Biosteres and You
... If only acting as a H-bond acceptor, can make it a tertiary amine or heterocyclic Nitrogen (ie: pyridine, imidazole). If replaced by an RO-H the H-bond donor effect is kept, but no longer a basic residue to bind acidic (an example is GHB as a biostere for GABA, see next ...
... If only acting as a H-bond acceptor, can make it a tertiary amine or heterocyclic Nitrogen (ie: pyridine, imidazole). If replaced by an RO-H the H-bond donor effect is kept, but no longer a basic residue to bind acidic (an example is GHB as a biostere for GABA, see next ...
Drugs on Skeletal Muscle
... used in balanced anesthesia. Succinylcholine (suxamethonium), another neuromuscular blocking drug, acting as a depolarizing agent, has been in use at the same time as tubocurarine. Both drugs have marked limitations and there has been an ongoing search for alternatives, the most successful being pan ...
... used in balanced anesthesia. Succinylcholine (suxamethonium), another neuromuscular blocking drug, acting as a depolarizing agent, has been in use at the same time as tubocurarine. Both drugs have marked limitations and there has been an ongoing search for alternatives, the most successful being pan ...
Respiratory drugs-nursing
... Mechanism of Action Muscarinic antagonist competitively inhibit effect of acetylcholine at muscarinic receptors – hence block the contraction of air way smooth muscle and the increase in secretion of mucus that occurs in response to vagal activity e.g atropine sulfate Systemic adverse effects as a r ...
... Mechanism of Action Muscarinic antagonist competitively inhibit effect of acetylcholine at muscarinic receptors – hence block the contraction of air way smooth muscle and the increase in secretion of mucus that occurs in response to vagal activity e.g atropine sulfate Systemic adverse effects as a r ...
NV and antidiarrheal drugs
... Maintenance of fluid and electrolyte balance, particularly in children and in the elderly by compensating lost fluid by oral or parenteral rehydrating therapy. Furthermore, the addition of zinc tablets for more than 6 months, in addition to oral rehydration therapy, is considered to be the 1st line ...
... Maintenance of fluid and electrolyte balance, particularly in children and in the elderly by compensating lost fluid by oral or parenteral rehydrating therapy. Furthermore, the addition of zinc tablets for more than 6 months, in addition to oral rehydration therapy, is considered to be the 1st line ...
Steroids: Estrogen and Progestin
... • Estrogens exert their effects by interaction with receptors that are members of the super family of nuclear receptors • The two estrogen receptor (ER) genes are located on separate chromosomes: ESR1 encodes ER-alpha and ESR2 encodes ERbeta • Both ERs are estrogen-dependent nuclear transcription fa ...
... • Estrogens exert their effects by interaction with receptors that are members of the super family of nuclear receptors • The two estrogen receptor (ER) genes are located on separate chromosomes: ESR1 encodes ER-alpha and ESR2 encodes ERbeta • Both ERs are estrogen-dependent nuclear transcription fa ...
HYPERTENSIN PHL315
... since the vasodilatation causes sever transient drop in blood pressure. This reflex stimulation causes increased heart rate and contractility, and also rennin release (causes marked fluid retention and edema). • In order for hydralazine to be useful, it needs to be combined with a β blocker (to prev ...
... since the vasodilatation causes sever transient drop in blood pressure. This reflex stimulation causes increased heart rate and contractility, and also rennin release (causes marked fluid retention and edema). • In order for hydralazine to be useful, it needs to be combined with a β blocker (to prev ...
Kinetic models
... for a drug to any particular "state" of the receptor. Therefore, the value of EC50 cannot directly be related to a molecular step (for example, binding of a drug to an inactive receptor). Similarly, the steepness of the relationship (n) is not directly related to the number of drug molecules which m ...
... for a drug to any particular "state" of the receptor. Therefore, the value of EC50 cannot directly be related to a molecular step (for example, binding of a drug to an inactive receptor). Similarly, the steepness of the relationship (n) is not directly related to the number of drug molecules which m ...
Role of Biopathways- Drug Repositioning and Determining side
... • The truth is we know very little about how the major drugs we take work – most drugs bind to a variety of targets with varying affinity • We know even less about what side effects they might have • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringi ...
... • The truth is we know very little about how the major drugs we take work – most drugs bind to a variety of targets with varying affinity • We know even less about what side effects they might have • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringi ...
Suicidal Death by Nicotine Poisoning
... death due to the ingestion of nicotine might not be common due to the delayed absorption of nicotine by its emetic effects. Nicotine can be absorbed following inhalation, ingestion, or dermal contact and then rapidly absorbed through the skin, alveoli, or oropharyngeal mucosa, and the gastrointestin ...
... death due to the ingestion of nicotine might not be common due to the delayed absorption of nicotine by its emetic effects. Nicotine can be absorbed following inhalation, ingestion, or dermal contact and then rapidly absorbed through the skin, alveoli, or oropharyngeal mucosa, and the gastrointestin ...
NIDA for Teens Facts on Drugs- Tobacco Addiction
... gum, inhalers, and lozenges, replace nicotine and relieve the symptoms of withdrawal. It is important to know that nicotine replacement medicines can be safely used as a medication when taken properly. They have lower overall nicotine levels than tobacco and they have little abuse potential since th ...
... gum, inhalers, and lozenges, replace nicotine and relieve the symptoms of withdrawal. It is important to know that nicotine replacement medicines can be safely used as a medication when taken properly. They have lower overall nicotine levels than tobacco and they have little abuse potential since th ...
Acetycholine Article
... and learning. The prime example of this involvement is seen with scopolamine which is known to block muscarinic subtype of acetylcholine receptors. Those given scopolamine often have short-term memory loss and cannot recall events while they are under the influence of the drug. Other experiments hav ...
... and learning. The prime example of this involvement is seen with scopolamine which is known to block muscarinic subtype of acetylcholine receptors. Those given scopolamine often have short-term memory loss and cannot recall events while they are under the influence of the drug. Other experiments hav ...
Memory and Acetylcholine
... and learning. The prime example of this involvement is seen with scopolamine which is known to block muscarinic subtype of acetylcholine receptors. Those given scopolamine often have short-term memory loss and cannot recall events while they are under the influence of the drug. Other experiments hav ...
... and learning. The prime example of this involvement is seen with scopolamine which is known to block muscarinic subtype of acetylcholine receptors. Those given scopolamine often have short-term memory loss and cannot recall events while they are under the influence of the drug. Other experiments hav ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.