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 MICRO 224: INTRODUCTION TO MICROBIAL PATHOGENESIS Course Director: Joy Sturtevant Faculty: MIP Graduate Faculty 45h class contact time Evaluation: 2 exams; 1 problem set; class participation Catalog Course Description This course will cover basic concepts of host-­‐microbe interactions that occur during infectious disease, including characteristics of bacteria, viruses, fungi, and parasites and how they manifest disease. It will emphasize the importance of pathogens, their diversity and mechanisms of pathogenesis. The course will conclude by reinforcing the common themes of infectious disease. Basic Concepts to be covered in course: • Host-­‐microbe interactions that occur during infectious disease. • How microbes interact with the host and manifest disease (or colonize) – Includes basic components of host immunity against microbial infection • Differences between bacteria, viruses, fungi and parasites – Concept of eukaryotic vs prokaryotic vs virus • Pathogens having the greatest impact on human health • Viruses, bacteria, and eukaryotic pathogens sharing common means to survive within the host Evaluations: • Host-­‐Pathogen interaction: • Take home assignment: Molecular Koch’s postulates: implications for the study of host-­‐
pathogen interactions/pathogenesis (10%) • Exam: short answer (40%) • Common themes in Microbial Pathogenesis: • Exam: essay (50%) • The final grade will be docked for each unexcused absence and for unexcused tardiness. Outcomes: • Host-­‐Pathogen interaction: – Appreciation of the medical importance of bacteria, viruses, fungi, and parasites and their impact on humans – Appreciation of how different microbes cause disease • Common themes – Appreciation that different types of pathogens have common mechanisms to affect disease outcome – Understanding that pathogens have evolved multiple mechanisms to survive within the host – Appreciation that antimicrobial therapeutic strategies can apply to multiple types of organism 1