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Laboratory Learning Program Research Opportunity Research Opportunity Number: MOL-20 Project Title: Quorum sensing control of biofilm formation Project Summary: Biofilms are ubiquitous surface-attached bacterial communities embedded in an extracellular matrix. Biofilms can cause major problems: in medicine, biofilms are inherently resistant to antibiotics and cause chronic infections; in industry, biofilms foul surfaces of pipes and clog filtration devices. Studies aimed at mitigation are challenging because biofilms are heterogeneous and rearrange over time. A major challenge facing the biofilm field is the lack of microscopy and analytical tools capable of tracking the 3D arrangement of cells throughout biofilm development. In this project, the student will work with the model biofilm forming bacteria Vibrio harveyi. The goals are to use microscopy to resolve and analyze living biofilms at the single cell level, define the biophysical principles that underlie cell-cell ordering in biofilms, and explore cell-cell heterogeneity in living biofilms. Student Roles and Responsibilities: Student will work together with a senior graduate student and postdoc on a daily basis. Additional Considerations: Start and end dates are flexible, but the student should be available essentially full-time (at least 35 hours/week) for a minimum of 7 weeks. Department/Institute: Molecular Biology Faculty Sponsor: Bonnie Bassler Participation Dates: June to August, 2016 Stipend Offered: $300/week Number of Internships Available: 0-1 Application Deadline: March 15, 2016, midnight eastern daylight time