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Download Stem cells in skeletal muscle regeneration.
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NUS Graduate School for Integrative Sciences and Engineering Research Project Write-up Title of Project : Name of Supervisor : Contact Details: Stem cells and skeletal muscle regeneration. Reshma Taneja Tel: 65163236 e-mail: [email protected] Short Description Muscle regeneration is a feature of postnatal muscle, and occurs to replace damaged muscles following exercise or injury. Satellite cells, the local skeletal muscle stem cells, are primarily responsible for regeneration. Quiescent satellite cells are activated upon muscle damage, and re-enter the cell cycle providing a large pool of proliferating myoblasts, which differentiate and fuse to form new myofibers, leading to regeneration of damaged muscles. In myopathies such as Duchene Muscular Dystrophy (DMD), the regeneration process is compromised, and muscle tissue is replaced by dysfunctional scar (fibrotic) tissue. The identification and characterization of genes involved in muscle regeneration is thus critical for developing treatment modalities for muscle injury and diseases. We have demonstrated that mice lacking the transcription factor Stra13 exhibit an inability to regenerate skeletal muscles in response to injury, and exhibit a dystrophy like pathology. Using Stra13-/- mice, the molecular mechanisms and signaling pathways through which Stra13 regulates muscle regeneration are being investigated.
