparent association between the use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients. As sodium retention with resultant edema and ...
... Literature reports suggest an apparent association between the use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients. As sodium retention with resultant edema and ...
NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)
... cytoprotective role inhibiting the proton pump and thereby decreasing gastric acid synthesis, stimulating the production of glutathione that scavenges superoxides, promoting the generation of a protective barrier of mucous and bicarbonate, and promoting adequate blood flow to the gastric muscosal ce ...
... cytoprotective role inhibiting the proton pump and thereby decreasing gastric acid synthesis, stimulating the production of glutathione that scavenges superoxides, promoting the generation of a protective barrier of mucous and bicarbonate, and promoting adequate blood flow to the gastric muscosal ce ...
WELLBUTRIN® (bupropion hydrochloride) Tablets
... number was not sufficient to reach any conclusion about drug effect on suicide. It is unknown whether the suicidality risk extends to longer-term use, i.e., beyond several months. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use ...
... number was not sufficient to reach any conclusion about drug effect on suicide. It is unknown whether the suicidality risk extends to longer-term use, i.e., beyond several months. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use ...
Valproate Learning Objectives Outline Indications
... documented cases from only Germany over 10 years corroborates that the occurrence of this severe side effect is under reported.” ...
... documented cases from only Germany over 10 years corroborates that the occurrence of this severe side effect is under reported.” ...
http://www.utdallas.edu/~tres/papers/moyer.etal.92.pdf
... glass omegadot microelectrodes filled with 3 M KC1 (20-80 MQ) were used for recording. Bipolar tungsten stimulating electrodes were placed in the alveus (or fimbria/fornix) and Schaffer collaterals under visual guidance. A CA 1 neuron was classified as a pyramidal cell if it exhibited accommodation ...
... glass omegadot microelectrodes filled with 3 M KC1 (20-80 MQ) were used for recording. Bipolar tungsten stimulating electrodes were placed in the alveus (or fimbria/fornix) and Schaffer collaterals under visual guidance. A CA 1 neuron was classified as a pyramidal cell if it exhibited accommodation ...
Synthetic cannabinoids in herbal products
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
ACTELION`S NEW DUAL OREXIN RECEPTOR ANTAGONIST
... MINIMAL BURDEN ON THE PATIENT Clinical studies in children are associated with specific requirements ...
... MINIMAL BURDEN ON THE PATIENT Clinical studies in children are associated with specific requirements ...
Bioisosterism: A Rational Approach in Drug Design
... a Concentration of compound that decreased specific binding of 1.5 nM [3H]diazepam to rat brain receptors by 50%. ...
... a Concentration of compound that decreased specific binding of 1.5 nM [3H]diazepam to rat brain receptors by 50%. ...
The increasing recreational use of nitrous oxide: history revisited
... depth of respiration, and breath-holding to alter washout of nitrogen, oxygen, and carbon dioxide from the lungs. Such hypoxaemia should be well tolerated by a fit person but could give rise to seizures, arrhythmias, or even respiratory or cardiac arrest in patients with epilepsy, cardiac disease, or ...
... depth of respiration, and breath-holding to alter washout of nitrogen, oxygen, and carbon dioxide from the lungs. Such hypoxaemia should be well tolerated by a fit person but could give rise to seizures, arrhythmias, or even respiratory or cardiac arrest in patients with epilepsy, cardiac disease, or ...
wet granulation
... the die wall during the tablet’s ejection from the tablet machine. • 4. Lubricants give a sheen to the finished tablets. ...
... the die wall during the tablet’s ejection from the tablet machine. • 4. Lubricants give a sheen to the finished tablets. ...
Hypericum perforatum Monograph
... in the eight-week trial, researchers failed to demonstrate any significant differences in HAMD or Beck Depression Inventory scores between the drug and St. John’s wort groups at the end of 12 weeks. As noted in other studies comparing St. John’s wort to antidepressant drugs, fewer side effects were ...
... in the eight-week trial, researchers failed to demonstrate any significant differences in HAMD or Beck Depression Inventory scores between the drug and St. John’s wort groups at the end of 12 weeks. As noted in other studies comparing St. John’s wort to antidepressant drugs, fewer side effects were ...
An Introduction to Medicinal Chemistry
... to expect all painkillers to look alike or to have some common thread running through them is not realistic. A further point is that many drugs do not fit purely into one category or another and some drugs may have more uses than just one. For example, a sedative might also have uses as an anticonvu ...
... to expect all painkillers to look alike or to have some common thread running through them is not realistic. A further point is that many drugs do not fit purely into one category or another and some drugs may have more uses than just one. For example, a sedative might also have uses as an anticonvu ...
Pharmacology and the Nursing Process, 4th ed. Lilley
... can modify the rate (increase or decrease) at which the cells or tissues function • A drug cannot make a cell or tissue perform a function it was not designed to perform Mosby items and derived items © 2005, 2002 by Mosby, Inc. ...
... can modify the rate (increase or decrease) at which the cells or tissues function • A drug cannot make a cell or tissue perform a function it was not designed to perform Mosby items and derived items © 2005, 2002 by Mosby, Inc. ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... Amphetamines have a high potential for abuse. Administration of amphetamines for prolonged periods of time may lead to drug dependence. Pay particular attention to the possibility of subjects obtaining amphetamines for nontherapeutic use or distribution to others and the drugs should be prescribed o ...
... Amphetamines have a high potential for abuse. Administration of amphetamines for prolonged periods of time may lead to drug dependence. Pay particular attention to the possibility of subjects obtaining amphetamines for nontherapeutic use or distribution to others and the drugs should be prescribed o ...
09107sgp04
... some adverse effects on human, a similar study was taken on human. The result had shown that no clinically relevant serious adverse cardiac effects have been observed in studies in man. Co-administration did not modify other class-related toxicities in animals. Besides, The use of inhaled salmeterol ...
... some adverse effects on human, a similar study was taken on human. The result had shown that no clinically relevant serious adverse cardiac effects have been observed in studies in man. Co-administration did not modify other class-related toxicities in animals. Besides, The use of inhaled salmeterol ...
Hormesis: Once Marginalized, Evidence Now Supports Hormesis as
... performed, the general focus of mechanistic research, drug efficacy and safety evaluation, and governmental environmental risk assessment practices for protecting humans and other life against threats to food, water, air, and soil. The dose-response relationship is also a fundamental concept of biol ...
... performed, the general focus of mechanistic research, drug efficacy and safety evaluation, and governmental environmental risk assessment practices for protecting humans and other life against threats to food, water, air, and soil. The dose-response relationship is also a fundamental concept of biol ...
Nicotine
... • There is increased risk of heart diseases in the long-term due to nicotine addiction. Nicotine causes narrowing down of the blood canals. It is because nicotine gets attached to its receptor proteins in the blood vessel and stays there and thus causes constriction of blood canals. • Also, in the l ...
... • There is increased risk of heart diseases in the long-term due to nicotine addiction. Nicotine causes narrowing down of the blood canals. It is because nicotine gets attached to its receptor proteins in the blood vessel and stays there and thus causes constriction of blood canals. • Also, in the l ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.