Industrial Biotechnology
... • The final product of metabolic pathway inhibits the action of earlier enzymes (usually the first) of that sequence. • The inhibitor and the substrate need not resemble each other, hence the inhibition is often called allosteric. • In case of isosteic inhibition the inhibitor and substrate have the ...
... • The final product of metabolic pathway inhibits the action of earlier enzymes (usually the first) of that sequence. • The inhibitor and the substrate need not resemble each other, hence the inhibition is often called allosteric. • In case of isosteic inhibition the inhibitor and substrate have the ...
Access Slides - Science Signaling
... (A) Depiction of the putative mechanism by which PTP1B causes resistance to leptin signaling believed to occur in dietinduced obesity. Although leptin binds normally to its cell surface receptor (1) and phosphorylates Jak2 (2), the receptor complex comes into proximity with PTP1B on the ER (3). Ther ...
... (A) Depiction of the putative mechanism by which PTP1B causes resistance to leptin signaling believed to occur in dietinduced obesity. Although leptin binds normally to its cell surface receptor (1) and phosphorylates Jak2 (2), the receptor complex comes into proximity with PTP1B on the ER (3). Ther ...
Patrick_Chapter_5
... - strong enough to hold the messenger sufficiently long for signal transduction to take place - weak enough to allow the messenger to depart Implies a fine balance Drug design - designing molecules with stronger binding interactions results in drugs that block the binding site antagonists ...
... - strong enough to hold the messenger sufficiently long for signal transduction to take place - weak enough to allow the messenger to depart Implies a fine balance Drug design - designing molecules with stronger binding interactions results in drugs that block the binding site antagonists ...
New concepts of cellular fatty acid uptake: role of fatty acid transport
... Evidence is emerging that proteins are important mediators of LCFA-trafficking into cells and various proteins have been suggested to be involved in this process. Amongst these proteins is a family of membrane-associated proteins termed fatty acid transport proteins (FATP). So far six members of thi ...
... Evidence is emerging that proteins are important mediators of LCFA-trafficking into cells and various proteins have been suggested to be involved in this process. Amongst these proteins is a family of membrane-associated proteins termed fatty acid transport proteins (FATP). So far six members of thi ...
Describe how cells are used in the production of
... • 2 molecules of ATP formed in the first stage. • Oxygen in not required for this stage. (maximum of two) • In this second stage pyruvic acid is broken down into carbon dioxide and water. • Second stage can only happen in the presence of oxygen. • 36 molecules of ATP are formed in the second stage. ...
... • 2 molecules of ATP formed in the first stage. • Oxygen in not required for this stage. (maximum of two) • In this second stage pyruvic acid is broken down into carbon dioxide and water. • Second stage can only happen in the presence of oxygen. • 36 molecules of ATP are formed in the second stage. ...
Acetyl-CoA Carboxylase-A New Target in the Fight against Obesity
... Experiment on ACC1 and ACC2 ACC1 and ACC2 are the main enzymes in lipid metabolism. An experiment was conducted using mice to analyze the enzymes further and to compare ACC1 and ACC2.After the experiment was complete, the conclusion was that ACC2 played a role in decreasing intracellular fatty acid ...
... Experiment on ACC1 and ACC2 ACC1 and ACC2 are the main enzymes in lipid metabolism. An experiment was conducted using mice to analyze the enzymes further and to compare ACC1 and ACC2.After the experiment was complete, the conclusion was that ACC2 played a role in decreasing intracellular fatty acid ...
Medical Biochemistry: Course content 2016/2017
... body (structural formulas and principle), and what is the subcellular location? What fatty acid is primarily generated? What coenzymes are needed, and for NADPH, where is it formed (process)? Extension and introduction of double bonds in fatty acids, subcellular location, synthesis of arachidonic ac ...
... body (structural formulas and principle), and what is the subcellular location? What fatty acid is primarily generated? What coenzymes are needed, and for NADPH, where is it formed (process)? Extension and introduction of double bonds in fatty acids, subcellular location, synthesis of arachidonic ac ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
... (6) By placing oppositely charged amino acid residues at a proper distance from the ends of the α-helices, enzyme stability can be increased. (7) The transition state formed at the active site is a lower energy state than the reactants. (8) Lysozyme breaks down the peptidoglycan of bacterial cell wa ...
... (6) By placing oppositely charged amino acid residues at a proper distance from the ends of the α-helices, enzyme stability can be increased. (7) The transition state formed at the active site is a lower energy state than the reactants. (8) Lysozyme breaks down the peptidoglycan of bacterial cell wa ...
Lipid Biosynthesis
... A) Condensation of precursors. B) Rearrangement. C) Reduction. D) Dehydration. 3. Which of the following is the regulated step of fatty acid synthesis in eukaryotes? A) Carboxylation of acetyl CoA. B) Transportation of mitochondrial acetyl CoA into the cytosol. C) Assembly of the fatty acid chain ...
... A) Condensation of precursors. B) Rearrangement. C) Reduction. D) Dehydration. 3. Which of the following is the regulated step of fatty acid synthesis in eukaryotes? A) Carboxylation of acetyl CoA. B) Transportation of mitochondrial acetyl CoA into the cytosol. C) Assembly of the fatty acid chain ...
File - Wk 1-2
... 1. The Ras/MAP kinase pathway the SH2 domain of the Grb2 protein (growth factor receptor binding protein) recognizes and binds the phosphorylated tyrosine residues on SHC SOS (a guanine nucleotide exchange factor – GEF) bound to GRB, then promotes the exchange of inactive GDP bound to Ras to GTP ...
... 1. The Ras/MAP kinase pathway the SH2 domain of the Grb2 protein (growth factor receptor binding protein) recognizes and binds the phosphorylated tyrosine residues on SHC SOS (a guanine nucleotide exchange factor – GEF) bound to GRB, then promotes the exchange of inactive GDP bound to Ras to GTP ...
PHYSIOLOGY LECTURE EXAM #1 REVIEW LIST
... -how does receptor-mediated endocytosis differ from phagocytosis? -what is a membrane/concentration gradient? What is a membrane potential – how is it ...
... -how does receptor-mediated endocytosis differ from phagocytosis? -what is a membrane/concentration gradient? What is a membrane potential – how is it ...
The Cell, 5e
... • IDL - produced in blood (remnant of VLDL) • LDL – produced in blood (remnant of IDL after TG digestion; high concentration of cholesterol; endocytosed by liver, other tissues (LDL receptor) • HDL – produced in liver, intestine; exchanges proteins and lipids with other lipoproteins; returns cholest ...
... • IDL - produced in blood (remnant of VLDL) • LDL – produced in blood (remnant of IDL after TG digestion; high concentration of cholesterol; endocytosed by liver, other tissues (LDL receptor) • HDL – produced in liver, intestine; exchanges proteins and lipids with other lipoproteins; returns cholest ...
Section VI. Lipid metabolism overview:
... • Chylomicrons – produced in intestinal cells from dietary fat; carry TG in blood • VLDL – produced from liver mainly from dietary carbohydrate; carries TG in blood • IDL - produced in blood (remnant of VLDL) • LDL – produced in blood (remnant of IDL after TG digestion; high concentration of cholest ...
... • Chylomicrons – produced in intestinal cells from dietary fat; carry TG in blood • VLDL – produced from liver mainly from dietary carbohydrate; carries TG in blood • IDL - produced in blood (remnant of VLDL) • LDL – produced in blood (remnant of IDL after TG digestion; high concentration of cholest ...
Gene Section IL22RA1 (interleukin 22 receptor, alpha 1)
... lymphoma cells allows these cells to be responsive to IL-22 stimulation, which further stimulate STAT3 signaling and the growth of these cells. Blocking the IL-22 signaling pathway using a neutralizing antibody has been shown to significantly decrease the growth of ALK+ALCL cells in-vitro. The aberr ...
... lymphoma cells allows these cells to be responsive to IL-22 stimulation, which further stimulate STAT3 signaling and the growth of these cells. Blocking the IL-22 signaling pathway using a neutralizing antibody has been shown to significantly decrease the growth of ALK+ALCL cells in-vitro. The aberr ...
Tutorial Kit (Biochemistry-300 L)
... 5. Discuss the role of amino acids in protein structure determination and function Protein structure is generated by 4 levels of structure – primary, secondary, tertiary and quartenary. The four levels are generated by interactions between constituent amino acids Primary structure is the linear seq ...
... 5. Discuss the role of amino acids in protein structure determination and function Protein structure is generated by 4 levels of structure – primary, secondary, tertiary and quartenary. The four levels are generated by interactions between constituent amino acids Primary structure is the linear seq ...
presentation source
... – selective barrier between cytoplasm and its contents and outside the cell. – Composed of phospholipid, other lipid material and proteins ...
... – selective barrier between cytoplasm and its contents and outside the cell. – Composed of phospholipid, other lipid material and proteins ...
biochem 33 [3-24
... packaging; depending on efficacy of LPL may have only elevated VLDL or elevated VLDL and LDL 17. How does the source of FAs for VLDL triacylglycerols differ b/t healthy and diabetics? a. In healthy ppl source is generally xs carbohydrates; for diabetics source is xs TAGs mobilized form adipose (will ...
... packaging; depending on efficacy of LPL may have only elevated VLDL or elevated VLDL and LDL 17. How does the source of FAs for VLDL triacylglycerols differ b/t healthy and diabetics? a. In healthy ppl source is generally xs carbohydrates; for diabetics source is xs TAGs mobilized form adipose (will ...
Purified Mouse Anti-p115 — 612260
... for vesicle transport from the cis-compartment to the medial-compartment. p115 protein is related to the yeast Uso1p essential for the vesicular transport from the endoplasmic reticulum to the Golgi. Native p115 appears to be a homo-oligomer, with two globular heads and a tail that resemble the over ...
... for vesicle transport from the cis-compartment to the medial-compartment. p115 protein is related to the yeast Uso1p essential for the vesicular transport from the endoplasmic reticulum to the Golgi. Native p115 appears to be a homo-oligomer, with two globular heads and a tail that resemble the over ...
Slide 1
... FIGURE 23-1: Stereo chemistry of the quantitatively major inositol lipids. Inositol lipids characteristically contain stearic acid (18:0) and arachidonic acid (20:4 ω6) esterified to the 1 and 2 position of sn-glycerolphosphate, respectively. The phosphate (colored circle) is diesterified to the 1 ...
... FIGURE 23-1: Stereo chemistry of the quantitatively major inositol lipids. Inositol lipids characteristically contain stearic acid (18:0) and arachidonic acid (20:4 ω6) esterified to the 1 and 2 position of sn-glycerolphosphate, respectively. The phosphate (colored circle) is diesterified to the 1 ...
No Slide Title
... the level of catecholaminergic neurotransmission. Neuropeptide Y (NPY) is a 36 amino acid peptide that is highly homologous to peptide YY (PYY). NPY exerts its various biological effects through at least six classes of receptors, designated Y1, Y2, Y3, Y4, Y5, and Y6. It has been demonstrated that N ...
... the level of catecholaminergic neurotransmission. Neuropeptide Y (NPY) is a 36 amino acid peptide that is highly homologous to peptide YY (PYY). NPY exerts its various biological effects through at least six classes of receptors, designated Y1, Y2, Y3, Y4, Y5, and Y6. It has been demonstrated that N ...
Nucleotide Metabolism
... • Over production of PRPP is one cause of gout because PRPP stimulates the next step… ...
... • Over production of PRPP is one cause of gout because PRPP stimulates the next step… ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.