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Common errors in multidrug-resistant tuberculosis management
Common errors in multidrug-resistant tuberculosis management

... patients in need [5]. As we have witnessed, even in countries that have new rapid tests in referral centers, access to MDR-TB diagnosis is difficult. There are several reasons including centralized use, weaknesses of health systems, lack of coordination, inefficient communication and other different ...
6 points each
6 points each

... 9. Dry mouth is a major side effect of olanzapine in many patients. Orthostatic hypotension is also seen in some patients. Theoretically, what kinds of change(s) in receptor binding would be desirable in a new drug (call it “neo-olanzapine”) that would have the same therapeutic effect and potency as ...
Diuretics
Diuretics

... From Beaumont et al.: Thiazide diuretic drug receptors in rat kidney: identification with [3H]metolazone. Proc. Natl. Acad. Sci. USA 1988, 85:2311-2314. ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

CDER SBIA and New Drug Review
CDER SBIA and New Drug Review

...  Represent the Agency’s current thinking on a particular subject  Provide flexibility as technology and drug development processes evolve ...
Updates Neuropathic Pain
Updates Neuropathic Pain

... of L-type calcium channels and directly block the pore CCBs prevent movement of Ca2+ CCBs work in the peripheral vascular smooth muscle and relax arteries to reduce systemic blood pressure ...
PLASMA FRACTIONS (cont`d)
PLASMA FRACTIONS (cont`d)

Regulating Drug Prices with Ramsey Pricing Principles
Regulating Drug Prices with Ramsey Pricing Principles

... • How do we make pair wise ICERs give us an unambiguous answer when there are more than two drugs in the therapeuitc area? ...
In the year after going tobacco free
In the year after going tobacco free

... Comparison of all patients treated in the six months before going tobacco free and the year after going tobacco free. In the six months before – patients allowed to go outside to smoke. After going tobacco free patients were expected to completely refrain from tobacco use during treatment. All patie ...
View/Open - Victoria University of Wellington
View/Open - Victoria University of Wellington

... causation. However, recent re-examination of clinical trials has raised questions regarding antidepressant drug efficacy, and issues around side effects and dependency are prevalent. In spite of this, as many as 10% of us may be taking these medications (Szabo, 2009). This study examines responses t ...
9 Eating disorders and substance use
9 Eating disorders and substance use

... Fluvoxamine, fluoxetine, norfluoxetine and paroxetine can inhibit buprenorphine and methadone metabolism through inhibition of the CYPs involved in their metabolism(148-150). This can result in an increase in plasma opioid pharmacotherapy concentrations and potential overdose. This can be a ...
High Performance Liquid Chromatography for Clinical Applications
High Performance Liquid Chromatography for Clinical Applications

... reliability,  versatility  and  generally  low  cost  of  operation.     TLC  is  a  very  simple  method  easy  to  implement  that  was  first  developed  in  the  1940s.  It  is  used  today  in   the  clinical  laboratory  mostly ...
Version 1
Version 1

... Withdrawal symptoms may include yawning, mydriasis, lacrimation, rhinorrhoea, tremor, hyperhidrosis, anxiety, agitation, convulsions and insomnia. ...
Print - Philosophical Transactions of the Royal Society B
Print - Philosophical Transactions of the Royal Society B

... important aspect of interactions between humans and the natural environment. In the process of understanding and treating diseases, man has discovered by trial and error a variety of natural products, mostly from plant sources, of therapeutic value. Many of these medicinal plants contain several act ...
Current trends in the development of antiviral drugs
Current trends in the development of antiviral drugs

... 3. OVERWIEW OF OLDER ANTIVIRAL DRUGS Since 1960’s many antiviral drugs have been discovered and gave us the opportunity to deal with many viral infections that we could not before. Most of them are efficiently used nowadays, while new substances are tested in order to produce new, safer and more ef ...
News Release
News Release

... United   States,   including   Protonix   Oral   and   intravenous   Protonix   IV.     Protonix   Oral   and   Protonix   IV   are   in   a   class   of   drugs   called   proton   pump   inhibitors   which   inhibit   the   production  of ...
Might stimulant drugs support moral agency in ADHD children? Steven Edward Hyman
Might stimulant drugs support moral agency in ADHD children? Steven Edward Hyman

... effects of stimulants are transient. Only when individuals take the very high doses that characterise drug abuse, and do so for extended periods of time, do persistent negative effects emerge, including addiction and psychotic symptoms. In the therapeutic dose range, even long-acting formulations of ...
- ISpatula
- ISpatula

... b. Acute adrenocortical insufficiency (adrenal crisis) • Life-threatening disease characterized by GI symptoms (nausea, vomiting, and abdominal pain), dehydration, hyponatremia, hyperkalemia, weakness, lethargy, and hypotension • The most common cause is abrupt withdrawal of exogenous glucocorticoid ...
as a PDF
as a PDF

... has unique memory and cognitive enhancing properties that might be useful in the treatment of neurological disorders at doses that do not produce adverse effects such as salivation. ...
steroids - Wikispaces
steroids - Wikispaces

... skeletal muscle in laboratory animals. This led to abuse of these compounds by bodybuilders and weightlifters and then by athletes in other sports ...
Exposure to benzylpiperazine (BZP) in adolescent rats: Adulthood
Exposure to benzylpiperazine (BZP) in adolescent rats: Adulthood

Substance use disorders: treatment with genetic potential?
Substance use disorders: treatment with genetic potential?

... (b) Difficulty in controlling substance use, such as: onset, termination, or quantity; (c) Withdrawal symptoms based on the type of drug used, including the use of the same/similar substance to relieve/circumvent withdrawal symptoms; (d) Tolerance, such that increased doses are required to achieve t ...
Cocaine-Induced Craving
Cocaine-Induced Craving

... –Significantly more neurotoxicity than cocaine ...


... three disparate benzodiazepine use patterns. These distinct benzodiazepine use patterns can in turn create distinct withdrawal syndromes. High-dose benzodiazepine use between 1 and 6 months can produce an acute sedative-hypnotic withdrawal syndrome. In contrast, low-dose therapeutic range benzodiaze ...
Treadmill training after spinal cord injury
Treadmill training after spinal cord injury

... rehabilitation options. This sobering result reaffirms the critical importance of well-controlled properly blinded studies, particularly for resolving issues involving prolonged interventions for complex long-term disorders. At the same time that it lowers the expectations for BWSTT, the study provi ...
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Psychopharmacology



Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.
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