Download Autosomal Dominant

Affected
Phenotype
(capitalized is
dominant)
Carriers
Autosomal
Dominant
Autosomal
Recessive
X linked
Dominant
X linked
Recessive
Aa, AA
aa
yX, xX, XX
Yx
None
For stated
parent only
with affected
allele:
Females Only
For stated
parent only
with affected
allele:
0% Affected
0% Affected
100% Affected
0% Affected
100% Carriers
50% Affected
50% Affected
None
For
heterozygous
parents:
Father to Son
50% Affected
Father to
Daughter
50% Affected
Mother to Son
50% Affected
Mother to
Daughter
50% Affected
For
heterozygous
parents:
25% Affected
50% Carriers
25% Affected
50% Carriers
25% Affected
50% Carriers
25% Affected
50% Carriers
50% Affected
0% Affected
50% Carriers
Males get the
disease,
females are
carriers
Gender Bias
None
None
3 times as
many women
with the disease
as men
Inheritance
(when not from
spontaneous
mutation)
From parent(s)
with disease
From parent(s)
with disease or
carrier
From parent(s)
with disease
From mother carrier
1 in 4
Affected Father
Males: 0
Females: 1 in 1
Affected
Mother
1 in 2
Affected Father
0
Affected
Mother
Males: 1 in 2
Females: 0
Parents may be
consanguineous.
Asymptomatic
parents are carriers.
In rare conditions:
Affected females
are twice as
common as males
and have milder
expression.
If trait is lethal to
males:
heterozygous
females have 2:1
female:male
offspring
Affected males are
related through
females.
Heterozygous
females may show
variable
expression.
Recurrence for
Siblings of
Proband
Other
Information
1 in 2
Trait shows up
every generation.
Normal members
don’t transmit
trait.