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Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN In Vitro In Vivo Concentration Concentration Tested Tested Chemical Class Form Tested Triethanolamine Triton X-100 Acetone Ammonium nitrate L-Aspartic acid 102-71-6 9002-93-1 67-64-1 6484-52-2 70-47-3 10% 1% 100% 100% 100% 10% 1% 100% 100% 100% Amine, Alcohol Ether Ketone Inorganic salt, Onium Amino acid Solution Solution Liquid Solid Solid Benzalkonium chloride 8001-54-5 1% 1% Onium Solution Benzalkonium chloride Benzalkonium chloride Benzoyl-L-tartaric acid Butyl acetate gamma-Butyrolactone 8001-54-5 8001-54-5 2743-38-6 123-86-4 96-48-0 5% 10% 100% 100% 100% 5% 10% 100% 100% 100% Captan 90 concentrate 133-06-2 100% 100% 619-66-9 100% 100% 140-72-7 0.1% 0.1% 140-72-7 6% 6% 140-72-7 10% 10% 55-56-1 108-93-0 1623-08-1 100% 100% 100% 100% 100% 100% Onium Onium Carboxylic acid, Ester Ester Heterocycle, Lactone Imide, Organic sulfur compound Carboxylic acid, Aldehyde Heterocyclic compounds, Onium Heterocyclic compounds, Onium Heterocyclic compounds, Onium Amidine Alcohol Ester 4659-45-4 100% 100% 595-37-9 100% 100% 2,5-Dimethylhexanediol 110-03-2 100% 100% Ethanol Ethyl acetate 2-Ethyl-1-hexanol Ethyl-2methylacetoacetate Ethyl trimethyl acetate 64-17-5 141-78-6 104-76-7 100% 100% 100% 100% 100% 100% 609-14-3 100% 3938-95-2 100% Fomesafen 72128-02-0 100% 100% Glycerol n-Hexanol Imidazole Isobutanol Isopropanol 56-81-5 111-27-3 288-32-4 78-83-1 67-63-0 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 12427-38-2 100% 100% 79-20-9 105-34-0 96-37-7 78-93-3 108-10-1 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 86-87-3 100% 100% 4Carboxybenzaldehyde Cetylpyridinium bromide Cetylpyridinium bromide Cetylpyridinium bromide Chlorhexidine Cyclohexanol Dibenzyl phosphate 2,6-Dichlorobenzoyl chloride 2,2-Dimethylbutanoic acid Maneb Methyl acetate Methyl cyanoacetate Methylcyclopentane Methyl ethyl ketone Methyl isobutyl ketone 1-Naphthalene acetic acid 1-Naphthalene acetic acid, Na salt GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Solution Solution Solid Liquid Liquid Nonirritant Nonirritant Category 2A Category 2B SCNM Category 1/Category 2A Category 1 Category 1 Category 1 Nonirritant Category 2A Category IV Category III Category II Category III SCNM Nonirritant Nonirritant R36 R36 SCNM Solid Category 1 Solid Severe Severe 1 Category I R36/R41 Severe 2 4 2 Category I Category I SCNM Category III Category II R41 R41 R41 Nonirritant R36 Severe Severe 4 Category I Category 2A Solution Nonirritant Solution Category 1 Solution Severe Moderate Nonirritant Severe Nonirritant Reference Bagley et al. (1992) Bagley et al. (1992) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Nonirritant Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) R41 Nonirritant Balls et al. (1995) Category II R36 Moderate Balls et al. (1995) Category III Nonirritant Nonirritant Balls et al. (1995) 2 SCNM R41 Severe Balls et al. (1995) Category 1 4 Category I R41 Severe Solid Liquid Solid Category 1 Category 1 Category 2A 4 2 SCNM Category I Category II SCNM R41 R36 Severe Acyl halide Liquid Category 2A Category II SCNM Severe Carboxylic acid Liquid SCNM Category I SCNM Severe Alcohol Solid Category 1 Category I R41 Severe Alcohol Ester Alcohol Liquid Liquid Liquid Category 2A Nonirritant Category 2A Category III Category III Category II Nonirritant Nonirritant R36 Severe Severe Nonirritant Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) 100% Ketone, Ester Liquid Category 2B Category III Nonirritant Severe Balls et al. (1995) 100% Ester Imide, Ether, Nitro compound Alcohol Alcohol Heterocycle Alcohol Alcohol Amine, Organic salt, Urea Ester Ester, Nitrile Cyclic hydrocarbon Ketone Ketone Carboxylic acid, Polycyclic compound Organic salt, Carboxylic acid salt, Polycyclic compound Alcohol Amine Alcohol, Ether Inorganic salt Amine, Heterocycle, Organic sulfur compound Heterocycle Amine, Heterocycle, Polycyclic compound Alkali Alkali Organic salt, Carboxylic acid salt Organic salt, Carboxylic acid salt Liquid Nonirritant Category III Nonirritant Nonirritant Solid Nonirritant Category III Nonirritant Liquid Liquid Solid Liquid Liquid Nonirritant Category 2A Category 1 Category 2A Category 2A Category IV Category II Category I Category II Category III Nonirritant R36 R41 R36 SCNM 61-31-4 100% 100% 111-87-5 371-40-4 25322-68-3 590-28-3 100% 100% 100% 100% 100% 100% 100% 100% Promethazine HCl 58-33-3 100% 100% Pyridine 110-86-1 100% 100% Quinacrine 69-05-6 100% 100% Sodium hydroxide Sodium hydroxide 1310-73-2 1310-73-2 1% 10% 1% 10% Sodium lauryl sulfate 151-21-3 3% 3% Sodium lauryl sulfate 151-21-3 15% 15% n-Octanol Parafluoraniline Polyethylene glycol 400 Potassium cyanate pH March 2006 1 4 Moderate Severe Severe Nonirritant Balls et al. (1995) SCNM Nonirritant Category II Category II Category III Category III Category III R36 R36 Nonirritant R36 Nonirritant Severe Moderate Nonirritant Severe Moderate Solid Category 1 NC Category I SCNM 1 Category 1 Liquid Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Category III Solid Balls et al. (1995) Severe SCNM Category 1 Balls et al. (1995) Severe Balls et al. (1995) Category 2A Category 2A Nonirritant Category 2A Nonirritant Category 2A SCNM Nonirritant SCNM Balls et al. (1995) Nonirritant Severe Severe Severe Severe Solid Solid Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Moderate Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Solid Balls et al. (1995) Moderate Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Moderate Balls et al. (1995) Category I R41 Severe Severe Balls et al. (1995) Category II SCNM Category IV SCNM R36 SCNM Nonirritant SCNM Moderate Severe Nonirritant Severe Severe Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) 1 Category I R41 Severe Severe Balls et al. (1995) Category 1 4 Category I R41 Severe Solid Category 1 3 Category I R41 Solution Solution Category 2B Category 1 4 Category III Category I R36 R41 Severe Severe Balls et al. (1995) Balls et al. (1995) Solution Nonirritant Category III Nonirritant Severe Balls et al. (1995) Solution Category 1 Category I SCNM Severe Balls et al. (1995) NC D-5 Balls et al. (1995) Nonirritant Balls et al. (1995) Data By Reference HET-CAM BRD: Appendix D1 Substance Name Sodium oxalate CASRN In Vitro In Vivo Concentration Concentration Tested Tested 62-76-0 100% 100% Sodium perborate 10486-00-7 100% 100% Tetraaminopyrimidine sulfate 5392-28-9 100% 100% Thiourea 62-56-6 100% 100% Toluene Trichloroacetic acid Trichloroacetic acid 108-88-3 76-03-9 76-03-9 100% 3% 30% Triton X-100 9002-93-1 Triton X-100 Tween 20 Acetic acid Acetic acid Chemical Class Organic salt, Carboxylic acid salt Inorganic salt, Boron containing compound Amine, Heterocycle Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Reference Solid Category 1 4 Category I R41 Moderate Balls et al. (1995) Solid Category 1 4 Category I R41 Nonirritant Balls et al. (1995) Solid Nonirritant Category III Nonirritant Nonirritant Balls et al. (1995) Severe Balls et al. (1995) 100% 3% 30% Organic sulfur compound Polycyclic compound Carboxylic acid Carboxylic acid Liquid Solution Solution 5% 5% Ether Solution 9002-93-1 9005-64-5 64-19-7 64-19-7 10% 100% 100% 10% 10% 100% n.a. n.a. Ether Ester, Ether Carboxylic acid Carboxylic acid Solution Liquid Liquid Solution Benzalkonium chloride 8001-54-5 100% n.a. Onium Unknown Brij 35 9002-92-0 100% n.a. Alcohol Solid Butanol Butanol 71-36-3 71-36-3 100% 10% n.a. n.a. Dimethyl sulfoxide 67-68-5 100% n.a. Dimethyl sulfoxide 67-68-5 10% n.a. Glycerol Glycerol n-Hexane n-Hexane 2-Methoxyethanol 2-Methoxyethanol 56-81-5 56-81-5 110-54-3 110-54-3 109-86-4 109-86-4 100% 10% 100% 10% 100% 10% n.a. n.a. n.a. n.a. n.a. n.a. Sodium dodecyl sulfate 151-21-3 100% n.a. Sodium dodecyl sulfate 151-21-3 10% n.a. Toluene Triethanolamine Triethanolamine Triacetin Triacetin 108-88-3 102-71-6 102-71-6 102-76-1 102-76-1 100% 100% 10% 100% 10% n.a. n.a. n.a. n.a. n.a. Tributyltin chloride 1461-22-9 100% n.a. Tributyltin chloride 1461-22-9 10% n.a. 2-Butoxyethyl acetate 2-Butoxyethyl acetate Dibutyltin chloride Hydroalcoholic Formulation 1-5% Alcohol Containing Formulation (PROD00187) Hydroalcoholic Formulation 2-10% Alcohol Containing Formulation (PROD00183) Hydroalcoholic Formulation 3-15% Alcohol Containing Formulation (PROD00186) Hydroalcoholic Formulation 4-20% Alcohol Containing Formulation (PROD00185) 112-07-2 112-07-2 683-18-1 100% 10% 100% n.a. n.a. n.a. Alcohol Alcohol Organic sulfur compound Organic sulfur compound Alcohol Alcohol Acyclic hydrocarbon Acyclic hydrocarbon Alcohol Alcohol Organic salt, Carboxylic acid salt Organic salt, Carboxylic acid salt Polycyclic compound Amine, Alcohol Amine, Alcohol Ester Ester Organometallic compound Organometallic compound Ester Ester Organic salt Undiluted Undiluted Formulation Solution Nonirritant Undiluted Undiluted Formulation Solution Undiluted Undiluted Formulation Undiluted Undiluted Formulation Solid Nonirritant Nonirritant Nonirritant Category 1 Categorry 2A/Category 2B Category 1 Nonirritant 4 4 Category III Category III Category I Nonirritant Nonirritant R41 Severe Severe Severe Balls et al. (1995) Balls et al. (1995) Balls et al. (1995) Category III Nonirritant/R3 6 Severe Balls et al. (1995) Severe Nonirritant Category II Category III Cationic Surfactant Nonionic Surfactant SCNM Nonirritant R41 R41 Severe Severe Balls et al. (1995) Balls et al. (1995) CEC (1991) CEC (1991) R41 Severe CEC (1991) Nonirritant Slight CEC (1991) Liquid Solution R36 R36 Severe Severe CEC (1991) CEC (1991) Liquid Nonirritant Severe CEC (1991) Solution Nonirritant Slight CEC (1991) Liquid Solution Liquid Solution Liquid Solution Nonirritant Nonirritant Nonirritant Nonirritant Nonirritant Nonirritant Severe Slight Slight Severe Severe Moderate CEC (1991) CEC (1991) CEC (1991) CEC (1991) CEC (1991) CEC (1991) R41 Severe CEC (1991) R36 Severe CEC (1991) Liquid Liquid Solution Liquid Solution Nonirritant Nonirritant Nonirritant Nonirritant Nonirritant Severe Severe Slight Slight Slight CEC (1991) CEC (1991) CEC (1991) CEC (1991) CEC (1991) Solid Solution Anionic Surfactant Anionic Surfactant Solid R41 Moderate CEC (1991) Solution R41 Severe CEC (1991) Liquid Solution Solid Nonirritant Nonirritant R41 Slight Slight Severe CEC (1991) CEC (1991) CEC (1991) Category III Nonirritant Slight Gettings et al. (1991) Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) Solution Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) Solution Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) D-6 Data By Reference HET-CAM BRD: Appendix D1 Substance Name Hydroalcoholic Formulation 5-33% Alcohol Containing Formulation (PROD00184) Hydroalcoholic Formulation 6-40% Alcohol Containing Formulation (PROD00189) Hydroalcoholic Formulation 7-55% Alcohol Containing Formulation (PROD00188) Hydroalcoholic Formulation 8-65% Alcohol Containing Formulation (PROD00180) Hydroalcoholic Formulation 9-83% Alcohol Containing Formulation (PROD00181) Hydroalcoholic Formulation 10-90% Alcohol Containing Formulation (PROD00182) Oil/Water EmulsionHZA Oil/Water EmulsionHZC Oil/Water EmulsionHZE Oil/Water EmulsionHZF Oil/Water EmulsionHZH Oil/Water EmulsionHZI Oil/Water EmulsionHZJ Oil/Water EmulsionHZL Oil/Water EmulsionHZM Oil/Water EmulsionHZN Oil/Water EmulsionHZO Oil/Water EmulsionHZR Oil/Water EmulsionHZS Oil/Water EmulsionHZT Oil/Water EmulsionHZU Oil/Water EmulsionHZV Oil/Water EmulsionHZW Oil/Water EmulsionHZY Surfactant Based Formulation 1-HZA Surfactant Based Formulation 2-HZB Surfactant Based Formulation 3-HZC CASRN In Vitro In Vivo Concentration Concentration Tested Tested Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Undiluted Undiluted Formulation Solution Nonirritant Undiluted Undiluted Formulation Solution Category 1 Undiluted Undiluted Formulation Solution Category 1 Undiluted Undiluted Formulation Solution Undiluted Undiluted Formulation Undiluted Undiluted Undiluted Undiluted Reference Category III Nonirritant No Data Gettings et al. (1991) 1 Category I R41 Severe Gettings et al. (1991) 1 Category I R41 Severe Gettings et al. (1991) Category 2B Category II Nonirritant Severe Gettings et al. (1991) Solution Category 2A Category II SCNM Severe Gettings et al. (1991) Formulation Solution Category 1 Category I R41 Severe Gettings et al. (1991) Undiluted Formulation Solution Nonirritant Category III Nonirritant Nonirritant Slight Gettings et al. (1994) Undiluted Formulation Solution Nonirritant Category III Nonirritant Nonirritant Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Moderate Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Severe Severe Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Nonirritant Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Severe Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Moderate Severe Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Nonirritant Gettings et al. (1994) Undiluted Undiluted Formulation Solution Category 1 Category I R41 Severe Severe Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Severe Moderate Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Slight Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Nonirritant Nonirritant Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Nonirritant Moderate Gettings et al. (1994) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Severe Severe Gettings et al. (1994) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Slight Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Severe Gettings et al. (1996) 1 1 D-7 Data By Reference HET-CAM BRD: Appendix D1 Substance Name Surfactant Based Formulation 4-HZD Surfactant Based Formulation 5-HZE Surfactant Based Formulation 6-HZF Surfactant Based Formulation 7-HZG Surfactant Based Formulation 8-HZH Surfactant Based Formulation 9-HZI Surfactant Based Formulation 10-HZJ Surfactant Based Formulation 11-HZK Surfactant Based Formulation 12-HZL Surfactant Based Formulation 13-HZM Surfactant Based Formulation 14-HZN Surfactant Based Formulation 15-HZP Surfactant Based Formulation 16-HZQ Surfactant Based Formulation 17-HZR Surfactant Based Formulation 18-HZS Surfactant Based Formulation 19-HZT Surfactant Based Formulation 20-HZU Surfactant Based Formulation 21-HZV Surfactant Based Formulation 22-HZW Surfactant Based Formulation 23-HZX Surfactant Based Formulation 24-HZY Surfactant Based Formulation 25-HZZ 2-Methoxyethanol CASRN 109-86-4 In Vitro In Vivo Concentration Concentration Tested Tested Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Reference 10% Undiluted Formulation Solution Category 2B Category III Nonirritant Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution SCNM Category I SCNM Slight Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 Category I R41 Severe Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Slight Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 2B Category III R36 Slight Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Slight Gettings et al. (1996) 100% 100% Alcohol, Ether Liquid Nonirritant Severe Gilleron et al. (1996) Nonirritant Slight Gilleron et al. (1996) Nonirritant Severe Severe Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) 1 Nonionic Surfactant Triton X-155 9010-44-0 100% 100% Alcohol, Ether Liquid DL-Glutamic acid Triethanolamine Allyl alcohol 19285-83-7 102-71-6 107-18-6 100% 100% 100% 100% 100% 100% Solid Liquid Liquid Nonirritant Nonirritant R36 1-Nitropropane 108-03-2 100% 100% Liquid Nonirritant Slight Gilleron et al. (1996) Methyl isobutyl ketone 108-10-1 100% 100% Liquid Nonirritant Severe Gilleron et al. (1996) Cyclohexanone 108-94-1 100% 100% Liquid Nonirritant Severe Gilleron et al. (1996) 1,2,4-Trichloropropane Furan Hexane 2-Ethoxyethanol Pyridine Octanol Anthracene 95-63-6 110-00-9 110-54-3 110-80-5 110-86-1 111-87-5 120-12-7 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% Amino acid Amine, Alcohol Alcohol Acyclic hydrocarbon, Nitro compound Ketone Ketone, Cyclic hydrocarbon Cyclic hydrocarbon Heterocycle Acyclic hydrocarbon Alcohol Heterocycle Alcohol Polycyclic compound Liquid Liquid Liquid Liquid Liquid Liquid Solid Nonirritant Nonirritant Nonirritant Nonirritant R36 R36 Nonirritant Slight Moderate Slight Severe Severe Severe Nonirritant Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Benzethonium chloride 121-54-0 100% 100% Amine, Onium Solid R41 Severe Gilleron et al. (1996) Diacetone alcohol 2,4-Pentadione 123-42-2 123-54-6 100% 100% 100% 100% Liquid Liquid Nonirritant Nonirritant Severe Moderate Gilleron et al. (1996) Gilleron et al. (1996) Ethylacetoacetate 141-97-9 100% 100% Ketone Ketone Carboxylic acid, Ketone Nonirritant Severe Gilleron et al. (1996) Laurylsulfobetaine 14933-08-5 100% 100% Amine, Onium Unknown R36 Moderate Gilleron et al. (1996) 100% Ether, Organosilicon compound Liquid Nonirritant Slight Gilleron et al. (1996) 3Glycidopropyltrimethox ysilane 2530-83-8 100% Cationic Surfactant Liquid Zwitterioni c Surfactant D-8 Data By Reference HET-CAM BRD: Appendix D1 Substance Name 2,4-Dicholor-5sulfamolyl-benzoic acid Dibenzoyl-L-tartaric acid Imidazole Iminodibenzyl Tetraaminopyrimidine sulfate Magnesium carbonate Hexadecyltrimethylam monium bromide CASRN In Vitro In Vivo Concentration Concentration Tested Tested GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 100% 100% Solid Nonirritant Slight Gilleron et al. (1996) 100% 100% Carboxylic acid, Ester Solid R41 Slight Gilleron et al. (1996) 288-32-4 494-19-9 100% 100% 100% 100% Heterocycle Heterocycle Solid Solid R36 Nonirritant Severe Nonirritant Gilleron et al. (1996) Gilleron et al. (1996) 5392-28-9 100% 100% Amine, Heterocycle Solid Nonirritant Nonirritant Gilleron et al. (1996) 56378-72-4 100% 100% Alcohol Solid Nonirritant Slight Gilleron et al. (1996) R36 Severe Gilleron et al. (1996) Solid R41 Severe Gilleron et al. (1996) Solid R36 Severe Gilleron et al. (1996) Liquid Solid Liquid Nonirritant Nonirritant Nonirritant Severe Moderate Severe Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1996) Liquid Nonirritant Severe Gilleron et al. (1996) Solid R36 Moderate Gilleron et al. (1996) Solid Nonirritant Slight Gilleron et al. (1996) Solid 57-09-0 100% 100% 100% 100% 62-56-6 100% 100% Ethanol Dimethyl biguanidine Methanol 64-17-5 657-24-9 67-56-1 100% 100% 100% 100% 100% 100% Dimethyl sulfoxide 67-68-5 100% 100% Quinacrine 69-05-6 100% 100% Gluconolactone 90-80-2 100% 100% 92-43-3 100% 100% 94-13-3 100% 100% 96-18-4 96-48-0 100% 100% 9002-92-0 Organic salt, Onium Amine, Heterocycle, Organic sulfur compound Organic sulfur compound Alcohol Amidine Alcohol Organic sulfur compound Amine, Heterocycle, Polycyclic compound Carboxylic acid, Lactone, Carbohydrate Heterocycle Liquid Cationic Surfactant Nonirritant Nonirritant Gilleron et al. (1996) Solid Nonirritant Slight Gilleron et al. (1996) 100% 100% Carboxylic acid, Phenol Acyclic hydrocarbon Heterocycle, Lactone Liquid Liquid Nonirritant R36 Moderate Severe Gilleron et al. (1996) Gilleron et al. (1996) 100% 100% Alcohol Solid Nonirritant Slight Gilleron et al. (1996) 25105-12-9 100% 100% Nonirritant Nonirritant Gilleron et al. (1996) 302-95-4 100% 100% R36 Severe Gilleron et al. (1996) 7631-98-3 100% 100% Aminde, Amine Salt Solid Nonirritant Severe Gilleron et al. (1996) 95-55-6 100% 100% Amine, Phenol Solid Nonirritant Nonirritant Gilleron et al. (1996) 100% 100% Unknown Solid Nonirritant Nonirritant Gilleron et al. (1996) MYRJ 45 Amine, Carboxylic acid, Organic salt Alcohol, Carboxylic acid, Organic salt Solid Solid Nonionic Surfactant Anionic Surfactant Nonionic Surfactant 86-87-3 100% 100% 1-Naphthalene acetic acid, Na salt 61-31-4 100% 100% 595-37-9 100% 100% Carboxylic acid Liquid SCNM 110-03-2 100% 100% Alcohol Solid Category 1 4659-45-4 100% 100% Acyl halide Liquid 104-76-7 100% 100% 619-66-9 100% 100% 67-64-1 6484-52-2 100% 100% 100% 100% Alcohol Carboxylic acid, Aldehyde Ketone Inorganic salt, Onium Benzalkonium chloride 8001-54-5 100% 5% Onium Solution Benzalkonium chloride 8001-54-5 100% 10% Onium Solution Benzalkonium chloride 8001-54-5 100% 1% Onium Solution Benzoyl-L-tartaric acid Butyl acetate 2743-38-6 123-86-4 100% 100% 100% 100% Solid Liquid Captan 90 concentrate 133-06-2 100% 100% 140-72-7 100% 0.10% 140-72-7 100% 10% Carboxylic acid, Ester Ester Imide, Organic sulfur compound Heterocyclic compounds, Onium Heterocyclic compounds, Onium Cetylpyridinium bromide Cetylpyridinium bromide Carboxylic acid, Polycyclic compound Organic salt, Carboxylic acid salt, Polycyclic compound Nonionic Surfactant 1-Naphthalene acetic acid 2,2-Dimethylbutanoic acid 2,5-Dimethylhexanediol 2,6-Dichlorobenzoyl chloride 2-Ethyl-1-hexanol 4Carboxybenzaldehyde Acetone Ammonium nitrate Reference 2743-38-6 58-33-3 Deoxycholic acid, sodium salt N-Lauroylsarcosine, sodium salt 2-Aminophemol pH 2736-23-4 Thiourea EDTA dipotassium Form Tested Amide, Organic sulfur compound Promethazine HCl 1-Phenyl-3pyrazolidine Propyl-4hydroxybenzoate 1,2,3-Trichloropropane Gamma-butyrolactone Polyoxyethylene 23 lauryl ether Chemical Class March 2006 Solid Category 1 NC Category I SCNM Moderate Gilleron et al. (1997) Solid Category 1 1 Category I R41 Severe Gilleron et al. (1997) Category I SCNM Severe Gilleron et al. (1997) Category I R41 Severe Gilleron et al. (1997) Category 2A Category II SCNM Severe Gilleron et al. (1997) Liquid Category 2A Category II R36 Severe Gilleron et al. (1997) Solid Category 2A Category II R36 Slight Gilleron et al. (1997) Category II Category III R36 R36 Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Liquid Solid Category 2A Category 2B Cationic Category Surfactant 1/Category 2A Cationic Category 1 Surfactant 2 Category I R36/R41 Severe Gilleron et al. (1997) 4 Category I R41 Severe Gilleron et al. (1997) Cationic Surfactant Category 1 1 Category I R41 Severe Gilleron et al. (1997) Category 1 Nonirritant 2 SCNM Category III R41 Nonirritant Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Category 1 4 Solid Solution Solution 1 Cationic Surfactant Cationic Surfactant Nonirritant Category 1 4 D-9 Category I R41 Severe Gilleron et al. (1997) Category III Nonirritant Severe Gilleron et al. (1997) SCNM R41 Severe Gilleron et al. (1997) Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN In Vitro In Vivo Concentration Concentration Tested Tested Cetylpyridinium bromide Chlorhexidine Cyclohexanol Dibenzyl phosphate Ethanol Ethyl acetate Ethyl trimethyl acetate Ethyl-2methylacetoacetate 140-72-7 100% 6% 55-56-1 108-93-0 1623-08-1 64-17-5 141-78-6 3938-95-2 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 609-14-3 100% 100% Fomesafen 72128-02-0 100% 100% 96-48-0 56-81-5 111-27-3 288-32-4 78-83-1 67-63-0 70-47-3 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% Chemical Class Heterocyclic compounds, Onium Amidine Alcohol Ester Alcohol Ester Ester Ketone, Ester 12427-38-2 100% 100% Methyl acetate Methyl cyanoacetate Methyl ethyl ketone Methyl isobutyl ketone Methylcyclopentane Octanol Parafluoraniline 79-20-9 105-34-0 78-93-3 108-10-1 96-37-7 111-87-5 371-40-4 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% Imide, Ether, Nitro compound Heterocycle, Lactone Alcohol Alcohol Heterocycle Alcohol Alcohol Amino acid Amine, Organic salt, Urea Ester Ester, Nitrile Ketone Ketone Cyclic hydrocarbon Alcohol Amine Polyethylene glycol 400 Gamma-butyrolactone Glycerol Hexanol Imidazole Isobutanol Isopropanol L-Aspartic acid Maneb Form Tested Solution pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Cationic Surfactant Reference Category 1 2 Category I R41 Severe Gilleron et al. (1997) Solid Liquid Solid Liquid Liquid Liquid Category 1 Category 1 Category 2A Category 2A Nonirritant Nonirritant 4 2 SCNM Category I Category II Category III Category III Category III SCNM R41 R36 Nonirritant Nonirritant Nonirritant Severe Severe Severe Severe Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Liquid Category 2B Category III Nonirritant Severe Gilleron et al. (1997) Solid Nonirritant Category III Nonirritant Slight Gilleron et al. (1997) Liquid Liquid Liquid Solid Liquid Liquid Solid Category 2A Nonirritant Category 2A Category 1 Category 2A Category 2A SCNM Category II Category IV Category II Category I Category II Category III SCNM R36 Nonirritant R36 R41 R36 SCNM SCNM Severe Severe Severe Severe Severe Severe Slight Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) 4 Solid SCNM Category III SCNM Nonirritant Gilleron et al. (1997) Liquid Liquid Liquid Liquid Liquid Liquid Liquid Category 2A Category 2A Category 2A Nonirritant Nonirritant Category 2A SCNM Category II Category II Category III Category III Category III Category II SCNM R36 R36 R36 Nonirritant Nonirritant R36 SCNM Severe Severe Severe Severe Severe Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Nonionic Surfactant 25322-68-3 100% 100% Alcohol, Ether Liquid Nonirritant Category IV Nonirritant Severe Gilleron et al. (1997) Potassium cyanate 590-28-3 100% 100% Solid SCNM SCNM SCNM Severe Gilleron et al. (1997) Promethazine HCl 58-33-3 100% 100% Solid Category 1 1 Category I R41 Moderate Gilleron et al. (1997) Pyridine 110-86-1 100% 100% Liquid Category 1 4 Category I R41 Severe Gilleron et al. (1997) Quinacrine 69-05-6 100% 100% Solid Category 1 3 Category I R41 Moderate Gilleron et al. (1997) Sodium hydroxide Sodium hydroxide 1310-73-2 1310-73-2 100% 100% 1% 10% Solution Solution Category 2B Category 1 4 Category III Category I R36 R41 Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Sodium lauryl sulfate 151-21-3 100% 3% Category III Nonirritant Severe Gilleron et al. (1997) Sodium lauryl sulfate 151-21-3 100% 15% Sodium oxalate 62-76-0 100% 100% Sodium perborate 10486-00-7 100% 100% Inorganic salt Amine, Heterocycle, Organic sulfur compound Heterocycle Amine, Heterocycle, Polycyclic compound Alkali Alkali Organic salt, Carboxylic acid salt Organic salt, Carboxylic acid salt Organic salt, Carboxylic acid salt Inorganic salt, Boron containing compound Tetraaminopyrimidine sulfate 5392-28-9 100% 100% Thiourea 62-56-6 100% 100% Toluene Trichloroacetic acid Trichloroacetic acid 108-88-3 76-03-9 76-03-9 100% 100% 100% Triton X-100 9002-93-1 Triton X-100 Tween 20 Amine, Heterocycle Solution Solution Anionic Surfactant Anionic Surfactant Nonirritant Category 1 NC Category I SCNM Severe Gilleron et al. (1997) Solid Category 1 4 Category I R41 Severe Gilleron et al. (1997) Solid Category 1 4 Category I R41 Severe Gilleron et al. (1997) Solid Nonirritant Category III Nonirritant Slight Gilleron et al. (1997) Severe Gilleron et al. (1997) 100% 30% 3% Organic sulfur compound Polycyclic compound Carboxylic acid Carboxylic acid Liquid Liquid Liquid Undiluted 5% Ether Liquid 9002-93-1 Undiluted 10% Ether Liquid 9005-64-5 100% 100% Ester, Ether Liquid Acetic acid 64-19-7 10% 10% Carboxylic acid Solution Category 1 Butanol 71-36-3 10% 10% Alcohol Solution Cetyltrimethylammoniu m bromide 57-09-0 10% 10% Organic salt, Onium 18472-51-0 10% 10% Amidine, Ester Chlorhexidine gluconate Solution (20% Solution) Solid Category III Category III Category I Nonirritant Nonirritant R41 Severe Severe Severe Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Category III Nonirritant/R3 6 Severe Gilleron et al. (1997) Category II SCNM Severe Gilleron et al. (1997) Category III Nonirritant Severe Gilleron et al. (1997) 4 Category I R41 Severe Category 1 4 SCNM R41 Severe Solution Category 1 4 Category I R41 Severe Solution Category 2B Category II Nonirritant Severe Nonionic Surfactant Nonionic Surfactant Nonionic Surfactant Nonirritant Nonirritant Category 1 Categorry 2A/Category 2B Category 1 4 4 Nonirritant D-10 Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN In Vitro In Vivo Concentration Concentration Tested Tested Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Di(2-ethylhexyl) sodium sulfosuccinate 577-11-7 10% 10% Organic salt, Sulfur containing compound, Ester Diisopropanolamine 110-97-4 10% 10% Amine, Alcohol Solution Nonirritant Domiphen bromide 538-71-6 10% 10% Organic salt, Onium, Ether Solution Category 1 Ethanol 64-17-5 10% 10% Alcohol Solution Ethanol 64-17-5 100% 100% Alcohol Glycolic acid 79-14-1 10% 10% Reference Lactic acid 50-21-5 10% 10% Carboxylic acid, Alcohol Lactic acid 50-21-5 100% 100% Carboxylic acid, Alcohol Liquid Category 1 4 Category I R41 Severe Potassium laurate 10124-65-9 10% 10% Organic salt, Carboxylic acid salt Solution Category 1 4 Category I R41 Severe Stearyltrimethylammon ium chloride 15461-40-2 10% 10% Organic salt, Onium Solution Category 1 4 Category I R41 Severe Triethanolamine 102-71-6 10% 10% Amine, Alcohol Solution Nonirritant Category IV Nonirritant Slight Triethanolamine 102-71-6 100% 100% Amine, Alcohol Liquid Nonirritant Category III Nonirritant Moderate Monoethanolamine 141-43-5 10% 10% Amine, Alcohol Solution Category 2B Category III Nonirritant Severe Ethanol 64-17-5 10% Unknown Nonirritant Category IV Nonirritant Slight 10124-65-9 10% Unknown Category 1 4 Category I R41 Severe Kojima et al. (1995) 151-21-3 10% Alcohol Organic salt, Carboxylic acid salt Organic salt, Carboxylic acid salt Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Hagino et al. (1999)/Submitted Y. Ohno Data Hagino et al. (1999)/Submitted Y. Ohno Data Kojima et al. (1995) Unknown Category 1/Category 2A 4 Moderate Kojima et al. (1995) 15461-40-2 10% Organic salt, Onium Unknown Category 1 4 Kojima et al. (1995) 9002-93-1 10% 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC Ether Unknown Category 1 Alcohol, Ether Unknown Alcohol, Ether Unknown 9 SCNM Alcohol, Ether Unknown ns Nonirritant Aldehyde, Ester Unknown ns Category 1 1 Category I Inorganic salt Solid 11.4 Category 1 4 SCNM Inorganic salt Solid 1.1 Category 1 4 SCNM Amide, Amino acid Solid 2.2 Category 1 4 Amine, Heterocycle, Alcohol Solid 9 Nonirritant 100%, 10%, and ITC Amine, Ether, Organic sulfur compound Unknown 1.5 Category 1 Inorganic salt Solid 1.5 Ether Liquid ns Unknown Unknown Aldehyde Liquid Potassium laurate Sodium lauryl sulfate Stearyltrimethylammon ium chloride Triton X-100 C12/C14-Glucoside Isodecylglucoside Nitro-bis-octylamide 7-Acetoxyheptanal Sodium disilicate 13870-28-5 Sodium hydrogen sulfate 7681-38-1 n-Acetyl-Methionine 1115-47-5 Ambuphylline 5634-34-4 4-Amino-5-methoxy-2methylbenzenesulfonic acid 6471-78-9 Ammoniumpersulfate 7727-54-0 Anisole 100-66-3 B 25 n-Butanal 123-72-8 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC Solution Category 1 4 Category I R36 Severe Category III Nonirritant Moderate Category I R41 Severe Nonirritant Category IV Nonirritant Slight Liquid SCNM SCNM SCNM Severe Carboxylic acid, Alcohol Solution Category 2B Category III Nonirritant Severe Solution SCNM Category III SCNM Severe 4 Category R41/Nonirritan I/Category II t Category I R41 Severe Category II SCNM Moderate Category I R41 Severe SCNM SCNM Severe Severe Category III Nonirritant Slight Moderate R41 Slight Severe SCNM Severe Severe SCNM Severe Severe SCNM R41 Severe Severe Category IV Nonirritant Severe Severe SCNM SCNM Moderate Severe SCNM SCNM SCNM Slight Severe SCNM SCNM SCNM Moderate Severe ns Nonirritant Category IV Nonirritant Nonirritant Nonirritant <7 Category 2B Category III Nonirritant Moderate Severe 9 Category 1 1 4 D-11 Severe Kojima et al. (1995) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN n-Butanol 71-36-3 Butyl carbamate 592-35-8 Caffeine sodium benzoate Caffeine sodium salicylate Camphen Cerium-2ethylhexanoate 8000-95-1 8002-85-5 79-92-5 24593-34-8 1-Chloroctane-8-ol 3-Cyclohexene-1methanol 1679-51-2 DC 8 1,4-Dibutoxy-benzene 104-36-9 Diepoxid 126 2386-87-0 2,5-Dimethylhexanediol 110-03-2 3,6-Dimethyloctanol 4,4-Dimethyl-3-oxopentanenitrile 1-(2,6dimethylphenoxy)-2propanone 59997-51-2 53012-41-2 Diphocars 1,2-Dodecanediol DTPA Pentasodium salt 1119-87-5 140-01-2 Ede 140 1,2-Epoxycyclooctane 286-62-4 1,2-Epoxydodecane 2855-19-8 Ethiosan In Vitro In Vivo Concentration Concentration Tested Tested 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC Ethyl butanal 97-96-1 Genomoll 115-96-8 100%, 10%, and ITC L-Glutamic acid hydrochloride 138-15-8 100%, 10%, and ITC Glycediol Granuform Hexahydrofarnesylaceto ne Hexamethylenetetramin e 1,2,6-Hexanetriol Hnol Hoe MBF Hydo 98 30525-89-4 502-69-2 100-97-0 106-69-4 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Alcohol Liquid ns Category 1 SCNM SCNM Severe Severe Ester Solid ns SCNM SCNM SCNM Severe Severe Solid 7 Nonirritant Category IV Nonirritant Moderate Severe Solid 7 Nonirritant Category IV Nonirritant Severe Severe Cyclic hydrocarbon Solid 7 Category 2B Category III R36 Severe Slight Organic salt, Carboxylic acid salt Unknown 3 Nonirritant Category III Nonirritant Moderate Severe Alcohol Unknown ns Category 1 Category I R41 Moderate Severe Alcohol Unknown ns SCNM SCNM SCNM Severe Severe Unknown Unknown ns Nonirritant Category IV Nonirritant Nonirritant Moderate Heterocycle, Organic salt, Carboxylic acid salt Heteroycle, Phenol, Organic salt 4 1 Ether Unknown 7 Category 2B Category III R36 Slight Nonirritant Heterocycle, Ester, Ether Liquid ns SCNM SCNM SCNM Moderate Severe Alcohol Solid ns Category 1 1 Category I R36 Severe Severe Alcohol Unknown 7 Category 1 1 Category I R41 Nonirritant Slight Ketone, Nitrile Solid ns Nonirritant Category IV Nonirritant Moderate Moderate Alcohol, Ether Liquid 5 Nonirritant Category IV Nonirritant Severe Severe Unknown Unknown ns Category 1 Category I R41 Severe Severe 4 Alcohol Solid ns SCNM SCNM SCNM Slight Slight Organic salt, Carboxylic acid salt, Amino acid Unknown 11.5 SCNM SCNM SCNM Severe Severe Unknown Unknown ns Nonirritant Category IV Nonirritant Slight Slight Ether Solid 4.5 Nonirritant Category III Nonirritant Severe Moderate Moderate Reference Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Ether Solid ns SCNM SCNM SCNM Slight Unknown Unknown 8.5 SCNM Category III SCNM Slight - Aldehyde Liquid <7 SCNM SCNM SCNM Nonirritant Severe Solid 6 Nonirritant Category IV Nonirritant Severe Severe Spielmann et al. (1996) Unknown 0.9 SCNM SCNM SCNM Severe Severe Spielmann et al. (1996) Ether Unknown ns Nonirritant Category IV Nonirritant Slight Slight Ether Solid 4 Category 1 SCNM SCNM Slight Nonirritant Ketone Unknown ns Nonirritant Category III Nonirritant Slight Moderate Amine Solid 8.5 Nonirritant Category IV Nonirritant Moderate Severe Alcohol Solid 4.5 Nonirritant Category IV Nonirritant Severe Severe Unknown Unknown ns Nonirritant Category IV Nonirritant Nonirritant Moderate Unknown Unknown 4.3 Nonirritant Category III Nonirritant Nonirritant Nonirritant Unknown Unknown 6.5 Category 1 Category I R41 Severe Severe Ester, Organophophorous compound Organic salt, Carboxylic acid salt, Amino acid 4 1 D-12 Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Data By Reference HET-CAM BRD: Appendix D1 Substance Name 2Hydroxyethyliminodiso diumacetate 2-Hydroxyisobutyric acid In Vitro In Vivo Concentration Concentration Tested Tested Chemical Class Form Tested pH 135-37-5 100%, 10%, and ITC Amine, Alcohol, Organic salt Unknown 10.6 Nonirritant 594-61-6 Hypo 36 Hypo 45 Hypo 54 Hyton Iminodiacetic acid 142-73-4 Isobornyl acetate 125-12-2 Isobutanal Isononylaldehyde 78-84-2 35127-50-5 alpha-Ketoglutaric acid 328-50-7 Lactic acid 79-33-4 alpha-Lactid 4511-42-6 L-Lysine Monohydrate 39665-12-8 Mecre 3-Mercapto-1,2,4triazole 3179-31-5 mMethoxybenzaldehyde 591-31-1 Methyl acetate 79-20-9 Methylpentynol 77-75-8 N-(2-methylphenyl)Imidodi-carbonimidic diamide 93-69-6 2-Methyl-1-propanol 78-83-1 Methyltriglycol 112-35-6 Methyltriglycol 112-35-6 Napt Olak Ölesulf Phenylephrine hydrochloride 61-76-7 Phenylthiourea 103-85-5 Phosphonat A Piperazine 18833-13-1 PO 2 Polyethylene glycol butyl ether Polyethylene glycol dimethyl ether Polyethylene glycol GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 CASRN Hypo 20 9004-77-7 24991-55-7 25322-68-3 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC March 2006 Category IV Nonirritant Severe Severe Carboxylic acid Solid 1 Category 1 SCNM R41 Severe Severe Unknown Unknown 6.5 Nonirritant Category IV Nonirritant Moderate Moderate Unknown Unknown 7 Nonirritant Category IV Nonirritant Severe Severe Unknown Unknown 7 Nonirritant Category IV Nonirritant Slight Severe Unknown Unknown 6.5 SCNM SCNM SCNM Slight Slight Unknown Unknown 8.5 SCNM SCNM SCNM Severe Severe Amine, Carboxylic acid Solid 2.3 SCNM SCNM SCNM Severe Severe Ester Solid ns Nonirritant Category IV Nonirritant Slight Moderate Aldehyde Liquid <7 Category 2B Category III Nonirritant Slight Severe Aldehyde Liquid <7 Nonirritant Category III Nonirritant Nonirritant Severe Carboxylic acid Solid 1.75 Category 1 SCNM R41 Severe Severe Carboxylic acid, Alcohol Unknown 2 SCNM SCNM SCNM Severe Severe Heterocycle, Lactone Solid 3 SCNM Category III SCNM Severe Slight Amino acid Solid 10 SCNM Category III SCNM Severe Severe 4 4 Unknown Unknown 7 Nonirritant Category IV Nonirritant Severe - Heterocycle, Organic sulfur compound, Alcohol Solid 4 SCNM SCNM SCNM Severe - Aldehyde, Ether Solid ns Nonirritant Category IV Nonirritant Slight Severe Ester Liquid 7 Category 2B Category III R36 Slight Severe Alcohol Liquid ns Category 1 4 Category I R41 Severe Severe Amidine Solid 11.5 Category 1 4 SCNM SCNM Severe Slight Alcohol Liquid 3 Category 1 1 Category I R41 Severe Severe Alcohol, Ether Liquid 7 Nonirritant Category III Nonirritant Severe Severe Alcohol, Ether Liquid 7 Nonirritant Category III Nonirritant Severe Severe Unknown Unknown ns Nonirritant Category IV Nonirritant Slight Severe Unknown Unknown 8.3 Category 1 1 Category I R41 Severe Severe Unknown Unknown 8 Category 1 1 Category I R41 Severe Severe Solid 7 Nonirritant Category IV Nonirritant Severe Severe Solid 5.5 Nonirritant Category IV Nonirritant Slight Slight Unknown 2.1 Nonirritant Category III Nonirritant Moderate Severe Phenol, Alcohol, Organic salt Organic sulfur compound, Urea Unknown Heterocycle Solid 5 Nonirritant Category IV Nonirritant Severe Severe Unknown Unknown ns Nonirritant Category IV Nonirritant Slight Nonirritant Ether Liquid 6 SCNM SCNM SCNM Severe Severe Ether Unknown 7 Nonirritant Category IV Nonirritant Slight Severe Alcohol, Ether Unknown ns SCNM SCNM SCNM Slight Moderate D-13 Reference Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN Polysolvan 7397-62-8 Potassium cyanate 590-28-3 Potassium hexacyanoferrate II Potassium hexacyanoferrate III Gadopentetic acid dimeglumine salt 14459-95-1 13756-66-2 86050-77-3 RK Blau Rubinrot Y Sacyclo Sept Silan 103 1067-25-0 Silan 108 3069-40-7 Silan 165 29055-11-6 Silan 167 41453-78-5 Silan 253 18784-74-2 Sodium bisulfite 7631-90-5 Sodium sulfite 7757-83-7 Sodium cyanate 917-61-3 Polyhexamethylene guanidine 2-Pseudojonon Sodium lauryl ether sulfate Sodium monochloroacetate Sodiumpyrosulfite 4-((2sulfatoethyl)sulfonyl)aniline 3088-31-1 3926-62-3 7681-57-4 2494-89-5 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC TA 01946 Alkylsilan Theophylline sodium acetate In Vitro In Vivo Concentration Concentration Tested Tested 8002-89-9 100%, 10%, and ITC Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Alcohol, Ester Liquid 7 SCNM SCNM SCNM Severe Severe Inorganic salt Solid 10 SCNM SCNM SCNM Severe Severe Carboxylic acid Solid 9.5 SCNM SCNM SCNM Severe Severe Carboxylic acid Solid 8 SCNM SCNM SCNM Moderate Moderate Amine, Carboxylic acid, Organic salt Unknown ns SCNM SCNM SCNM Severe Moderate Unknown Unknown 2.6 Nonirritant Category IV Nonirritant Slight - Unknown Unknown SCNM Category IV SCNM Slight Moderate Unknown Unknown ns Nonirritant Category IV Nonirritant Slight Slight Unknown Organosilicon compound Organosilicon compound Organosilicon compound Unknown 3 Category 1 Category I R41 Severe Severe Liquid ns SCNM SCNM SCNM Slight Severe Liquid ns Nonirritant Category III Nonirritant Moderate Severe Unknown ns Nonirritant Category IV Nonirritant Nonirritant Moderate Unknown ns SCNM SCNM SCNM Slight Slight Organosilicon compound, Organic sulfur compound Organosilicon compound Inorganic acid, Inorganic salt 1 Unknown <7 SCNM SCNM SCNM Severe Severe Solid 4.5 Nonirritant Category III Nonirritant Severe Severe Inorganic salt Solid 10 SCNM Category III SCNM Severe Severe Inorganic salt Solid 10 SCNM Category III SCNM Severe Severe Amidine Unknown 7.1 Category 1 Category I R41 Severe Severe Unknown Unknown ns Category 2B Category III Nonirritant Moderate Moderate Organic salt, Ester, Ether Organic salt, Carboxylic acid salt 4 Reference Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Unknown 8 SCNM SCNM SCNM Severe Severe Solid 4.5 Category 2B Category III R36 Moderate Severe Inorganic salt Solid 4.6 SCNM SCNM SCNM Severe Severe Amine, Organic sulfur compound, Ether Unknown 7 Category 1 SCNM R41 Severe Severe Spielmann et al. (1996) Unknown Unknown ns Nonirritant Category IV Nonirritant Severe Severe Heterocycle, Organic salt, Carboxylic acid salt Spielmann et al. (1996) Unknown 11 Nonirritant Category IV Nonirritant Severe Moderate Spielmann et al. (1996) 4 D-14 Data By Reference HET-CAM BRD: Appendix D1 Substance Name CASRN Tocla Triisooctylamine 25549-16-0 2,2,3-Trimethyl-3Cyclopentene-1acetaldehyde 4501-58-0 Trioxane 110-88-3 Wessalith Slurry In Vitro In Vivo Concentration Concentration Tested Tested 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC 100%, 10%, and ITC Xanthinol nicotinate 437-74-1 Sodium lauryl sulfate 151-21-3 1% 1% Tween 20 9005-64-5 100% 100% Chemical Class Form Tested pH March 2006 GHS In Vitro In Vitro In Vitro In Vitro In Vitro 11n Vitro Property In Vivo (GHS) Category 1 In Vivo (EPA) In Vivo (EU) Classification Classification Classification Classification Classification Classification of Interest Classification2 Classification4 Classification5 Subclass3 (IS(A))6 (IS(B))7 (IS(B)-10)8 (IS(B)-100)9 (Q-Score)10 (S-Score)11 Unknown Unknown 6 Category 1 Category I R41 Severe Severe Amine Solid 7 Nonirritant Category IV Nonirritant Nonirritant Severe SCNM SCNM Slight Severe Category III Nonirritant Severe Severe 1 Aldehyde Solid 2.3 SCNM Heterocycle, Ether Solid ns Nonirritant Unknown Unknown 11 Category 2A Category II Nonirritant Severe Severe Solid 6 Nonirritant Category IV Nonirritant Severe Severe Nonirritant Category IV Nonirritant Severe Nonirritant Category III Nonirritant Slight Amine, Heterocycle, Alcohol Organic salt, Carboxylic acid salt Ester, Ether Solution Liquid Anionic Surfactant Nonionic Surfactant Reference Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Spielmann et al. (1996) Vinardell and Macián (1994) Vinardell and Macián (1994) Abbreviations: CASRN = Chemical Abstract Service Registry Number, EPA = United States Environmental Protection Agency, EU = European Union, GHS = Globally Harmonized System, ITC = irritatation threshold concentration, n.a. = not applicable, SCNM = study criteria not met. 2 Eye Irritant Category 1 = irreversible effects on the eye/serious damage to the eye; Category 2A = reversible effects on the eye/irritating to the eyes; Category 2B = reversible effects on the eye/mildly irritating to the eyes; Nonirritant = not an eye irritant 3 NICEATM-defined subgroups assigned based on the lesions that drove classification of a GHS Category 1 substance. 1: based on lesions that are persistent; 2: based on lesions that are severe (not including corneal opacity score equal to 4); 3: based on lesions that are severe (not including corneal opacity score equal to 4) and persistent; 4: corneal opacity score equal to 4 at any time; NC: No subclassification could be made based on the data. 4 Toxicity Category I for the Primary Eye Irritation Study = Corrosive, or corneal involvement or irritation not reversible within 21 days; Category II = Corneal involvement or irritation clearing in 8-21 days; Category III = Corneal involvement or irritation clearing in 7 days or less; Category IV = Minimal effects clearing within 24 hr. 5 Risk phrase R41 = risk of serious damage to the eyes; R36 = irritating to the eyes; nonirritant = not an eye irritant. 6 IS(A) represents irritation scores that were calculated using the method described in Leupke (1985) 7 IS(B) represents irritation scores that were calculated using a method similar to the one described in Kalweit et al. (1987, 1990) 8 IS(B)-10 represents irritation scores that were calculated using the method described in Luepke (1985) when substances were tested at a 10% concentration in Spielmann et al. (1996) 9 IS(B)-100 represents irritation scores that were calculated using the method described in Luepke (1985) when substances were tested at a 100% concentration in Spielmann et al. (1996) 10 Q-Score represents irritation scores that were calculated using the method described in Balls et al. (1995) 11 S-Score represents irritation scores that were calculated using the method described in Balls et al. (1995) D-15
