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Transcript
Innovation in Translational Medicine
Cell-Based Therapeutics: Medicine’s Next Pillar
CALIS
Medical Libraries
Yinchuan Ningxia
2013
Science Flagship Publication
• Over 105,000 full-text articles in
the database, growing each
week
• Science has published articles
by over 150 Nobel Laureates
since 1977
• Science - 1 of 6 indicators to
rank world universities for the
Academic Ranking of World
Universities (ARWU)
• Impact Factor 31
2
• ISI Web of Knowledge
2011 Impact Factors
• Science Signaling: 7.5
• Science Translational
Medicine: 7.8
• New customer discount
07% for 2014-Sci
Trans Medicine
3
Cellular Engineering:
the Challenge of Controlling Cell’s Actions
4
The Beauty of Cells
• Cells naturally perform
therapeutic tasks
• Cell behavior is exquisitely
selective
• Cells are special delivery
agents
• Cells can handle human
genetic variability
• Cells behaviors can be
engineered
5
Killer Apps for Cell Therapy Will Address
Critical Unmet Needs of Human Disease
• Immune cells that seek
and destroy cancer
• Bacterial treatment for
Crohn’s disease
• Combination of
bacterial and
mammalian cell
therapeutics
6
Roadblocks for Cell Transplants
S. J. Sharkis et al., Sci Transl Med 2012;4:127ps9-127ps9
7
Published by AAAS
Challenges to Make Cell Therapeutics Safe
• Two major challenges – safety and efficacy
• The lifetimes of cells can be carefully
controlled
• US FDA will need well-defined safety criteria
for cell therapeutics for early movers to
invest in new companies
• Better odds in the therapeutic development
pipeline
Cell-based Therapeutics
The New Third Pillar of Medicine?
• A foundational science of
cellular engineering
• Key control modules
needed in the cellular
engineer’s toolbox
• Control over cell death via
safety switch mechanisms
• Ability to reprogram cell
communication
• Systematic strategies to
reshape cellular behaviors
9
Potential Rational Engineering of
Therapeutic Cells
Now is the time for the
designers of cellular
therapeutics to take the
systematic steps to lay
the solid foundation for
future therapeutic
industries.
10
Science Translational Medicine
Research from China
• Muscular Dystrophy
• Peking University 2012
• Cancer Leukemia
• CAS Institutes 2012
• Atherosclerosis
• BGI 2013
• Graft-Versus-Host Disease
• Guangzhou Medical College
2013
• Kidney Disease
• Shanghai Jiao Tong University
2013
11
Science Signaling - Research from China
• Innate &Adaptive Immune Responses
•
CAS Laboratory of Infection and
Immunity 2012
• Parkinson’s Disease
•
University of Science & Technology
•
Soochow University 2012
• Avian Influenza
•
Multi Institutions 2012
• Squamous Cell Carcinoma
•
Shanghai Jiaotong University
•
Capital University of Medical Sciences
12
NEW Science Translational Medicine
Educational Online Tutorial
Explore exciting content and
unique features:
• Navigate journal issues and
articles
• Search the site and more!
Visit ScienceOnline.org/tutorial
13
[email protected]
ScienceOnline.org/librarian
and
Kiki Forsythe
[email protected]
谢谢!
14