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Asthma - diagnosis and monitoring
Asthma - diagnosis and monitoring

... This guideline offers best practice advice on the care of adults, young people and children with suspected asthma or with a confirmed diagnosis of asthma. Patients and healthcare professionals have rights and responsibilities as set out in the NHS Constitution for England – all NICE guidance is writ ...
Effect of different asthma treatments on risk of cold-related exacerbations
Effect of different asthma treatments on risk of cold-related exacerbations

... controlled trials [21–25], uses budesonide/formoterol as maintenance therapy, with extra inhalations of budesonide/formoterol (80/4.5 or 160/4.5 mg) as needed for relief of asthma symptoms, regardless of their cause. The ‘‘action plan’’ for this treatment regimen thus includes an increase in ICS and ...
A summary of the new GINA strategy:
A summary of the new GINA strategy:

... of asthma diagnosis, for use in clinical practice or clinical research. Other tests used in diagnosis of asthma are described in the report and appendix, with a reminder that statements in the literature about the sensitivity and specificity of “diagnostic” tools must be interpreted in the light of ...
Asthma - Minnesota Department of Health
Asthma - Minnesota Department of Health

... Asthma:  Accounts for 14 million lost school days annually3  Is the most common chronic disease causing absence from school2  Is the 3rd leading cause of hospitalizations among children under 152  1 in 13 school children have asthma1  6.3 million children under 18 have asthma1 1 Asthma Prevale ...
Asthma - Minnesota Department of Health
Asthma - Minnesota Department of Health

... Asthma:  Accounts for 14 million lost school days annually3  Is the most common chronic disease causing absence from school2  Is the 3rd leading cause of hospitalizations among children under 152  1 in 13 school children have asthma1  6.3 million children under 18 have asthma1 1 Asthma Prevale ...
Asthma as a Cause of Death
Asthma as a Cause of Death

... have been identified in cases of near-fatal and fatal asthma. Such factors include the underuse of inhaled corticosteroids (20,31) and delay in initiating oral corticosteroids during an acute attack (20). Lack of appropriate medical care (32), limited use of primary care services (33), and failure t ...
Time to death, airway wall inflammation and remodelling in fatal asthma
Time to death, airway wall inflammation and remodelling in fatal asthma

... treatment and the effects of patient variables such as obesity and other illness, especially in older subjects. These confounders might be expected to be distributed continuously. The dichotomy of times which is clearly evident in four different series of fatal asthma cases is, therefore, interestin ...
Confirmation of asthma in an era of overdiagnosis V.P. Luks*, K.L. Vandemheen
Confirmation of asthma in an era of overdiagnosis V.P. Luks*, K.L. Vandemheen

... V.P. LUKS ET AL. ...
Exercise-induced asthma - The American Academy of Allergy
Exercise-induced asthma - The American Academy of Allergy

... occurring after a burst (eg, 6-8 minutes) of strenuous and continuous aerobic exercise.34,35 In elite athletes such as female hockey players, Rundell et al36 found that cough was the most frequent symptom and developed significantly more frequently than wheeze or excess mucus (P < .05). Symptoms wer ...
Exhaled nitric oxide and asthma control:
Exhaled nitric oxide and asthma control:

... allergic status was evaluated using skin prick test or radioallergosorbent test against common inhalant allergens. Patients were asked not to use b2-agonists 6 h prior to visits to the clinic. The present study was approved by the local ethics committee and patients signed an informed consent form. ...
online supplement
online supplement

... safety during phase 1, subjects were provided with individualized action plans, prednisolone tablets for emergency use, and an emergency contact details card. Subjects were contacted at regular intervals during the period off treatment and in addition subjects had 24-hour access to a study investiga ...
Is ventilation heterogeneity related to asthma control? Sarah Svenningsen , Parameswaran Nair
Is ventilation heterogeneity related to asthma control? Sarah Svenningsen , Parameswaran Nair

... The primary goal of asthma therapy is to achieve and maintain disease control. Unfortunately, ∼50% of asthma patients remain poorly controlled with up to 10% of these patients experiencing life-threatening exacerbations [1]. The clinical and pathophysiological findings in poorly controlled asthma ar ...
Traditional and patient-centred outcomes with three classes of asthma medication C.R. Jenkins*
Traditional and patient-centred outcomes with three classes of asthma medication C.R. Jenkins*

... in, and relationships between, traditional and patient-centred end-points during treatment with three classes of asthma medication. Subjects with mild-to-moderate asthma were randomised to double-blind, double-dummy crossover treatment with eformoterol 12 mg b.i.d. or montelukast 10 mg q.d., then si ...
Wheeze in infants and young children Diagnoses and management options
Wheeze in infants and young children Diagnoses and management options

... ing one day of runny nose. In results in infants have been very between these episodes he some- mixed8 (Misconception 4). In my times gets wheezy on cold days. search of studies trialling inhaled Both parents are on preventive steroids in children under 24 months treatment for asthma, but neither I ...
Minnesotans with asthma will have healthy environments and will
Minnesotans with asthma will have healthy environments and will

Sudden-onset asthma exacerbations: clinical features, response to therapy, and 2-week follow-up
Sudden-onset asthma exacerbations: clinical features, response to therapy, and 2-week follow-up

... In the 4 weeks preceding presentation, proportions using inhaled b-agonists, inhaled corticosteroids and systemic corticosteroids were virtually the same, however a higher proportion of patients with sudden onset used oral bagonists. The sudden-onset group exhibited a trend toward using more salmete ...
Peak Performance USA: Asthma Diagnosis and Management
Peak Performance USA: Asthma Diagnosis and Management

... in the better delivery of pMDI medication:  A VHC can assist individuals who have difficulty coordinating actuation of the pMDI with breathing.  A VHC can also help individuals avoid common breathing mistakes when using a pMDI, such as breathing too fast, too shallow, or through the nose.  A VHC ...
An unexpected role for serum uric acid as a biomarker for severity of
An unexpected role for serum uric acid as a biomarker for severity of

... Our study is the first to report the change in circulating UA levels in asthma exacerbation patients, because previous studies have only noted changes in UA levels in BAL fluid following allergen challenge.5-9 This study demonstrates that sUA levels are significantly higher in patients experiencing ...
Peak Performance USA: Asthma Diagnosis and Management
Peak Performance USA: Asthma Diagnosis and Management

... ● Yellow – 50 to 80% of personal best: signals caution: an acute exacerbation may be present and a temporary increase in medication may be indicated. Overall asthma may not be in sufficient control, and maintenance therapy may need to be increased or additional short-term medication may be indicated ...


... with chronic severe asthma, defined by the requirement for daily prophylaxis with inhaled corticosteroids at doses >500 µg·day-1. There was a significant correlation between peak flow, symptoms and bronchodilator use in 70–80% of this severe group, compared with 22–55% in the mild and moderate group ...
PDF full-Text
PDF full-Text

... (Ig) E antibodies followed by a gradual decrease over months or years of treatment without abolishing totally the immediate cutaneous reactivity has been reported [2]. However, changes in serum allergen-specific IgE are poorly correlated with clinical improvement, especially with regard to respirato ...
Asthma severity and medical resource utilisation
Asthma severity and medical resource utilisation

... strongly associated with the severity of the disease [6, 7]. However, cost-of-illness data for asthma cannot be directly extrapolated from one country to another because there is considerable variation in the total mean annual cost per affected person by country [6]. Although some of this reported v ...
Suboptimal asthma control: prevalence, detection and consequences in general practice
Suboptimal asthma control: prevalence, detection and consequences in general practice

... The present findings confirm and extend the previous examinations of asthma control in practice settings. First, using a relatively unbiased general practice sample of patients in Canada, it has been confirmed that the majority of patients do not enjoy adequate guideline-defined asthma control. Seco ...
PHENOTYPING REVIEW Clean - Spiral
PHENOTYPING REVIEW Clean - Spiral

... asthma phenotypes. Understanding the underlying mechanisms driving these clusters may lead to better patient orientated medicines. Recent findings: Clustering was initially performed on clinical features only but the addition of biomarkers that characterise sputum and blood cellular profiles have en ...
Asthma Lesson Plan
Asthma Lesson Plan

... § Discuss with student that s/he should feel comfortable participating in gym, but should also feel comfortable “sitting out” if s/he is having difficulty with his asthma § (Note: interesting that many famous athletes (including Jackie Joyner-Kersie, Emmitt Smith) have asthma Scenario II: A student ...
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Omalizumab

Omalizumab (trade name Xolair, Roche/Genentech and Novartis) is a humanized antibody originally designed to reduce sensitivity to inhaled or ingested allergens, especially in the control of moderate to severe allergic asthma, which does not respond to high doses of corticosteroids. It has been approved for treating adult and adolescent patients 12 years and older with severe or moderate to severe allergic asthma in more than 90 countries, since its first of such approval in 2002 in Australia. Omalizumab was approved in March 2014 in the European Union and the U.S.A. and in about 10 other countries for treating patients 12 years and above with chronic spontaneous urticaria (CSU) (also referred to as chronic idiopathic urticaria or CIU), which cannot be treated with H1-antihistamines. CSU is not an allergic disease. Presently, the drug is being actively studied in clinical trials for various allergic diseases and some non-allergic diseases, especially skin diseases.Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, it does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells.IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. Allergy occurs more frequently in individuals with higher serum IgE levels, though some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems.
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