GSTP1 cocaine dependence
... and smoking have concentrated on the variable number of tandem repeats (VNTRs) polymorphism in the 30 untranslated region of the gene (30 UTR) [13–15]. The initial two studies used retrospective self-reports of smoking status as the target phenotype. Lerman et al. [16] found that people with a varia ...
... and smoking have concentrated on the variable number of tandem repeats (VNTRs) polymorphism in the 30 untranslated region of the gene (30 UTR) [13–15]. The initial two studies used retrospective self-reports of smoking status as the target phenotype. Lerman et al. [16] found that people with a varia ...
Document
... Flurorquinolones (FQs) are a class of important synthetic antibiotics, which are active against both Gram (+) and Gram (-) bacteria through inhibition of their DNA gyrase [1]. Their excellent pharmacokinetic profile, good tissular penetration and wide scope of activity have made these drugs very use ...
... Flurorquinolones (FQs) are a class of important synthetic antibiotics, which are active against both Gram (+) and Gram (-) bacteria through inhibition of their DNA gyrase [1]. Their excellent pharmacokinetic profile, good tissular penetration and wide scope of activity have made these drugs very use ...
Heroin and cocaine co-use in a group of injection drug users in
... It is important to study the incidence and patterns of polydrug use, because a large proportion of drug users regularly consume more than one substance. The concomitant use of opioid drugs and cocaine is one type of polydrug use that has been documented in diverse subgroups of the drug-using populat ...
... It is important to study the incidence and patterns of polydrug use, because a large proportion of drug users regularly consume more than one substance. The concomitant use of opioid drugs and cocaine is one type of polydrug use that has been documented in diverse subgroups of the drug-using populat ...
Volume 48 Number 4
... in Pharmacological Reviews, the Abel number, and other surprises. Public Affairs: ASPET continues its leading advocacy to increase training for integrative organ systems pharmacology. ASPET is also committed to making significant contributions through its new affiliation with The FDA Alliance to inc ...
... in Pharmacological Reviews, the Abel number, and other surprises. Public Affairs: ASPET continues its leading advocacy to increase training for integrative organ systems pharmacology. ASPET is also committed to making significant contributions through its new affiliation with The FDA Alliance to inc ...
PDF hosted at the Radboud Repository of the Radboud University
... patient’s condition? Is each dosage correct? Are the directions for use correct and practical? Are there any clinically significant drug-drug interactions or drug-disease interactions? Is there any unnecessary duplication with another drug? Is the duration of therapy acceptable? Is each medication t ...
... patient’s condition? Is each dosage correct? Are the directions for use correct and practical? Are there any clinically significant drug-drug interactions or drug-disease interactions? Is there any unnecessary duplication with another drug? Is the duration of therapy acceptable? Is each medication t ...
oral controlled release drug delivery system
... pH change in the gastrointestinal tract. The addition of surfactants to the formulation can also influence both the drug release rate and the proportion of total drug that can be incorporated into a matrix. Dissolution Controlled Systems A drug with a slow dissolution rate is inherently sustained an ...
... pH change in the gastrointestinal tract. The addition of surfactants to the formulation can also influence both the drug release rate and the proportion of total drug that can be incorporated into a matrix. Dissolution Controlled Systems A drug with a slow dissolution rate is inherently sustained an ...
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine
... intraperitoneal administration of MFZ 10-7 inhibited intravenous cocaine self-administration, cocaine-induced reinstatement of drug-seeking behavior and cocaine-associated cue-induced cocaine-seeking behavior in rats. Although MFZ 10-7 and MTEP lowered the rate of oral sucrose self-administration, t ...
... intraperitoneal administration of MFZ 10-7 inhibited intravenous cocaine self-administration, cocaine-induced reinstatement of drug-seeking behavior and cocaine-associated cue-induced cocaine-seeking behavior in rats. Although MFZ 10-7 and MTEP lowered the rate of oral sucrose self-administration, t ...
Pain Management in Older Adults www.rxfiles.ca
... • Exercise/activity as tolerated, physiotherapy, weight loss may be beneficial for those with arthritis & musculoskeletal pain. (May include activity like Tai Chi.) • Massage, acupuncture & bathing may be helpful. • Psychological interventions such as counselling & cognitive behavioural therapy ...
... • Exercise/activity as tolerated, physiotherapy, weight loss may be beneficial for those with arthritis & musculoskeletal pain. (May include activity like Tai Chi.) • Massage, acupuncture & bathing may be helpful. • Psychological interventions such as counselling & cognitive behavioural therapy ...
This Guidance updates a Faculty ... Professional Development Topic (FACT) on ...
... the levonorgestrel-releasing intrauterine system (LNGIUS)] is reduced by liver enzyme-inducing drugs. Non-liver enzyme-inducing antibiotics are used relatively frequently. The enterohepatic circulation of EE may be reduced and therefore the efficacy of combined contraception may be reduced. Evidence ...
... the levonorgestrel-releasing intrauterine system (LNGIUS)] is reduced by liver enzyme-inducing drugs. Non-liver enzyme-inducing antibiotics are used relatively frequently. The enterohepatic circulation of EE may be reduced and therefore the efficacy of combined contraception may be reduced. Evidence ...
A. Thyroids Hormones
... localized in rourg ER, Golgi vesicle & follicular cell surface • Thyroid antimicrosomal antibodies found in patients with autoimmune thyroid disease are directed against the TPO enzyme • Thyroid-stimulating hormone (TSH) : regulates thyroidal iodine metabolism by activation of adenylate cyclase --> ...
... localized in rourg ER, Golgi vesicle & follicular cell surface • Thyroid antimicrosomal antibodies found in patients with autoimmune thyroid disease are directed against the TPO enzyme • Thyroid-stimulating hormone (TSH) : regulates thyroidal iodine metabolism by activation of adenylate cyclase --> ...
Advice to The Expert Advisory Committee on drugs on: LSD
... fragmentary recurrence of a previous LSD experience, and may occur weeks, months, or years after the last usage. These are generally not considered to be troubling or impairing. Less commonly people experience hallucinogen persisting perception disorder (HPPD) when the perceptual effects reminiscent ...
... fragmentary recurrence of a previous LSD experience, and may occur weeks, months, or years after the last usage. These are generally not considered to be troubling or impairing. Less commonly people experience hallucinogen persisting perception disorder (HPPD) when the perceptual effects reminiscent ...
Epidural Analgesia in the Dog and Cat
... horn. They are throught to work on pre-synaptic sites by preventing the release of substance P and on post-synaptic receptors to hyperpolarize the cells. Hence, they obtund nociception without any significant effect on motor function. The potency of the different opioids, when they are administered ...
... horn. They are throught to work on pre-synaptic sites by preventing the release of substance P and on post-synaptic receptors to hyperpolarize the cells. Hence, they obtund nociception without any significant effect on motor function. The potency of the different opioids, when they are administered ...
Organised Crime and Drugs in Sport
... In recent years, peptides have become increasingly popular among professional and amateur athletes, bodybuilders, and as a ‘fountain of youth’ within the anti-ageing fraternity. Growth hormone releasing peptides stimulate release of an increased level of human growth hormone (hGH), which has a histo ...
... In recent years, peptides have become increasingly popular among professional and amateur athletes, bodybuilders, and as a ‘fountain of youth’ within the anti-ageing fraternity. Growth hormone releasing peptides stimulate release of an increased level of human growth hormone (hGH), which has a histo ...
L11&12-Final drugs in hyperlipidem2014-08
... only hypertriglyceridemia & low HDL without in LDL Why ??? because these patients will possess small dense LDL (severely atherogenic) + evident endothelial dysfunction + increased thrombotic profile. ...
... only hypertriglyceridemia & low HDL without in LDL Why ??? because these patients will possess small dense LDL (severely atherogenic) + evident endothelial dysfunction + increased thrombotic profile. ...
Clinical pharmacology of anti-infectives and nonsteroidal_англ
... 20. Which of the following agents used in the treatment of pulmonary tuberculosis has a toxicity of producing a lupus-like syndrome? A. *isoniazid B. rifampin C. ethambutol D. streptomycin E. para-amino salicylic acid 21. Isoniazid-induced liver damage: A. occurs primarily in patients under 30 years ...
... 20. Which of the following agents used in the treatment of pulmonary tuberculosis has a toxicity of producing a lupus-like syndrome? A. *isoniazid B. rifampin C. ethambutol D. streptomycin E. para-amino salicylic acid 21. Isoniazid-induced liver damage: A. occurs primarily in patients under 30 years ...
opioids 2006 - addiction education home
... The opioid receptors, mu, delta and kappa, conduct the major pharmacological effects of opioid drugs, and exhibit intriguing functional relationships and interactions in the CNS. Previously established hypotheses regarding the mechanisms underlying these phenomena specify theoretical patterns of rel ...
... The opioid receptors, mu, delta and kappa, conduct the major pharmacological effects of opioid drugs, and exhibit intriguing functional relationships and interactions in the CNS. Previously established hypotheses regarding the mechanisms underlying these phenomena specify theoretical patterns of rel ...
Asia - INCB
... abuse patterns. Drug law enforcement authorities have been successful in seizing significant quantities of illicitly manufactured drugs entering or passing through Chile. 372. Chile is an important manufacturer and importer of precursor chemicals. Some of those precursor chemicals have been diverted ...
... abuse patterns. Drug law enforcement authorities have been successful in seizing significant quantities of illicitly manufactured drugs entering or passing through Chile. 372. Chile is an important manufacturer and importer of precursor chemicals. Some of those precursor chemicals have been diverted ...
pharmacy technician certification examination content outline......
... It is very important for technicians to know when to answer a patient’s question and when to refer the patient to the pharmacist. Technicians SHOULD NOT interpret a patient-specific question or provide information that may require professional judgment. The technician is not the one to tell the pati ...
... It is very important for technicians to know when to answer a patient’s question and when to refer the patient to the pharmacist. Technicians SHOULD NOT interpret a patient-specific question or provide information that may require professional judgment. The technician is not the one to tell the pati ...
Case Report[ Fatal Cold Medication Intoxication in an Infant
... The qualitative screening procedure that disclosed the presence of pseudoephedrine, brompheniramine, and dextromethorphan was a general drug screen for chemically basic drugs adapted from Pierce et al. (2). Briefly, 1 mL of saturated sodium borate buffer (pH 9) and 1 mL of cyclizine internal standar ...
... The qualitative screening procedure that disclosed the presence of pseudoephedrine, brompheniramine, and dextromethorphan was a general drug screen for chemically basic drugs adapted from Pierce et al. (2). Briefly, 1 mL of saturated sodium borate buffer (pH 9) and 1 mL of cyclizine internal standar ...
Azoles and Barbiturates
... also block the AMPA receptor which is sensitive to glutamate, the excitatory neurotransmitter. Glutamate performs the opposite effect from GABA restricting ion flow and increasing the transmembrane action potential of the neuron. By blocking this action Barbiturates serve to increase the duration of ...
... also block the AMPA receptor which is sensitive to glutamate, the excitatory neurotransmitter. Glutamate performs the opposite effect from GABA restricting ion flow and increasing the transmembrane action potential of the neuron. By blocking this action Barbiturates serve to increase the duration of ...
Tegretol Tegretol -XR WARNINGS
... In clinical studies, Tegretol suspension, conventional tablets, and XR tablets delivered equivalent amounts of drug to the systemic circulation. However, the suspension was absorbed somewhat faster, and the XR tablet slightly slower, than the conventional tablet. The bioavailability of the XR tablet ...
... In clinical studies, Tegretol suspension, conventional tablets, and XR tablets delivered equivalent amounts of drug to the systemic circulation. However, the suspension was absorbed somewhat faster, and the XR tablet slightly slower, than the conventional tablet. The bioavailability of the XR tablet ...
Dostinex - Centre for Medicines Optimisation
... menstrual disorders, and galactorrhoea. In men, symptoms generally include reduced libido and/or impotence. Hypogonadism caused by hyperprolactinaemia can lead to infertility, but also to conditions such as osteoporosis due to low oestrogen levels. Hyperprolactinaemia can be idiopathic, or caused by ...
... menstrual disorders, and galactorrhoea. In men, symptoms generally include reduced libido and/or impotence. Hypogonadism caused by hyperprolactinaemia can lead to infertility, but also to conditions such as osteoporosis due to low oestrogen levels. Hyperprolactinaemia can be idiopathic, or caused by ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.