Brain changes and drug addiction
... Cocaine and methamphetamine are strong reinforcers and highly addictive (tolerance and dependence) Following oral use, the effects of usually start within 30 minutes and last for many hours. Later, users may feel irritable, restless, anxious, depressed and lethargic. Upon chronic use: deficits in me ...
... Cocaine and methamphetamine are strong reinforcers and highly addictive (tolerance and dependence) Following oral use, the effects of usually start within 30 minutes and last for many hours. Later, users may feel irritable, restless, anxious, depressed and lethargic. Upon chronic use: deficits in me ...
Opioids
... o Long-Acting SR Beads: to be swallowed; if chewed or combined with alcohol, can cause release of too much morphine o Morphine SR + Naltrexone (Embeda): for continual use with decreased risk of abuse (if crushed, opioid antagonist naltrexone will be freed) o Post-Surgical Formulations (DepoDur): sin ...
... o Long-Acting SR Beads: to be swallowed; if chewed or combined with alcohol, can cause release of too much morphine o Morphine SR + Naltrexone (Embeda): for continual use with decreased risk of abuse (if crushed, opioid antagonist naltrexone will be freed) o Post-Surgical Formulations (DepoDur): sin ...
Untitled
... Drugs acting on metabolic process, cell wall and specific enzymes Basic concepts of mechanism of drug action: Introduction to macromolecular targets, carbohydrates, proteins, lipids and nucleic acids as possible drug targets. Classification of drugs. Enzyme inhibition and its types. 1) Drugs acting ...
... Drugs acting on metabolic process, cell wall and specific enzymes Basic concepts of mechanism of drug action: Introduction to macromolecular targets, carbohydrates, proteins, lipids and nucleic acids as possible drug targets. Classification of drugs. Enzyme inhibition and its types. 1) Drugs acting ...
Lecture 2
... drug-receptor interaction • drugs can potentially alter rate of any bodily/brain function • drugs cannot impart entirely new functions to cells • drugs do not create effects, only modify ongoing ones • drugs can allow for effects outside of normal physiological ...
... drug-receptor interaction • drugs can potentially alter rate of any bodily/brain function • drugs cannot impart entirely new functions to cells • drugs do not create effects, only modify ongoing ones • drugs can allow for effects outside of normal physiological ...
MOTM SALVINORIN A MAGIC MINT
... Tidgewell, P. Kannan, K. G. Holden, B. Gilmour, H. Navarro, R. B. Rothman and T. E. Prisinzano, J. Nat. Prod., 2006, 69, 107-112 (syntheses and reactions) J. R. Scheerer, J. F. Lawrence, G. C. Wang and D. A. Evans, J. Am. Chem. Soc., 2007, 129, 8968-8969 (synthesis of Salvinorin A) Philip Sherwell, ...
... Tidgewell, P. Kannan, K. G. Holden, B. Gilmour, H. Navarro, R. B. Rothman and T. E. Prisinzano, J. Nat. Prod., 2006, 69, 107-112 (syntheses and reactions) J. R. Scheerer, J. F. Lawrence, G. C. Wang and D. A. Evans, J. Am. Chem. Soc., 2007, 129, 8968-8969 (synthesis of Salvinorin A) Philip Sherwell, ...
doc Behavioural_Neuroscience_Jan_16
... o The binding causes ion channels to open. o The ions pass through and causing a postsynaptic potential. o A direct antagonist (receptor blocker) can also occupy the binding site therefore preventing the opening of the ion channel. Mechanisms of Drug Action: Noncompetitive Binding: ...
... o The binding causes ion channels to open. o The ions pass through and causing a postsynaptic potential. o A direct antagonist (receptor blocker) can also occupy the binding site therefore preventing the opening of the ion channel. Mechanisms of Drug Action: Noncompetitive Binding: ...
Nicotine Addiction and Withdrawal
... Dealing with withdrawal may not be easy, but you should know that: • The symptoms you may experience in the first few days happen because your body is returning to normal. • Most nicotine from your smoking is flushed from your body after an average of 4 to 5 days. • For those who suffer from uncomfo ...
... Dealing with withdrawal may not be easy, but you should know that: • The symptoms you may experience in the first few days happen because your body is returning to normal. • Most nicotine from your smoking is flushed from your body after an average of 4 to 5 days. • For those who suffer from uncomfo ...
Pharmacokinetics-Pharmacodynamics
... transport them back to presynaptic neuron. – Many drugs block carrier proteins for a specific neurotransmitter (e.g., SSRIs). ...
... transport them back to presynaptic neuron. – Many drugs block carrier proteins for a specific neurotransmitter (e.g., SSRIs). ...
5-HT2a – receptor agonist
... hallucinations and irrational behavior, myosis) • MDMA-like chemical structure + weak inhibitor MAO • extremely long time before peak (4-7 hours), effects last for 24-72 hours ...
... hallucinations and irrational behavior, myosis) • MDMA-like chemical structure + weak inhibitor MAO • extremely long time before peak (4-7 hours), effects last for 24-72 hours ...
753_Module2_GITract
... Also like to see increase peristalsis….so once out of gut… need to get it moving along So that it gets to colon more quickly To keep stuff in the stomach…we get increased tone of the esophageal sphincter ...
... Also like to see increase peristalsis….so once out of gut… need to get it moving along So that it gets to colon more quickly To keep stuff in the stomach…we get increased tone of the esophageal sphincter ...
Ganglionic Blocking Drugs and Nicotine
... neuron and activates nicotinic and muscarinic receptors on the SIF cells (when present), leading to the release of a catecholamine, presumably dopamine. Dopamine subsequently activates a receptor on the postganglionic nerve. The insert depicts the temporal postganglionic action potential, consisting ...
... neuron and activates nicotinic and muscarinic receptors on the SIF cells (when present), leading to the release of a catecholamine, presumably dopamine. Dopamine subsequently activates a receptor on the postganglionic nerve. The insert depicts the temporal postganglionic action potential, consisting ...
Topic 7
... neurodegenerative diseases. It is believed their relationship to these disesases is due to their role in excitotoxicity. Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through the process of excitotoxicity. Excessive glutamate, or exogenous excitotoxins acting on ...
... neurodegenerative diseases. It is believed their relationship to these disesases is due to their role in excitotoxicity. Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through the process of excitotoxicity. Excessive glutamate, or exogenous excitotoxins acting on ...
ADRENERGIC SYSTEM - LEC.2 2008
... propranolol to block the cardiac B- effect ( cardiac arrhythmias ) and phentolamine or chlorpromazine to control the effect of peripheral circulation that will be prominent when B effect are abolished . labetalol ( alpha and beta block ) would be un alternative . 2- NOR- ADRENALINE : 1- it is one of ...
... propranolol to block the cardiac B- effect ( cardiac arrhythmias ) and phentolamine or chlorpromazine to control the effect of peripheral circulation that will be prominent when B effect are abolished . labetalol ( alpha and beta block ) would be un alternative . 2- NOR- ADRENALINE : 1- it is one of ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.