The impact of pharmacogenetics on the development and use of
... The pharmacogenetics of antipsychotic drug action has concentrated primarily on investigation of common variations in the DNA sequence (polymorphisms) in genes that have been implicated by the known pharmacology and neurochemical mechanisms of these drugs (reviewed in [4]). The target receptors for ...
... The pharmacogenetics of antipsychotic drug action has concentrated primarily on investigation of common variations in the DNA sequence (polymorphisms) in genes that have been implicated by the known pharmacology and neurochemical mechanisms of these drugs (reviewed in [4]). The target receptors for ...
- Institute for Theoretical Biology - Humboldt
... Almost all major recreational drugs, including caffeine, nicotine, delta-9-tetrahydrocannabinol (THC, the active ingredient in cannabis), cocaine, amphetamines, and heroin (but excepting alcohol) are plant neurotoxins or, in the case of several synthetic drugs, their close chemical analogs.1 These d ...
... Almost all major recreational drugs, including caffeine, nicotine, delta-9-tetrahydrocannabinol (THC, the active ingredient in cannabis), cocaine, amphetamines, and heroin (but excepting alcohol) are plant neurotoxins or, in the case of several synthetic drugs, their close chemical analogs.1 These d ...
Mechanism of Actions of Antidepressants: Beyond the Receptors
... (norepinephrine) reuptake inhibitor. Pharmacologically and chemically unrelated to TCA or SSRIs, reboxetine has significant affinity for the noradrenaline transporter, and little affinity for other neuroreceptors including serotonin, dopamine, histamine, muscarinergic and alpha adrenergic sites. NE ...
... (norepinephrine) reuptake inhibitor. Pharmacologically and chemically unrelated to TCA or SSRIs, reboxetine has significant affinity for the noradrenaline transporter, and little affinity for other neuroreceptors including serotonin, dopamine, histamine, muscarinergic and alpha adrenergic sites. NE ...
4) Van der waals interaction
... 2) Ionic Interaction: second strongest interaction strength (difference in enthalpy) = around (-5) 3) Dipole – Dipole interaction: Permanent partial charge (- δ, + δ) Must have an electronegative ion and a neutral atom ** Hydrogen bond is a special case from the Dipole – Dipole interaction -Hydrogen ...
... 2) Ionic Interaction: second strongest interaction strength (difference in enthalpy) = around (-5) 3) Dipole – Dipole interaction: Permanent partial charge (- δ, + δ) Must have an electronegative ion and a neutral atom ** Hydrogen bond is a special case from the Dipole – Dipole interaction -Hydrogen ...
IDENTIFICATION OF DUAL AGONISTIC NOVEL LIGANDS FOR INSULIN RECEPTOR AND... THROUGH MOLECULAR DOCKING
... insulin receptor and could be able promote the insulin signaling pathway. At the same time only 2 compounds are docked with PPARγ and could be able to promote PPAR signaling pathway. Hence it is clear that these 2 compounds could phosphorlyate both the insulin receptor and PPARγ there by providing s ...
... insulin receptor and could be able promote the insulin signaling pathway. At the same time only 2 compounds are docked with PPARγ and could be able to promote PPAR signaling pathway. Hence it is clear that these 2 compounds could phosphorlyate both the insulin receptor and PPARγ there by providing s ...
Nonopioid and Neuropathy-Specific Analgesic Action
... mg/kg were almost of same level. Nefiracetam-induced analgesic action after p.o. administration persisted for more than an hour (Fig. 2A). However, nefiracetam, after 30-mg/kg p.o. administration, had no effect in sham-operated mice (Fig. 2B). Similarly, intrathecal (i.t.) injection of 1 and 10 nmol ...
... mg/kg were almost of same level. Nefiracetam-induced analgesic action after p.o. administration persisted for more than an hour (Fig. 2A). However, nefiracetam, after 30-mg/kg p.o. administration, had no effect in sham-operated mice (Fig. 2B). Similarly, intrathecal (i.t.) injection of 1 and 10 nmol ...
Beta-Adrenergic Receptors, from Their Discovery and
... well with systemic or coronary sinus plasma norepinephrine concentrations. Many of the changes to the AR pathways associated with heart failure are also produced by the normal process of aging. There is also a good correlation between 1-AR density and age; the older the individual, the lower the  ...
... well with systemic or coronary sinus plasma norepinephrine concentrations. Many of the changes to the AR pathways associated with heart failure are also produced by the normal process of aging. There is also a good correlation between 1-AR density and age; the older the individual, the lower the  ...
Adverse effects - Nursing Pharmacology
... • Primary use: treatment of fever and to relieve pain • Adverse effects: uncommon with therapeutic doses ...
... • Primary use: treatment of fever and to relieve pain • Adverse effects: uncommon with therapeutic doses ...
Pharmacological treatment of schizophrenia–a review of progress
... evidence suggests that there may be a role for noradrenaline in the pathophysiology of schizophrenia, however, it is not clear how this happens and what role the different adrenergic receptors play. Current development and future directions Currently, several pharmaceutical companies have novel agen ...
... evidence suggests that there may be a role for noradrenaline in the pathophysiology of schizophrenia, however, it is not clear how this happens and what role the different adrenergic receptors play. Current development and future directions Currently, several pharmaceutical companies have novel agen ...
New pharmacological technologies in the clinical management of
... Buprenorphine : The agonist effects of buprenorphine (32 mg) increase linearly with increasing doses until it reache a plateau and no longer continue to develop respiratory depression with further doses, meaning “ceiling effect”. A compound that has an affinity for & stimulates physiological act ...
... Buprenorphine : The agonist effects of buprenorphine (32 mg) increase linearly with increasing doses until it reache a plateau and no longer continue to develop respiratory depression with further doses, meaning “ceiling effect”. A compound that has an affinity for & stimulates physiological act ...
Unit I
... b) List the two principle aims of the Harrison Act. c) Describe the regulatory function of the Controlled Substance Act. d) List three features of recent conceptions of addiction. e) Distinguish between substance abuse and substance dependence. f) Summarize the information in Figures 8.4 and 8.5. g) ...
... b) List the two principle aims of the Harrison Act. c) Describe the regulatory function of the Controlled Substance Act. d) List three features of recent conceptions of addiction. e) Distinguish between substance abuse and substance dependence. f) Summarize the information in Figures 8.4 and 8.5. g) ...
Functional assays for screening GPCR targets
... There are several new paradigms regarding GPCR activation, signaling and regulation that should be considered when developing GPCR functional assays (Figure 3). The choice of a cell line for recombinant receptor expression can be an important consideration for several reasons. First, most GPCRs unde ...
... There are several new paradigms regarding GPCR activation, signaling and regulation that should be considered when developing GPCR functional assays (Figure 3). The choice of a cell line for recombinant receptor expression can be an important consideration for several reasons. First, most GPCRs unde ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.