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Chapter 5 Over the counter drugs[1].
Chapter 5 Over the counter drugs[1].

... 1. Liquorice or plant extract: They are irritants of the gastric mucosa and they stimulate the afferent fibers of the vagus nerve to the medulla. This results in increased parasympathetic stimulation of the efferent fiber of the vagus nerve back to the stomach. Vagal stimulation to the lungs increa ...
Metabolic Disorders/ Cardiovascular Disease PPAR
Metabolic Disorders/ Cardiovascular Disease PPAR

... EC50 PPARγ = 470µM PPARα = 38%@200µM PPARδ = >>200µM ...
Antidepressants and neuroleptic
Antidepressants and neuroleptic

... brain. atypical drug clozapine has higher affinity for the D4 receptor and lower affinity for the D2 receptor, which may partially explain its minimal ability to cause extrapyramidal side effects (EPS). ...
Asthma
Asthma

... Used for nocturnal asthma (long acting relievers) ...
PPT
PPT

lec#8 done by Ghaida`a Abuzahra and Nahla
lec#8 done by Ghaida`a Abuzahra and Nahla

... reaching the point with no further response is achieved , this point is the (Vmax). There are specific number of receptors at the site of action . At the Vmax → all receptors are occupied with the drug. And sometimes we reach the Vmax without full occupancy of receptors , eg: Insulin hormone . * ins ...
4.Geetha T. S and Geetha N - International Journal of Pharmacy and
4.Geetha T. S and Geetha N - International Journal of Pharmacy and

• - MSON2014
• - MSON2014

... junction, or muscle tissue Direct-Acting Antispasmodics – dantrolene (Dantrium); produce an antispasmodic effect at the level of the neuromuscular junction and skeletal muscle Treating Muscle Spasms directly @ the Muscle Tissue o Dantrolene  relieves spasticity by interfering with the release of Ca ...
Plasma Protein Binding
Plasma Protein Binding

Drugs used to Treat Depression
Drugs used to Treat Depression

... • DHEA – a major glucorticoid hormone secreted by the adrenal glands, function unclear – Precursor to estrogen and testosterone – Increases feelings of physical and psychological wellbeing • SAM, SAMe – plays key intermediary role in many metabolic reactions that involve the transfer of the methyl g ...
Document 1 - Dania Beach e
Document 1 - Dania Beach e

... “poor quality control: toxic contaminants, albeit at low levels; misrepresentation of the nicotine delivered; and insufficient evidence of the overall public health benefit”; and WHEREAS, along with the FDA’s publicly expressed concerns over the safety of these devices, the FDA is continuing its off ...
Detox Medications
Detox Medications

... • They are commonly used for : – Insomnia = hypnotic – Acute anxiety, = anxiolytic – Anticonvulsants – Muscle relaxants – Agitation /anxiety in AXIS I disorders= sedative ...
Barbiturates, General Anesthetics, and Antiepileptic Drugs Laureen Trail
Barbiturates, General Anesthetics, and Antiepileptic Drugs Laureen Trail

OPIATE ANALGESICS AND ANTAGONISTS
OPIATE ANALGESICS AND ANTAGONISTS

Drugs - The Ramirez Group
Drugs - The Ramirez Group

... Truism of the day Off-label use (use by patients not diagnosed as requiring treatment) has not been subjected to long-term longitudinal studies. Absence of evidence (of long-term harm) is NOT evidence of absence ...
this PDF file - Journal of the Indian Institute of Science
this PDF file - Journal of the Indian Institute of Science

... (3) The existence of specific antagoaiats, such as naloxone and others, which block not only the actions of morphine, but also of many other classes of narcotic analgesics. (4) The fact that small structural changes, which are likely to alter the phya~cnlproperties of the ~noleculein only minor degr ...
Effects
Effects

... antagonist opposes the pharmacological action of the agonist. Competitive antagonism can be overcome by increasing the concentration of the agonist at the receptor site. (Example: Acetylcholine and atropine antagonism at muscarinic receptors). ...
6-作用于神经系统的药物
6-作用于神经系统的药物

... im: slow and irregular: im× (2)Elimination: t1/2= 44 ±13 hr, its metabolites are demethyldiazepam (去甲西泮) and oxazepam(奥沙西泮), they have pharmacological activity. Diazepam can be secreted from milk, to inhibit CNS of baby. ...
Observed Drug-Receptor Association Rates Are Governed by
Observed Drug-Receptor Association Rates Are Governed by

“Drugs of Abuse” Chart, Neil 9e KEY
“Drugs of Abuse” Chart, Neil 9e KEY

... (THC) in Cannabis sativa, A.K.A. marijuana ...
The Efficacy of Synthetic Steroids to Inhibit Hormonal
The Efficacy of Synthetic Steroids to Inhibit Hormonal

...  Greater the side chain length = greater affinity ...
*.. l-\
*.. l-\

Metabolism - Wayne State University
Metabolism - Wayne State University

... Excretion occurs in the liver. For benzodiazepines, some of the drugs actually get metabolized into active metabolites and therefore have a long half life leading to excessive sedation, while others with short half lives are directly conjugated into glucuronides and thus inactive immediately, theref ...
Opioid-Induced Nausea
Opioid-Induced Nausea

... 125mg PO day one prior to chemo,  then 80 mg daily in the morning for 2  more days   1. Phenothiazines can cause extrapyramidal symptoms including dystonia  and/or tardive dyskinesia  2. There is an increased risk of cardiotoxicity and prolongation of the QT interval with droperidol.  Droperidol sho ...
10-6-2016 PPT
10-6-2016 PPT

...  In the aspirin phenytoin example, aspirin increased the fup of phenytoin. Why was the LD not changed?  In the aspirin phenytoin example, aspirin increase the fup of phenytoin. Why was the MD not changed?  If fu increases, what happens to Clu? CL?  What is CLu a measure of? ...
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Nicotinic agonist



A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.
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