The Design and Synthesis of Novel Antimicrobial Agents for Use in
... a glimmer of hope was seen. That agent was Prontosil, and it was discovered by Gerhard Domagk in 1935.1-3 Prontosil was later found to be a prodrug that was metabolized in vivo to its active metabolite sulfanilamide (Figure 1.1).4 Prontosil was the first of the “sulfa” drugs discovered, and its disc ...
... a glimmer of hope was seen. That agent was Prontosil, and it was discovered by Gerhard Domagk in 1935.1-3 Prontosil was later found to be a prodrug that was metabolized in vivo to its active metabolite sulfanilamide (Figure 1.1).4 Prontosil was the first of the “sulfa” drugs discovered, and its disc ...
Theranostics Novel Linear Peptides with High Affinity to αvβ3
... Development of alternative linear peptides for targeting αvβ3 integrin has attracted much attention, as the traditional peptide ligand, cyclic RGD, is limited by inferior water-solubility and complex synthesis. Using pharmacophore-based virtual screening and high-throughput molecular docking, we ide ...
... Development of alternative linear peptides for targeting αvβ3 integrin has attracted much attention, as the traditional peptide ligand, cyclic RGD, is limited by inferior water-solubility and complex synthesis. Using pharmacophore-based virtual screening and high-throughput molecular docking, we ide ...
Professional Perspectives On Addiction Medicine
... Remnants of hemp ropes have been found in Iceland, carried there by the Vikings who were seeking other places to locate their homes. Cannabis seeds and cloth made of hemp have been found on Viking ships that have been dated to the 9th Century. The Italians were also a formidable sea power during the ...
... Remnants of hemp ropes have been found in Iceland, carried there by the Vikings who were seeking other places to locate their homes. Cannabis seeds and cloth made of hemp have been found on Viking ships that have been dated to the 9th Century. The Italians were also a formidable sea power during the ...
PHL 424 5th S
... Clindamycin generally is similar to erythromycin in its in vitro activity against susceptible strains of gram -positive cocci (pneumococci and streptococci) Some strains of streptococci that are macrolide-resistant remain susceptible to clindamycin Clindamycin is more active than erythromycin or c ...
... Clindamycin generally is similar to erythromycin in its in vitro activity against susceptible strains of gram -positive cocci (pneumococci and streptococci) Some strains of streptococci that are macrolide-resistant remain susceptible to clindamycin Clindamycin is more active than erythromycin or c ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Ensure that the patient knows the correct time intervals for inhalers Provide a spacer if the patient has difficulty coordinating breathing with inhaler ...
... Ensure that the patient knows the correct time intervals for inhalers Provide a spacer if the patient has difficulty coordinating breathing with inhaler ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... chemotherapy for a few weeks and has had no nausea or vomiting since then. However, he is taking dronabinol twice a day. The reason for the dronabinol order is to A. prevent recurrence of the chemotherapy-induced nausea and vomiting. B. prevent stress ulcers. C. improve his mood. ...
... chemotherapy for a few weeks and has had no nausea or vomiting since then. However, he is taking dronabinol twice a day. The reason for the dronabinol order is to A. prevent recurrence of the chemotherapy-induced nausea and vomiting. B. prevent stress ulcers. C. improve his mood. ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... chemotherapy for a few weeks and has had no nausea or vomiting since then. However, he is taking dronabinol twice a day. The reason for the dronabinol order is to A. prevent recurrence of the chemotherapy-induced nausea and vomiting. B. prevent stress ulcers. C. improve his mood. ...
... chemotherapy for a few weeks and has had no nausea or vomiting since then. However, he is taking dronabinol twice a day. The reason for the dronabinol order is to A. prevent recurrence of the chemotherapy-induced nausea and vomiting. B. prevent stress ulcers. C. improve his mood. ...
iPPI small molecule inhibitor of Protein
... taking place. Indeed, PPI, by their implication in numerous cellular mechanisms are more and more linked to a growing number of diseases and therefore represent a remarkable pool of putative therapeutic targets. With an estimation ranging from 130,000[1] to about 650,000[2] PPI in human, excluding t ...
... taking place. Indeed, PPI, by their implication in numerous cellular mechanisms are more and more linked to a growing number of diseases and therefore represent a remarkable pool of putative therapeutic targets. With an estimation ranging from 130,000[1] to about 650,000[2] PPI in human, excluding t ...
Short communication
... The serotonin neurotransmitter system plays an important role in many psychiatric and neurological disorders. As a modulator of extracellular serotonin levels and the site of action of many antidepressant drugs, the serotonin transporter (SERT) has been the focus of intense study for many years. Ima ...
... The serotonin neurotransmitter system plays an important role in many psychiatric and neurological disorders. As a modulator of extracellular serotonin levels and the site of action of many antidepressant drugs, the serotonin transporter (SERT) has been the focus of intense study for many years. Ima ...
neuro 2007 - addiction education home
... The aim of this study was to assess the effects of prenatal exposures to cannabinoids or carbon monoxide (CO) in an animal experimental model reproducing the environmental conditions in which a fetus develops whose mother, during pregnancy, ingests by smoking low doses of cannabinoids or CO. Particu ...
... The aim of this study was to assess the effects of prenatal exposures to cannabinoids or carbon monoxide (CO) in an animal experimental model reproducing the environmental conditions in which a fetus develops whose mother, during pregnancy, ingests by smoking low doses of cannabinoids or CO. Particu ...
Introduction
... terpenoid derivative Δ9-THC were dued by its hydrophobic nature that might act by influencing membrane fluidity, rather than combining with a specific receptor. However, by the mid 1980’s, several groups had shown that cannabinoid activity was highly stereospecific (Razdan, 1986) which led to the se ...
... terpenoid derivative Δ9-THC were dued by its hydrophobic nature that might act by influencing membrane fluidity, rather than combining with a specific receptor. However, by the mid 1980’s, several groups had shown that cannabinoid activity was highly stereospecific (Razdan, 1986) which led to the se ...
GPCR endocytosis confers uniformity in responses to chemically
... recognized that there are multiple sources of functional diversity at GPCRs, involving not only equilibrium affinity and intrinsic efficacy of the drug, but also kinetics of the drug-GPCR interaction and an extended theoretical formulation of intrinsic efficacy that is now called functional selectiv ...
... recognized that there are multiple sources of functional diversity at GPCRs, involving not only equilibrium affinity and intrinsic efficacy of the drug, but also kinetics of the drug-GPCR interaction and an extended theoretical formulation of intrinsic efficacy that is now called functional selectiv ...
Analysing the effect of I1 imidazoline receptor ligands on DSS
... Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases, and moxonidine and rilmenidine, agonists of I1-IRs are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or ...
... Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases, and moxonidine and rilmenidine, agonists of I1-IRs are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or ...
Update on Marijuana and Cannabinoid
... 1) Oral CBD is a safe medication in a tolerant population in the dose range tested (up to 800 mg) 2) CBD does not display abuse liability a marijuana-abusing population 3) CBD was placebo-like on all measures tested and there was no signal for CBD to decrease marijuana subjective effects 4) In t ...
... 1) Oral CBD is a safe medication in a tolerant population in the dose range tested (up to 800 mg) 2) CBD does not display abuse liability a marijuana-abusing population 3) CBD was placebo-like on all measures tested and there was no signal for CBD to decrease marijuana subjective effects 4) In t ...
Prescribing Information
... Therefore, the same types of adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions including death due to bronchospasm in patients with asthma, and rarely death in ...
... Therefore, the same types of adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions including death due to bronchospasm in patients with asthma, and rarely death in ...
Application for the removal of "Antacids" from the WHO Model List of
... effect which is particularly important in patients with peptic ulcer disease. The optimum pH for pepsin activity is 1.5–2.5 and progressive inhibition occurs as gastric pH increases; above pH 4, the proteolytic activity of pepsin is minimal. Antacids do not coat the lining of peptic ulcers or the GI ...
... effect which is particularly important in patients with peptic ulcer disease. The optimum pH for pepsin activity is 1.5–2.5 and progressive inhibition occurs as gastric pH increases; above pH 4, the proteolytic activity of pepsin is minimal. Antacids do not coat the lining of peptic ulcers or the GI ...
UTEROTONIC PROPERTIES OF NYMPHAEA ALBA ON ISOLATED MYOMETRIUM MODEL Original Article
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
pharm chapter 22 [9-2
... vascular endothelial cells, smooth muscle cells, and fibroblasts – activation of thrombin receptor involves proteolytic cleavage of extracellular domain of receptor by thrombin, and a new NH2-terminaltethered ligand binds intramolecularly to a discrete site within receptor and initiates intracellula ...
... vascular endothelial cells, smooth muscle cells, and fibroblasts – activation of thrombin receptor involves proteolytic cleavage of extracellular domain of receptor by thrombin, and a new NH2-terminaltethered ligand binds intramolecularly to a discrete site within receptor and initiates intracellula ...
Diterpenes-A Review on Therapeutic uses with special emphasis on
... effectively address the problem of mealtime high glucose levels (Gerstein et.al., 2008.; Holman et.al., 2007) that have been shown to trigger atherogenic processes. Looking at the bottom of T2DM, it is essential to improve ß-cell function and mass which would enable improved insulin sensitivity and ...
... effectively address the problem of mealtime high glucose levels (Gerstein et.al., 2008.; Holman et.al., 2007) that have been shown to trigger atherogenic processes. Looking at the bottom of T2DM, it is essential to improve ß-cell function and mass which would enable improved insulin sensitivity and ...
Therapeutic applications of ricin and some alkaloids
... reacted with CD5 and got partial responses in four patients. R-immunotoxins still have a long way to go, before they can be used as successful therapeutics because of their high toxicity. There are several reports of using R-immunotoxins to treat cancers and many a times the clinical trials were dis ...
... reacted with CD5 and got partial responses in four patients. R-immunotoxins still have a long way to go, before they can be used as successful therapeutics because of their high toxicity. There are several reports of using R-immunotoxins to treat cancers and many a times the clinical trials were dis ...
CHANGES AND CHALLENGES: GIST, MUTATED c-KIT AND IMATINIB RESISTANCE Sabrina Pricl
... As seen for the analogous mutation T315I in the ABL kinase domain (6), in a sort of a domino effect the substitution of this single residue in this position induces several, sometimes substantial modifications in the conformation of other residues, both belonging to the binding site and the surround ...
... As seen for the analogous mutation T315I in the ABL kinase domain (6), in a sort of a domino effect the substitution of this single residue in this position induces several, sometimes substantial modifications in the conformation of other residues, both belonging to the binding site and the surround ...