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Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
Short Communication
RGS17 (regulator of G-protein signaling 17)
Chenguang Li, Lei Wang, Yihua Sun, Haiquan Chen
Department of Thoracic Oncology, Fudan University Shanghai Cancer Center and Department of Oncology,
Shanghai Medical College, Fudan University, Shanghai, 200032, China (CL, LW, YS, HC)
Published in Atlas Database: October 2011
Online updated version : http://AtlasGeneticsOncology.org/Genes/RGS17ID47522ch6q25.html
DOI: 10.4267/2042/47280
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
Description
Other names: RGS-17, RGSZ2, hRGS17
HGNC (Hugo): RGS17
Location: 6q25.2
The RGS17 protein consists of 210 amino acid
residues. This gene encodes a member of the regulator
of G-protein signaling family. This protein contains a
conserved, 120 amino acid motif called the RGS
domain and a cysteine-rich region.
DNA/RNA
Expression
Description
Widely expressed in human organs.
The RGS17 gene spans over a region of 120 kbp DNA
including 4 coding exons and 1 non-coding exon (exon
1).
Localisation
Transcription
Function
The RGS17 gene mRNA consists of about 1472
nucleotides with an open reading frame (ORF) of 633
bases.
The protein attenuates the signaling activity of Gproteins by binding to activated, GTP-bound G alpha
subunits and acting as a GTPase activating protein
(GAP), increasing the rate of conversion of the GTP to
GDP. RGS proteins are GTPase-activating proteins for
Gi and Gq class G-alpha proteins. They accelerate
transit through the cycle of GTP binding and hydrolysis
and thereby accelerate signaling kinetics and
termination. This hydrolysis allows the G alpha
subunits to bind G beta/gamma subunit heterodimers,
forming inactive G-protein heterotrimers, thereby
terminating the signal.
Its cellular localization has not been formally
monitored to date.
Pseudogene
RGS17P1 regulator
pseudogene 1.
of
G-protein
signaling
17
Protein
Note
210 amino acids; 24 kDa.
Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein
signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.
Atlas Genet Cytogenet Oncol Haematol. 2012; 16(3)
216
RGS17 (regulator of G-protein signaling 17)
Li C, et al.
Homology
Ovarian cancer
The RGS17 gene is conserved in chimpanzee, dog,
cow, mouse, rat, chicken, and zebrafish.
Disease
RGS2, RGS5, RGS10 and RGS17 transcripts are
expressed at significantly lower levels in cells resistant
to chemotherapy compared with parental, chemosensitive cells in ovarian cancer cells (Hooks et al.,
2010).
Prognosis
RGS17 loss of expression contributes to the
development of chemoresistance in ovarian cancer
cells.
Mutations
Germinal
No germline mutations in this gene have been reported.
Somatic
A synonymous-coding somatic mutations of this gene
is reported in pancreas cancer at codon 166, P166P
(COSMIC).
References
Implicated in
James MA, Lu Y, Liu Y, Vikis HG, You M. RGS17, an
overexpressed gene in human lung and prostate cancer,
induces tumor cell proliferation through the cyclic AMP-PKACREB pathway. Cancer Res. 2009 Mar 1;69(5):2108-16
Various cancer
Note
Lung cancer, prostate cancer.
Disease
RSG17 is overexpressed in lung and prostate cancer
(James et al., 2009). Expression of RGS17 is upregulated in 80% of lung tumors, and also up-regulated
in prostate tumors. Overexpression of RGS17 induce
and maintain cell proliferation.
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y,
Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, et al. Fine
mapping of chromosome 6q23-25 region in familial lung cancer
families reveals RGS17 as a likely candidate gene. Clin
Cancer Res. 2009 Apr 15;15(8):2666-74
Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, Murph
MM. Regulators of G-Protein signaling RGS10 and RGS17
regulate chemoresistance in ovarian cancer cells. Mol Cancer.
2010 Nov 2;9:289
Lung cancer
Sun Y, Fang R, Li C, Li L, Li F, Ye X, Chen H. Hsa-mir-182
suppresses lung tumorigenesis through down regulation of
RGS17 expression in vitro. Biochem Biophys Res Commun.
2010 May 28;396(2):501-7
Disease
hsa-mir-182 is involved in the down regulation of
RGS17 expression through two conserved sites located
in its 3' UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and
rs9479510) were found associated with familial lung
cancer susceptibility (You et al., 2009).
Atlas Genet Cytogenet Oncol Haematol. 2012; 16(3)
This article should be referenced as such:
Li C, Wang L, Sun Y, Chen H. RGS17 (regulator of G-protein
signaling 17). Atlas Genet Cytogenet Oncol Haematol. 2012;
16(3):216-217.
217