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Appendix A Glossary List of acronyms BHI BioTeC CFU ESAB FC FS IbM IbMs INDISIM MOSIMBIO MSE MSZ NMTA PBC RBC SCT-UB SS Brain Heart Infusion Bioprocess Technology and Control group Colony Forming Unit Escola Superior d'Agricultura de Barcelona Flow Cytometer Forward Scattered light (ow cytometry) Individual-based Modelling Individual-based Models INDividual DIScrete SIMulation Modelling and Computer Simulation of Biological Systems group Mean sum of Squared Errors Multisizer Nelder-Mead Threshold Accepting Periodic Boundary Conditions Red Blood Cells Scientic-Technical Services of the Universitat de Barcelona Side Scattered light (ow cytometry) 174 Glossary SSE TIP TA UB UPC Sum of Squared Errors Thermodynamics of Irreversible Processes Threshold Accepting Universitat de Barcelona Universitat Politècnica de Catalunya List of abbreviations beg bib EN V EN V + exp inf max min ref s.u. sup X0 Xf beginning bibliography pre-inoculation environment present environment exponential phase inferior maximum minimum reference simulation units superior initial value of 'X' nal value of 'X' Glossary 175 List of symbols λ µ D(t) Dm (t) Dpk (t) m m(t) md mR N (t) pkm (t) tF D tG tR U lag parameter growth rate product distance mean mass distance mass distribution distance bacterial individual mass bacterial mean mass of a culture individual bacterial mass at division invidual mass to initiate reproduction cycle cell density instantaneous cell's biomass relative frequency time to the rst division generation time or doubling time reproduction cycle duration uptaken nutrient particles Chapter 1 α(t) τi b, c, Tmin , Tmax G(t) g1 , g2 kn M N G(t) Q(t) s s∗ smin tai tLAGi tmi adjustment function individual adjustment period parameters of Equation 1.4 growing fraction population mathematical attractors for dening lag parameter constant for Equation 1.9 cell biomass non-growing fraction population physiological excess biomass per cell total biomass per cell minimum biomass per cell individual adjustment period individual lag time individual generation time 176 Glossary Chapter 2 ρ σ (x, y) B b Bi cs d dmax Ds Exy Enz I Igen Js m1 , m2 nenz Nmon pmov tenz Venz Y Yenz Z1 , α, c, k , n parameter to x an interval of the growth curve standard deviation coordinates of a spatial cell increase in bacterial biomass parameter of Equation 2.2 vector that describes a bacterium concentration of substance s mean distance between neighbouring cells maximum movement radius diusion coecient of a substance vector that describes a spatial cell enzyme particles in a bacterial cell maintenance constant index to control the extracellular enzyme particles synthesis ux of a substance between neighbouring cells individual bacterial masses after division enzyme particles synthesized by a bacterial cell number of monomers contained in a polymer probability for a bacteria to move time duration of extracellular enzyme particles enzyme synthesis rate per unit of mass and time step metabolic eciency energy cost of enzyme synthesis parameters of the uptake model Chapter 3 Ek r T mean kinetic energy of the nutrient particles radius of the accessible volume of nutrient particles around a bacterium temperature Glossary 177 Chapter 4 ∆m λpseudo λreal µB µN ρ τ B , tB a B(t) mi p(mi ) PEXP PI(B) PI(N ) PT (B) PT (N ) R t 1 , t2 te , N e Z, γ, β biomass interval to dene the classes of biomass apparent lag or pseudolag of a culture real lag of a culture total biomass growth rate cell density growth rate parameter to x an interval of the growth curve parameters to distinguish the balanced growth parameter of Equation 4.10 total biomass of a culture class of biomass biomass probability distribution of a bacterial culture exponential phase initial phase in total biomass initial phase in cell density transition phase in total biomass transition phase in cell density mean of duplications per hour of an individual cell temporal limits of transition phase in cell density coordinates of an exponential point of the growth curve parameters of Equation 4.4 Chapter 5 d Dd (t) Dpkd (t) Dd (t) fs N pkm (t) R ss equivalent diameter mean diameter distance diameter distribution distance product distance forward scatter channels number of channels instantaneous cell's diameter relative frequency mean of duplications per hour of an individual cell side scatter channels 178 Glossary Chapter 6 Γ, α , β γ , ρ, χ, σ ξ ρ ρ̂ τr A, B , C Cexp (t) Csim (t) f (m; A, B) → F (− x) g m n npi nR nS,r pi p̂i → Q(− x) R1 , R2 , R 3 ts umax Vd → − x Y parameters to x the thresholds (NMTA) coecients of NMTA geometric operations random simplex shift probability (NMTA) radius of the trust region (NEWUOA) re-scaled radius of the trust region (NEWUOA) threshold value for round r (NMTA) parameters of a Weibull distribution experimentally measured cell concentration simulation output of cell concentration Weibull distribution objective function (NEWUOA) number of generations per hour number of interpolation points (NEWUOA) total number of data points number of points to be tested for each parameter (grid search) number of stepping rounds (NMTA) number of simplex steps in round r (NMTA) parameters to be estimated re-scaled parameters to be estimated (NEWUOA) quadratic model (NEWUOA) number of evaluations of the objective function at each simplex vertex (NMTA) time step mean maximum uptake rate bacterial volume at division vector with a combination of parameters to be estimated (NEWUOA) yield