Download European Respiratory Society Annual Congress 2013

European Respiratory Society
Annual Congress 2013
Abstract Number: 4035
Publication Number: P3610
Abstract Group: 7.3. Cystic Fibrosis
Keyword 1: Cystic fibrosis Keyword 2: Physiology Keyword 3: Children
Title: Prospective follow up over 1 year with N2 multiple breath washout (MBW) in children with cystic
fibrosis
Dr. Anders 25237 Lindblad [email protected] MD 1, Dr. Monica 25238 Rosberg
[email protected] 2, Dr. Birgitta 25239 Houltz [email protected] MD 3 and Dr. Per
25240 Gustafsson [email protected] MD 4. 1 Dept of Pediatrcs, Queen Silvia Childrens Hospital,
Gothenburg, Sweden ; 2 Dept of Clinical Physiology, Sahlgrenska University Hospital/East, Gothenburg,
Sweden ; 3 Dept of Clinica Physiology, Queen Silvia Childrens Hospital, Gothenburg, Sweden and 4 Dept of
Pediatrics, Kärnsjukhuset, Skövde, Sweden .
Body: Background: The N2 MBW method is increasingly used in studies to assess ventilation
inhomogeneity. It is more sensitive than spirometry in detecting early changes of cystic fibrosis (CF) lung
disease. The aim was to evaluate the change and variation of lung clearance index (LCI) over a one-year
period in children with CF. Methods: Triplets of N2 MBW were recorded (Exhalyzer D, Eco Medics AG) in 25
CF subjects (15M) aged 6-18 yrs (median 10.2 yrs, mean FEV1.0 92 (17)% (1). Five had chronic P.
aeruginosa (PA) infection. The MBW test was done at the patients regular visits to the outpatient clinic. A
minimum of two acceptable washouts were required for inclusion. Results: 109 N2 MBW test occasions
were undertaken. In 108/109 occasions two or three technically acceptable MBW washouts were recorded,
while in 1/109 failed. There was no difference between LCIs at the first and the last N2 MBW test (9.58(2.73)
vs 9.60 (2.82)(ns). Patients with chronic PA had higher LCI compared to non-PA (11.96(4.15) vs 8.98(1.98);
p=0.026). Median number of tests during one year was 4/patient (range 2-6).The within test occasion CV for
LCI was 5.8 (3.5)%. The mean between test standard deviation of LCI for the washouts in each patient was
0.83 (0.46) (absolute units) with a greater variation in patients high LCI. The mean CV for LCI between test
was, however, 8.5 (4.2)% with no bias with greater LCI. Conclusion: In this cohort, LCI was stable over a
one-year period. In absolute units, variability of LCI was less in patients with relatively low LCIs at start,
while the relative variation over time was independent of the initial LCI. 1.Quanjer GLI-2012 Equations,
www.lungfunction.org.