Download CURRICULUM VITAE - Vision Research Center

CURRICULUM VITAE
January 8, 2013
NAME:
YING, Gui-shuang
HOME ADDRESS:
1523 Brookhaven Road
Wynnewood, PA 19096
OFFICE ADDRESS:
3535 Market Street, Suite 700
Philadelphia, Pennsylvania 19104-3309
Email: [email protected]
TELEPHONE:
(610) 645-0836 -Home
(215) 615-1514 -Work
PLACE OF BIRTH:
Zhejiang, P. R. China
Visa Status/Citizenship
Permanent Resident of United States / P. R. China
EDUCATION:
1988-1993
M.D., Zhejiang Medical University (Preventive Medicine)
1993-1996
M.P.H., Zhejiang Medical University (Toxicology)
1998-2000
M.S., University of Michigan School of Public Health (Biostatistics)
2000-2004
Ph.D., University of Pennsylvania School of Medicine (Biostatistics)
ACADEMIC APPOINTMENTS:
2004-
Assistant Professor (Clinician-Educator Track, 10-Years Appointment),
Department of Ophthalmology, Scheie Eye Institute,
University of Pennsylvania School of Medicine
2004-
Director, Biostatistics Consulting Service,
Center for Preventive Ophthalmology and Biostatistics,
Department of Ophthalmology,
University of Pennsylvania School of Medicine
2005-
Associate Scholar, Biostatistics Unit
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
2005-
Faculty Member, Graduate Group in Epidemiology & Biostatistics
Biomedical Graduate Studies Program
University of Pennsylvania School of Medicine
HONORS AND AWARDS:
1
1989-1993
Scholarship from Zhejiang Medical University
1993
Best Bachelor Thesis Award from Zhejiang Medical University
1993
Outstanding Graduate Award from Zhejiang Medical University
1994-1995
Graduate Fellowship from Graduate School of Zhejiang Medical University
2007
McCabe Pilot Award to research proposal “Optimal prediction of patient accrual, trial
length and cost in randomized clinical trials”, University of Pennsylvania
2008
The ARVO Foundation for Eye Research/ Retina Research Foundation/
Joseph M. and Eula C. Lawrence Travel Scholarship Travel Grant
PROFESSIONAL EXPERIENCE:
1993-1996
Research Assistant, Department of Toxicology, Zhejiang Medical University
1996-1998
Research Assistant, Department of Disability and Human Development,
University of Illinois at Chicago
1998
Teacher Assistant, Department of Biostatistics, School of Public Health,
University of Michigan
1999 (Summer)
Biostatistician Internship, Department of Biostatistics, STATPROBE Inc.
1999-2000
Research Assistant, Department of Environmental Health Sciences,
School of Public Health, University of Michigan
2000- 2004
Biostatistician, Clinical Trial Coordinating Center, Department of Ophthalmology,
University of Pennsylvania School of Medicine
2004-
Senior Biostatistician, Clinical Trial Coordinating Center, Department of
Ophthalmology, University of Pennsylvania School of Medicine
MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES:
2001-
Society for Clinical Trials, Member
2001-
Association for Research in Vision and Ophthalmology, Member
2003-
American Statistical Association, Member
2003-
The International Biometrics Society, Member
March, 2008
Ad Hoc Grant Reviewer, National Eye Institute
May, 2009
June, 2012
Grant Reviewer, Juvenile Diabetes Research Foundation
Data Safety Monitoring Committee (DSMB) member for a NIH-funded clinical trial “Anastrozole
in Patients with Pulmonary Arterial Hypertension (AIPH) study”
EDITORIAL POSITIONS:
Reviewer:
2
2002-
Ophthalmology
2006-
Archives of Ophthalmology
2007-
Diabetes Care
2008-
The American Statistician
2009-
Journal of American Association for Pediatric Ophthalmology and Strabismus
2009-
Clinical Ophthalmology
2009-
Clinical Intervention in Aging, Clinical Medicine: Therapeutics
2010-
Statistics in Medicine
2011-
Investigative Ophthalmology & Visual Science
2011-
Pharmaceutical Statistics
2011 -
Biometrical Journal
2011-
Diabetes
2011-
Clinical Trials
2011-
Contemporary Clinical Trials
2012-
BMC Research Notes
2012-
Ophthalmic & Physiological Optics
2012-
Expert Review of Clinical Pharmacology
2012-
BMC Medical Research Methodology
2012-
Archivum Immunologiae et Therapiae Experimentalis
2012 -
Ophthalmic Epidemiology
2012-
International Journal of Ophthalmology
2012-
Journal of Biopharmaceutical Statistics
2011-
Book Editor for the book titled "Age Related Macular Degeneration",
ISBN: 978-953-307-591-4.
Editorial Board:
20122012-
Journal of Medical Sciences
Dataset Papers in Medicine
COMMITTEE MEMBERSHIPS:
Executive Committee member, Vision in Preschoolers (VIP) Study. 2004 – 2007.
Executive Committee member, Telemedicine approaches to evaluating acute-phase ROP, 2010Executive Committee member, Postnatal growth and retinopathy of prematurity (G-ROP), 2012-
PUBLICATIONS:
Research Publications, peer reviewed:
3
Schenk M, Schwartz AG, O’Neal E, Kinnard M, Greenson JK, Fryzek JP, Ying GS, Garabrant DH. Familial risk of
pancreas cancer. J Natl Cancer Inst 2001; 93:640-4.
Garabrant DH, Roth HD, Parsad R, Ying GS. Latex sensitization in health care workers and in the U.S. general
population. Am J Epidemiol 2001; 153:515-21.
Aleman TS, LaVail MM, Montemayor R, Ying GS, Maguire MG, Laties AM, Jacobson SG, Cideciyan AV.
Augmented rod bipolar cell function in partial photoreceptor loss: an ERG study in P23H rhodopsin transgenic and
aging normal rats. Vision Research 2001; 41:2779-97.
Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch
Ophthalmol 2002; 120:1435-42.
Loman J, Quinn GE, Kamoun L, Ying GS, Maguire MG, Hudesman D, Stone RA. Darkness and near work:
myopia and its progression in third-year law students. Ophthalmology 2002; 109:1032-8.
Heller T, Ying GS, Rimmer JS, Marks BA. Determinants of exercise in adults with cerebral palsy. Public Health Nurs
2002; 19:223-31.
Vannas AE, Ying GS, Stone RA, Maguire MG, Jormanainen V, Tervo T. Myopia and natural lighting extremes:
risk factors in Finnish army conscripts. Acta Ophthalmol Scand 2003; 81:588-95.
Hahn P, Lindsten T, Ying GS, Bennett J, Milam AH, Thompson CB, Dunaief JL. Proapoptotic Bcl-2 family
members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Invest Ophthalmol Vis Sci
2003; 44:3598-605.
Quinn GE, Francis EL, Nipper KS, Flitcroft DI, Ying GS, Rees R, Schmid G, Maguire MG, Stone RA. Highly
precise eye length measurements in children aged 3 through 12 years. Arch Ophthalmol 2003; 121:985-90.
Prenner JL, Rosenblatt BJ, Tolentino MJ, Ying GS, Javornik NB, Maguire MG, Ho AC, the CNVPT Research
Group. Risk factors for choroidal neovascularization and vision loss in the Fellow Eye Study of CNVPT.
Retina 2003; 23:307-14..
Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi L, Pfohl DC, Mills M, Bowen J,
Ford C, Heidenreich FR, Jacobs DA, Markowitz CE, Stuart WH, Ying GS, Galetta SL, Maguire MG, Cutter
CR. Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite. Neurology
2003; 61:1367-73.
Lee MS, Balcer LJ, Volpe NJ, Liu GT, Ying GS, Galetta SL. Laser pointer visual field screening.
Neuroophthalmol 2003; 23:260-3.
4
PUBLICATIONS - Research Publications, peer reviewed (Continued):
Stone RA, Quinn GE, Francis EL, Ying GS, Flitcroft DI, Parekh P, Brown J, Orlow J, Schmid G. Diurnal axial
length fluctuations in human eyes. Invest Ophthalmol Vis Sci 2004; 45:63-70.
Ying GS, Heitjan DF, Chen T. Nonparametric prediction of event times in randomized clinical trials. Clinical
Trials 2004; 1:352-61.
Ibarra MS, Hsu J, Mirza N, Wu I-H, Ying GS, Mainster MA, Tolentino MJ. Retinal temperature increase during
transpupillary thermotherapy: effects of pigmentation, subretinal blood, and choroidal blood flow. Invest
Ophthalmol Vis Sci 2004; 45:3678-82.
Hahn P, Lindsten T, Lyubarsky A, Ying GS, Pugh EN, Thompson CB, Dunaief JL. Deficiency of Bax and Bak
protects photoreceptors from light damage in vivo. Cell Death and Differentiation 2004; 11:1192-7.
Metelisina TI, Grunwald JE, Dupont JC, Ying GS. Effects of Niacin on the choroidal circulation of patients with
Age-related Macular Degeneration (AMD). British Journal of Ophthalmology 2004; 88:1568-72.
Roman AJ, Schwartz SB, Alman TS, Cideciyan AV, Chico JD, Windsor E, Gardner LM, Ying GS, Smilko EE,
Maguire MG, Jacobson SG. Quantifying rod photoreceptor-mediated vision in retinal degenerations: darkadapted thresholds as outcome measures. Experimental Eye Research 2005; 80:259-72.
Grunwald JE, Metelitsin TI, DuPont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes
with increasing AMD severity. Invest Ophthalmol Vis Sci 2005; 46:1033-8.
Heidary G, Ying GS, Maguire MG, Young TL. The impact of sphere on cylinder type and severity in a high
myopia cohort. Optom Vis Sci 2005, 82:244-7.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of Viagra on the ocular circulation of AMD patients.
Experimental Eye Research 2005, 81:159-64.
Kupersmith MJ, Ying GS. Ocular motor dysfunction in ocular myasthenia gravis: effects of treat. British Journal of
Ophthalmology 2005, 89:1330-4.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of systemic hypertension on foveolar choroidal blood
flow in age rated macular degeneration (AMD). British Journal of Ophthalmology 2006, 90:342-6.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Liu CC. Effect of Viagra on the retinal vein diameter in AMD
patients. Experimental Eye Research 2006, 83:128-32.
Wilson LB, Quinn GE, Ying GS, Francis EL, Schmid G, Lam A, Orlow J, Stone RA. The relation of axial length
and intraocular pressure fluctuations in human eyes. Invest Ophthalmol Vis Sci 2006, 47:1778-84.
Komaromy AM, Garg CD, Ying GS, Liu CC. The effect of head position on intraocular pressure in horses.
American Journal of Veterinary Research 2006, 67:1232-5.
Stone RA, Wilson LB, Ying GS, Liu CC, Criss JS, Orlow J, Lindstrom JM, Quinn GE. Associations between
Childhood Myopia and Parental Smoking. Invest Ophthalmol Vis Sci 2006, 47:4277-87.
Tania TY, Mills MD, Beck AD, Joos KM, Ying GS, Liu CC, Piltz-Seymour JR. Central Corneal Thickness and
Corneal Diameter in Patients with Childhood Glaucoma. Journal of Glaucoma 2006, 15:524-8.
PUBLICATIONS - Research Publications, peer reviewed (Continued):
5
Hahn P, Ying GS, Beard J, Dunaief JL. Iron levels in human retina: sex difference and increase with age.
Neuroreport 2006, 17:1803-6.
Rabinowitz MP, Grunwald JE, Karp KA, Quinn GE, Ying GS, Mills MD. Progression to severe retinopathy
predicted by retinal vessel diameter between 31 and 34 weeks of postconception age. Archives of
Ophthalmology 2007;125:1495-500.
Orlin A, Mills MD, Ying GS, Liu CC. A Comparison of Hang-Back with Conventional Recession Surgery for
Exotropia. J AAPOS 2007;11:597-600.
Cote ML, Schenk M, Schwartz AG, Vigneau FD, Kinnard M, Greenson JK, Fryzek JP, Ying GS, Garabrant DH.
Risk of other cancers in individuals with a family history of pancreas cancer. Journal of Gastrointestinal
Cancer 2007;38:119-26.
Ying GS, Heitjan DF. Weibull Prediction of Event Times in Randomized Clinical Trials. Pharmaceutical Statistics
2008; 7:107-20.
Metelitsina TI, Grunwald JE, Dupoint JC, Ying GS, Brucker AJ, Dunaief JL. Foveolar choroidal blood flow and
choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 2008;49:358-63.
Greller AL, Hoffman AB, Liu C, Ying GS, Vudathala D, Acland GM, Komáromy AM. Effects of the topically
applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs. Am J Vet Res
2008;69:273-8.
Ranchod TM, Guercio JR, Ying GS, Brucker AJ, Stoltz RA. Effect of aspirin therapy on photodynamic therapy
with verteporfin for choroidal neovascularization. Retina 2008; 28:711-6.
Skalet AH, Quinn GE, Ying GS, Gordillo L, Dodobara L, Cocker K, Fielder AR, Ells AL, Mills MD, Wilson C.
Gilbert C. Telemedicine screening for Retinopathy of Prematurity (ROP) in developing countries using digital
retinal images: A feasibility project. J AAPOS 2008; 12:252-8.
Zaveri M, Conger A, Salter A, Frohman TC, Galetta SL, Markowitz CE, Jacobs DA, Cutter GR, Ying GS,
Maguire MG, Calabresi PA, Balcer LJ, Frohman EM. Retinal Imaging by Laser Polarimetry and Optical
Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis. Archives of Neurology 2008;
65:924-8.
Ying GS, Maguire MG, Liu CC, Antoszyk A, and Complications of Age-related Macular Degeneration Prevention
Trial Research Group. Night vision and progression of Age-related Macular Degeneration (AMD) in the
Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2008; 115:1876-82.
Brown JS, Flitcroft DI, Ying GS, Francis EL, Quinn GE, Stone RA. In Vivo human choroidal thickness
measurements: Evidence of diurnal fluctuations. Invest Ophthalmol Vis Sci. 2009; 50:5-12.
Okeke CO, Quigley HA, Jampel HD, Ying GS, Plyler RJ, Jiang YZ, Friedman DS. Adherence with Topical
Glaucoma Medication Monitored Electronically: The Travatan Dosing Aid Study. Ophthalmology 2009;
116:191-9.
Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, Amado D, Ying GS, Sparrow J, Dunaief JL. Iron
chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse
stimuli. Invest Ophthalmol Vis Sci. 2009; 50:1440-7.
PUBLICATIONS - Research Publications, peer reviewed (Continued):
6
Ranchod TM, Brucker AJ, Liu CC, Cukras CA, Hopkins TB, Ying GS. Evaluation of actual versus expected PDT
spot size. Am J Ophthalmol. 2009; 147:859-64.
Friedman DS, Okeke CO, Jampel HD, Plyler RJ, Ying GS, Jiang YZ, Quigley HA. Risk factors of poor adherence
with eyedrops in electronically monitored glaucoma patients. Ophthalmology 2009; 116:1097-1105.
Grunwald L, Mills MD, Johnson K, Karp KA, Quinn GQ, Ying GS, Grunwald JE. Does change in retinal vessel
diameter over time predict severe retinopathy of prematurity? Am J of Ophthalmol 2009; 147:1086-1091.
Hahn P, Song Y, Ying GS, He X, Beard J, Dunaief JL. Age-dependent and gender-specific changes in mouse
tissue iron by strain. Experimental Gerontology 2009; 44:594-600.
Iacovelli J, Mlodnicka AE, Veldman P, Ying GS, Dunaief JL, Schumacher A. Brain and retinal ferroportin 1
dysregulation in polycythaemia mice. Brain Res. 2009; 1289:85-95.
Ying GS, Maguire MG, Alexander J, Martin R, Antoszyk A. Description of the AREDS 9-step severity scale
applied to participants in CAPT. Archives of Ophthalmology 2009;127:1147-51.
Shah DN, Wilson C, Ying GS, Karp K, Fielder A, Ng J, Mills MD, Quinn GE. Semiautomated digital image
analysis of posterior pole vessels in retinopathy of prematurity. J APPOS 2009;13:504-6.
Shah DN, Karp K, Ying GS, Mills MD, Quinn GE. Image analysis of posterior pole vessels identifies type I
retinopathy of prematurity. J APPOS 2009;13:507-8.
Volpe NJ, Dadvand L, Kim SK, Maguire MG, Ying GS, Moster ML, Galetta SL, M. D. Computerized Binocular
Pupillography of the Swinging Flashlight Test Detects Afferent Pupillary Defects. Current Eye Research
2009;34:606-13.
Maguire AM, High KA, Auriccho A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli J, Ying GS, Rossi S,
Marshall KA, Banfi S, Chung D, Morgan JA, Hauck B, Zelanaia O, Zhu X, Raffini L, Coppieters F, Elfride
DB, Schindler K, Volpe N, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, , McDonnell
JW, Leroy BP, Simonelli F, Bennett J. Phase I gene therapy shows reversal of congenital blindness: Agedependent effect of treatment. Lancet 2009; 374:1597-605.
Maguire MG, Ying GS, McCannel C, Liu CC. Dai Y. Statin use and the incidence of advanced age-related macular
degeneration in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT).
Ophthalmology 2009;116:2381-5.
Okeke CO, Quigley HA, Jampel HD, Ying GS, Plyler RJ, Jiang YZ, Friedman DS. Interventions Improve Poor
Adherence with Once Daily Glaucoma Medications in Electronically Monitored Patients. Ophthalmology:
2009;116:2286-93.
Garcia MM, Ying GS, Cocores CA, Tanaka JC, Komaromy AM. Behavioral method form objective vision testing and
identification of achromatopsia in dogs. Am J Vet Res 2010;71:97-102.
7
PUBLICATIONS - Research Publications, peer reviewed (Continued):
Simonelli F, Maguire AM, Testa F ,Pierce EA, Mingozzi F, Bennicelli J, Rossi S, Marshall K, Banfi S, Surace
EM, Sun J, Redmond M, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, DcDonnel JW, High
KA, Bennett J, Auricchio A. Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5
years after vector administration. Molecular Therapy 2010; 18:643-50.
Zaida AA, Ying GS, Daniel E, Gangaputra S, Rosenbaum JT, Suhler EB, Throne JE, Foster CS, Jabs DA, LevyClarke GA, Nussenblatt RB, Kempem JH. Hypopyon in patients with uveitis. Ophthalmology 2010; 117:36672
Cyert L, Ying GS, Dobson V, Quinn G, Magure M, Kulp MT, Ciner E, Schmidt P, Moore B, and Vision in
Preschoolers (VIP) Study Group. Age Comparison for Lea Symbols and HOTV in Preschool Vision Screening.
Optom Vis Sci 2010:87:87-95.
Ying GS, Dobson V, Quinn G, Maguire M, Kulp MT, Cyert L and Vision in Preschoolers (VIP) Study Group. Impact
of Confidence Number on the Accuracy of SureSight Vision Screener. Optom Vis Sci 2010;87:96-103.
Ghodasra DH, Karen KA, Ying GS, Mills MD, Wilson C, Fielder AR, Ng J, Quinn GE. Risk stratification of eyes
with preplus ROP by semi-automated analysis of digital images. Arch Ophthalmol. 2010; 128:719-23.
Talman LS, Sackel D, Long DA, Bisker ER, Ratchford JN, Farrell SK, Loguidice MJ, Conger A, Frohman TC,
Jacobs DA, Markowitz CE, Cutter GR, Ying GS, Dai Y, Maguire MG, Galetta SL, Frohman EM, Calabresi
PA, Balcer LJ. Longitudinal study of vision and retinal nerve fiber layer thickness in MS. Ann Neurol 2010;
67:749-60.
Xu W, Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Martin ER, Dunaief JL, Brucker AJ. Risk factors for
choroidal neovascularization in AMD are associated with decreased foveolar choroidal circulation. Am J of
Ophthalmol 2010; 150:40-47.
Stone RA, Ying GS, Pearson DJ, Dansal M, Puri M, Miller E, Alexander J, Piltz J, Nyberg W, Maguire MG,
Eledath J, Sawhney H. Utility of dignitial stereo images for optic disc evaluation. Invest Ophthalmol Vis Sci
2010; 51:5667-5674.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of isometric exercise on choroidal blood flow in
patients with age-related macular degeneration (AMD). British Journal of Ophthalmology 2010; 94:1629-31.
Ying GS, Maguire MG, and the CAPT Research Group. Development of a Risk Score for Geographic Atrophy
(GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 2011;
118:332-8.
Tamhankar MA, Kim JH, Ying GS, Volpe NJ. Adult hypertropia: a guide to diagnostic evaluation based on review
of 300 patients. Eye 2011; 25:91-6.
Binenbaum G, Ying GS, Quinn GE, Dreiseitl S, Karp K, Roberts RS, Kirpalani H, and the Premature Infants in
Need of Transfusion Study Group. A Clinical prediction model to stratify ROP risk using postnatal weight
gain. Pediatrics 2011; 127:607-614.
Tamhankar MA, Ying GS, Volpe NJ. Effectiveness of prisms in the management of diplopia due to fourth nerve
palsy. J Neuroophthalmology 2011; 31:206-9.
PUBLICATIONS - Research Publications, peer reviewed (Continued):
8
Shah DN, Wilson CM, Ying GS, Karp KA, Cocker KD, Fielder A, Mill MD, Quinn EQ. Comparison of expert
graders to computer assisted image analysis of the retina in Retinopathy of Prematurity. Br J Ophthalmol.
2011; 95:1442-5.
Jensen AK, Ying GS, Huang JY, Karp K, Quinn GE, Binenbaum G. Thrombocytopenia and retinopathy of
prematurity. J APPOS 2011, 15(1): e3-e4.
Smolen H, Ying GS, Martin ER, Maguire MG. New grading criteria allow for earlier detection of geographic
atrophy in clinical trials. Invest Ophthalmol Vis Sci 2011, 52(12):9218-9225
Ying GS, Maguire MG, Quinn G, Kulp MT, Cyert L, and Vision in Preschoolers (VIP) Study Group. ROC
analysis of the accuracy of noncycloplegic retinoscopy, Retinomax autorefractor and SureSight Vision Screener
for Preschool vision screening. Invest Ophthalmol Vis Sci 2011; 52:9658-9664.
Berenberg TL, Metelitsina TI, Madow B, Dai Y, Ying GS, DuPont JC, Grunwald L, Brucker AJ, Grunwald JE.
The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration.
Retina 2012, 32:25-31.
Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y,
Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High
KA, Maguire AM. AAV2 gene therapy readministration in three adults with Congenital blindness. Science
Translational Medicine 2012, 4:120ra15.
Tamhankar MA, Ying GS, Volpe NJ. Effectiveness of prisms in the management of diplopia in patients due to
diverse etiolgies. J Pediatric Ophthalmology & Strabismus 2012, Feb 28:1-7 [Epub ahead of print]..
Mehta SM, Loevner LA, Mikityansky I, Langlotz C, Ying GS, Tamhankar MA, Shindler K, Volpe NJ.The
diagnostic and economic yield of neuroimaging in neuro-ophthalmology. J Neuroophthalmol. 2012; 32:139144.
Charkoudian LD, Ying GS, Pujari SS, Gangaputra S, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA,
Nussenblatt RB, Rosenbaum JT, Suhler EB, Kempen JH. High-dose intravenous corticosteroids for ocular
inflammatory diseases. Ocul Immunol Inflamm 2012, 20(2):91-99.
Udoetuk JD, Dai Y, Ying GS, Daniel E, Gangaputra S, MD, MPH, Rosenbaum JT, Kempen JH.
Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye
diseases. Ophthalmology 2012; 119:1569-74.
Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, deZoeten E, Dunaief JL. DNA
Methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci. 2012, 53:2089105.
Grunwald JE, Ying GS, Maguire M, Pistilli M, Daniel E, Alexander J, Whittock-Martin R, Parker C, Mohler E, Lo JC,
Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Coleman M, Keane
MG and CRIC Study Group. Association between retinopathy and cardiovascular disease in patients with Chronic
Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Cardiol. 2012,
110:246-53.
Tamhankar MA, Ying GS, Volpe NJ. Prisms are effective in resolving diplopia from incomitant, large and
combined strabismus. Eur J Ophthalmol. 2012 Mar 29:0. doi: 10.5301/ejo.5000144. [Epub ahead of print]
PUBLICATIONS - Research Publications, peer reviewed (Continued):
9
Shindler KS, Revere K, Dutt M, Ying GS, Chung DC. In Vivo detection of experimental optic neuritis by
pupillometry. Experimental Eye Research. 2012; 100:1-6
Kwon JY, Ghodasra DH, Ying GS, Wilson CM, Karp KA, Huang JY, Mills MD, Fielder AR, Quinn GE. Retinal
vessel changes after laser treatment for retinopathy of prematurity. J APPOS 2012; 16;350-3.
Khitri MR, Mills MD, Ying GS, Davidson SL, Quinn GE. Visual acuity in pediatric glaucomas. J APPOS 2012;
16:376-81.
Grunwald JE, Daniel E, Ying GS, Pistilli M, Maguire MG, Alexander J, Whittock-Martin R, Parker CR, Sepielli
K, Blodi BA, Martin DF, and CATT Research Group. Photographic Assessment of Fundus Morphology in the
Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology 2012;
119:1634-41.
Grunwald JE, Alexander J, Ying GS., Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go
A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek J, Xie D, Jaar,BG The CRIC
Study Group. Retinopathy and Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort (CRIC) Study.
Arch.Ophthalmol. 2012;130:1136-1144.
Dunaief DM, Fuhrman J, Dunaief JL, Ying GS. Glycemic and cardiovascular parameters improved in type 2 diabetes
with the high nutrient density (HND) diet. Journal of Preventive Medicine 2012; 3:364-371.
Ghodasa DH, Thuangtong A, Karp K, Ying GS, Mills M, Wilson CM, Fielder AR, Ng J, Quinn GE. The rate of
Change in retinal vessel width and tortuosity in eyes at risk for retinopathy of prematurity. J AAPOS 2012;
16:431-6.
Ying GS, Huang J, Maguire MG, Jaffe GJ, Grunwald JE, Cynthia T, Daniel E, Klein M, Pieramici D, Wells J,
Martin DF, and CATT Research Group. Baseline predictors for one year visual outcomes with Ranibizumab or
Bevacizumab for Neovascular Age-related Macular Degeneration. Ophthalmology 2012 [Epub ahead of print].
Ying GS, Huang J, Maguire MG, Quinn G, Kulp MT, Ciner E, Cyert L, Orel-Bixler D, and Vision In Preschoolers
(VIP) Study Group. Association of anisometropia with unilateral amblyopia, interocular acuity difference and
stereoacuity in preschoolers. Ophthalmology 2012 [Epub ahead of print].
Binebaum G, Ying GS, Quinn G, Huang J, Dreiseitl S, Antigua J, Forough N, Abbasi S. The CHOP postnatal weight
gain, birth weight, and gestational age retinopathy of prematurity risk model. Archives Ophthalmology 2012;
130(12):1560-5.
Hadziahmetovic M, Pajic M, Grieco S, Song Y, Li Y, Cwanger A, Iacovelli J, Chu S, Ying GS, Connelly J, Spino M,
Dunaief J. The Oral iron chelator deferiprone protects against retinal degeneration induced through diverse
mechanisms. Transitional vision science & technology 2012 (in press).
Hagstrom S, Ying GS, Pauer GJ, et al. for the CATT Research Group. Pharmacogentics of anti-VEGF therapy in
the Comparison of AMD Treatments Trials (CATT). Ophthalmology 2012 (in press).
Yaffe K, Ackerson L, Hoang TD, Go AS, Maguire MG, Ying GS, Daniel E, Bazzano LA, Coleman M, Cohen DL,
Glenn M, Kusek JW, Ojo A, Seliger S, Xie D, Gunwald GE, and CRIC Study Investigators. Retinopathy and
cognitive impairment among older adults with chronic kidney disease. American Journal of Kidney Diseases
2012.[Epub ahead of print].
Cohen AM, Cook N, Harris MC, Ying GS, Binebaum G. The pain response to mydriatic eye drops in preterm
infants. J. Perinatol. Dec. 13, 2012. [EPub ahead of Print].
Ying GS, Heitjan DF. Prediction of Event times in the REMATCH Trial. Clinical Trials (in press).
10
Contributions to peer-reviewed clinical research publications as a writing team leader or member:
Choroidal Neovascularization Prevention Trial Research Group (Writing team member). Laser treatment in fellow
eyes with large drusen: updated findings from a pilot randomized clinical trial. Ophthalmology 2003; 110:971-8.
Vision in Preschoolers (VIP) Study Group (Writing team member, Biostatistician for the Coordinating Center).
Visual acuity results in school-aged children and adults: Lea Symbols chart versus Bailey-Lovie chart. Optom Vis
Sci 2003; 80:650-4.
Vision in Preschoolers (VIP) Study Group (Writing team member; Biostatistician for the Coordinating Center).
Comparison of Preschool Vision Screening Tests as Administered by Licensed Eyecare Professionals in the Vision
in Preschoolers (VIP) Study. Ophthalmology 2004; 111:637-50.
Complications of Age-related Macular Degeneration Prevention Trial Research Group (Writing team leader,
Biostatistician for the Coordinating Center). Baseline Characteristics, the NEI-VFQ-25, and Their Associations in
the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 2004;
111:1307-16.
Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating Center).
Sensitivity of screening tests for detecting VIP-targeted vision disorders when specificity is 94%. Optom Vis Sci
2005; 82:432-8.
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Preschool vision screening tests administered by nurse screeners compared to lay screeners in the Vision in
Preschoolers Study Invest Ophthalmol Vis Sci 2005; 46:2639-48.
Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Writing team member,
Senior Biostatistician for the Coordinating Center). Laser treatment in patients with bilateral large drusen - The
Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2006; 113:1974-86.
Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating
Center).Impact of confidence number on the screening accuracy of the Retinomax Autorefractor. Optom Vis Sci
2007; 84:181-188.
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Does Assessing eye alignment along with refractive error or visual acuity increase sensitivity for detection
of strabismus in Preschool Vision Screening? Invest Ophthalmol Vis Sci. 2007; 48:3115-3125.
Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Writing team leader, Senior
Biostatistician for the Coordinating Center). Risk factors for Choroidal Neovascularization and Geographic
Atrophy in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 2008;
115:1474-79.
Contributions to peer-reviewed clinical research publications as a writing team leader or member (Cont’d):
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Findings from the Vision in Preschoolers (VIP) Study. Optom Vis Sci. 2009;86:619-23.
11
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Comparison of Retinomax and Palm-AR Auto-Refractors: A Pilot Study. Optom Vis Sci. 2011;88:830836.
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Age Comparison for Lea Symbols and HOTV in Preschool Vision Screening. Optom Vis Sci 2010:87:8795.
Vision in Preschoolers (VIP) Study Group (Writing team leader; Senior Biostatistician for the Coordinating Center).
Impact of Confidence Number on the Accuracy of SureSight Vision Screener. Optom Vis Sci 2010;87:96-103.
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Comparison of the Retinomax Autorefractor and Palm-automatic refractometer: a pilot study in the Vision
in Preschoolers Study. Optom Vis Sci.2011;88:830-6.
Comparison of AMD Treatment Trials (CATT) Study Group. (One of the 6 Writing team member; Senior
Biostatistician for the Coordinating Center). Ranibizumab and Bevacizumab for Neovascular Age-related
Macular Degeneration(AMD). New England Journal of Medicine 2011, 364:1897-908.
Comparison of AMD Treatment Trials (CATT) Study Group. (One of the 9 Writing team member; Senior
Biostatistician for the Coordinating Center). Ranibizumab and Bevacizumab for Treatment of Neovascular
Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology 2012, 119:1388-98.
Contributions to peer-reviewed clinical research publications, participation cited or acknowledged but not by
authorship:
Vision in Preschoolers (VIP) Study Group (Writing team member; Senior Biostatistician for the Coordinating
Center). Preschool vision screening: evidence-based guidelines from the Vision in Preschoolers (VIP) Study.
Submitted to Pediatrics.
Complications of Age-related Macular Degeneration Prevention Trial Research Group. (Ying GS as Biostatistician for
the Coordinating Center). The Complications of Age-related Macular Degeneration Prevention Trial (CAPT):
Rationale, design and methodology. Clinical Trials 2004; 1:91-107.
The Age-Related Macular Degeneration Radiotherapy Trial (AMDRT) Research Group. (Ying GS as Biostatistician for
the Coordinating Center). The Age-Related Macular Degeneration Radiotherapy Trial (AMDRT): One year results
from a pilot study. Am J Ophthalmol 2004; 138:818-28.
Vision In Preschoolers (VIP) Study Group. (Ying GS as Biostatistician for the Coordinating Center). Development and
implementation of a Preschool Vision Screening program in a mobile setting. NHSA Dialog 2005; 8:16-24.
Kulp MT, Vision in Preschoolers Study Group (Ying GS as Senior Biostatistician for the Coordinating Center).
Findings from the Vision in Preschoolers (VIP) Study. Optom Vis Sci. 2009; 86:619-23.
Soltz RA, Carolyn GH, Tolentino MJ, Maguire AM (Ying GS acknowledged). Transmission of retinal wavelengths
though blood. Retina 2005; 25:498-502.
Beltran WA, Hammond P, Acland GM, Aguirre GD (Ying GS acknowledged). A frameshift mutation in RPGR exon
ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa.
Invest Ophthalmol Vis Sci 2006; 47:1669-81.
Vision in Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Predictive
value of photoscreening and traditional screening of preschool children. J AAPOS 2006; 10:377-8.
12
Vision In Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Children
unable to perform screening tests in Vision In Preschoolers Study: Proportion with ocular conditions and impact on
the measures of test accuracy. Invest Ophthalmol Vis Sci 2007; 48:83-87.
Vision In Preschoolers (VIP) Study Group (Ying GS as Senior Biostatistician for the Coordinating Center). Random
Dot E stereotest: Testability and reliability in 3- to 5-year-old children. J AAPOS 2006; 10:507-14.
Murphy BR, Moayedpardazi HS, Gewirtz AM, Diamond SL, Pierce EA (Ying GS acknowledged). Delivery and
mechanistic considerations for the production of knock-in mice by single-stranded olignucleotide gene targeting.
Gene Therapy 2006; 5:1-12
Roman AJ, Boye SL, Aleman TS, Pang JJ, McDowell JH, Boye SE, Jacobson SG, Hauswirth WW (Ying GS
acknowledged). Electroretinographic analyses of Rpe65-mutant rd12 mice: Developing an in vivo bioassay for
human gene therapy trials of Leber congenital amaurosis. Molecular Vision 2007;13:1701-10.
Ying X, Sulaiman P, Feddresen R, Liu J, Smith RG, Vardi N (Ying GS acknowledged). Retinal ON bipolar cells
express a new PCP2 splice variant that accelerates the light response. The Journal of Neuroscience 2008; 28:887384.
Chen W, Stambolian D, Edwards AO et al (Ying GS as member of CAPT Data Coordinating Center
acknowledged). Genetic variants TIMP3 and high-density lipoprotein-associated loci influence susceptibility to
age-related macular degeneration. Proc Natl Acad Sci USA 2010; 107:7401-6.
13
ABSTRACTS, Past 5 years:
Ying GS, Vision in Preschoolers Study Group. Impact of confidence number on the accuracy of the Retinomax and
SureSight autorefractors as screening tools. IOVS 2006; 47:ARVO E-Abstract 693.
Glassman RD, Wilson LB, Quinn GE, Francis EL, Ying GS, Orlin A, Orlow J, Schmid GF, Stone RA. The relation of
axial length and corneal thickness fluctuations in human eyes. IOVS 2006; 47:ARVO E-Abstract 1798.
Grunwald JE, Metelitsina TI, DuPont JC, Ying GS. Decreases in the foveal chroidal circulation precede the appearance
of choroidal neovascularization (CNV) in age related macular degeneration (AMD). IOVS 2006; 47:ARVO EAbstract 2167.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Alexander J, Martin RE, Matias KM. Association between agerelated macular degeneration (AMD) fundus feature and foveal choroidal circulation. IOVS 2006; 47:ARVO EAbstract 2169.
Stone RA, Criss JS, Wilson LB, Quinn GE, Ying GS, Liu CC, Orlow J, Lindstrom JM. Childhood refraction:
Associations with parental smoking. IOVS 2006; 47:ARVO E-Abstract 5456.
Wilson LB, Madjarov BD, Liu CC, Ying GS, Ells AL, Fielder A, Cocker K, Mills M, Davidson S, Quinn GE. Can
digital ROP images be optimized for remote readers? IOVS 2006; 47:ARVO E-Abstract 5298.
Lei T, Odhner D, Mishra S, Schwarta E, Ying GS, Iwanaga T, Desiderio L, Balcer L. A methodology to study multiple
sclerosis (MS) based on distributions of standardized intensities in segmented tissue regions. SPIE 2005 annual
conference paper.
Ying GS, Folk J, CAPT Research Group. Risk factors for Choroidal Neovascularization and Geographic Atrophy in the
Complications of Age-related Macular Degeneration Prevention Trial (CAPT). IOVS 2007; 48:ARVO E-Abstract
1153.
Grunwald L, Niknam RM, Ying GS, Sankar P, Nduaguba C, Miller E. Effect of corneal thickness on intraocular
pressure reduction. IOVS 2007; 48:ARVO E-Abstract 1279.
Ranchod TM, Brucker AJ, Liu C, Ying GS, Cukras CA, Hopkins TB. Evaluation of actual versus expected PDT spot
size. IOVS 2007; 48:ARVO E-Abstract 1800.
Liu C, Maguire M, Ying GS, CAPT Research Group. Refractive error in the complications of Age-related Macular
Degeneration Prevention Trial (CAPT): Risk of late AMD and 5-year changes. IOVS 2007; 48:ARVO EAssociation for Research in Vision and Ophthalmology. Abstract 2090.
Baumritter A, Clark CM, Martin R, Steinberg JD, Stoltz RA, Ying GS. Prevalence of Age-related Macular
Degeneration among patients with Alzheimer’s Disease. IOVS 2007; 48:ARVO E-Abstract 2092.
Metelitsina TI, Figueroa M, Schocket LS, Ying GS, Dupoint JC, Alexander J, Grunwald JE. Laser induced resolution
of drusen is associated with increases in choroidal blood flow. IOVS 2007; 48:ARVO E-Abstract 2150.
ABSTRACTS, Past 5 years (Cont’d):
14
Grunwald JE , Metelitsina TI, Dupoint JC, Ying GS. Decreases in choroidal circulation precede choroidal
neovascularization (CNV) formation and visual acuity loss in Age-related Macular Degeneration (AMD). IOVS
2007; 48:ARVO E-Abstract 2153.
Rabinowitz MP, Grunwald JE, Karp KA, Quinn GE, Ying GS, Mills MD. Does retinal vessel diameter between 31 and
34 weeks post-conceptional age predict progression to severe retinopathy? IOVS 2007; 48:ARVO E-Abstract
3089.
Grunwald L, Mills MD, Johnson K, Karp KA, Ying GS, Grunwald JE. Does change in retinal vessel diameter over
time predict severe retinopathy of prematurity? IOVS 2008; 49:ARVO E-Abstract 1383.
Nemani D, Wilsonm CM, Karp KA, Ying GS, Maguire M, Prince JB, Ng J, Fielder AR, Mills MM, Quinn GE.
Semi-automated digital image analysis for eyes with and without retinopathy of prematurity (ROP). IOVS
2008; 49:ARVO E-Abstract 1384.
Ying GS, Maguire MG, Alexander J, Martin RW, Antoszyk AN, and the CAPT Research Group. The AREDS 9step AMD severity scale applied to participants in the Complications of Age-related Macular Degeneration
Prevention Trial (CAPT): Baseline classification, risk of advanced AMD, and longitudinal path analysis. IOVS
2008; 49:ARVO E-Abstract 1762.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS. Effect of iosmetric exercise on cloroidal blood flow in patients
with age-related macular degeneration (AMD). IOVS 2008; 49:ARVO E-Abstract 2240.
Garcia MM, Cocores C, Ying GS, Tanaka JC, Komaromy AM. Behavioral test for visual assessment of Canine
Achromatopsia. IOVS 2008; 49:ARVO E-Abstract 3839.
Berenberg TL, Metelitsina TI, DuPont JC, Madow B, Dai Y, Ying GS, Brucker A., Grunwald JE. Association
Between Drusen Extent and Foveolar Choroidal Blood Flow in AMD. IOVS 2009; 49:ARVO E-Abstract 231.
Grunwald GE, Metelitsina RI, Dupont JC, Ying GS, Xu W, Martin ER, Brucker AJ. Risk Factors for Choroidal
Neovascularization in Age-Related Macular Degeneration (AMD) Are Associated With Decreased Foveolar
Choroidal Circulation. IOVS 2009; 49:ARVO E-Abstract 234.
Maguire MG, Ying GS. Evaluation of Incident Advanced Age-Related Macular Degeneration and of Progression
on the AREDS 9-Step Severity Scale as Surrogate Outcome Measures in Clinical Trials. IOVS 2009;
49:ARVO E-Abstract 263.
Bisker E, Chang S, Conger A, Hiremath G, Dai Y, Ying GS, Maguire M, Frohman E, Calabresi P, Balcer L.
Clinical and Ocular Imaging Characteristics of Eyes With Visual Loss Over Time in Multiple Sclerosis. IOVS
2009; 49:ARVO E-Abstract 927.
Ying GS, Maguire MG, and the CAPT Research Group. Development of a Risk Score for Geographic Atrophy
(GA) in Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). IOVS 2009;
49:ARVO E-Abstract 1662.
ABSTRACTS, Past 5 years (Cont’d):
Grunwald L, Mills MD, Ying GS, Karp KA, Grunwald JE, Dai Y, Fiorin D, Quinn GE. Retinal Vessel Width in
Infants at Risk for Retinopathy of Prematurity Between 31 and 34 Weeks Post-Menstrual Age. IOVS 2009;
15
49:ARVO E-Abstract 3134.
Ghodasra DH, Karp KA, Ying GS, Wilson C, Fielder AR, Mills MD, Quinn GE. Predicting the Progression of
ROP With Preplus. IOVS 2009; 49:ARVO E-Abstract 3135.
Smolen H, Ying GS, Martin ER, Maguire MG, and the CAPT Research Group. Characteristics of Early
Geographic Atrophy in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT).
IOVS 2009; 49:ARVO E-Abstract 3915.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Xu W, Martin RE, Drucker AJ. Association Between
Geographic Atrophy and Choroidal Blood Flow Parameters in Age-Related Macular Degeneration (AMD).
IOVS 2009; 49:ARVO E-Abstract 4916.
Stone RA, Ying GS, Pearson D, Bansal M, Puri M, and the CODA Study Group. Utility of Stereo Digital Images
for Optic Disc Evaluation. IOVS 2009; 49:ARVO E-Abstract 5808.
Wang J, Gu Y, Chen Y, Zhou W, Ying GS. Prevalence and causes of visual disability in the Eastern China. IOVS
2010; 49:ARVO E-Abstract 131.
Maguire MG, Ying GS, Ciner E, Cyert L, Kulp MT, and Vision in Preschoolers Study Group. Prevalence of vision
disorders by racial and ethnic group among children participating in Head Start. IOVS 2010; 49:ARVO EAbstract 138.
Ying GS, Maguire MG, Dobson V, Quinn GE, Kulp MT, Cyert L, and Vision in Preschoolers Study Group.
Validity of noncycloplegic retinoscopy, retinomax autorefractor and suresight vision screener for detecting
VIP-targeted eye conditions. IOVS 2010; 49:ARVO E-Abstract 1704.
Canver MS, Revere KE, Ying GS, Canver AC, Bennett J, Chung DC. Impairment of papillary light responses in
Murine Models of retinal degeneration. IOVS 2010; 49:ARVO E-Abstract 4048.
Charkoudian LD, Ying GS, Thorne JE, Foster C Jabs DA, Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB,
Kempen JH. Intravenous pulsed corticosteroids for ocular inflammatory diseases. IOVS 2010; 49:ARVO EAbstract 5257.
Grunwald L, Ying GS, Quinn GE, Dai Y, Karp KA, Fiorin D, Ruggeri A, Grunwald JE, Mills MD. Retinal vessel
tortuosity in infants at risk for retinopathy of prematurity between 31 and 34 weeks post-menstrual age. IOVS
2010; 49:ARVO E-Abstract 5919.
Ghodasa DH, Thuangtong A, Karp K, Ying GS, Mills M, Wilson CM, Fielder AR, Ng J, Quinn GE. Change in
retinal vessel width and tortuosity in eyes at risk for retinopathy of prematurity. IOVS 2010; 49:ARVO EAbstract 5925.
Wang YZ, Ying GS, Mitzel G, He YG. Sensitivity and specificity of shape discrimination hyperacuity for
discriminating exudating AMD from moderate AMD. 2011 ARVO E-Abstract 100.
Iwabe S, Ying GS, Aguirre GD, Beltran WA. Visual behavior and retinal structure following acute light exposure
in normal and T4R RHO dogs. 2011 E-Abstract 1352.
ABSTRACTS, Past 5 years (Cont’d):
Simon MA, Forbes BJ, Christian CW, Ichord RN, Ying GS, Romero K, Binenbaum G. Association between retinal
hemorrhage and pediatric brain injury patterns on diffusion-weighted magnetic resonance imaging. 2011 EAbstract 1569.
16
Kulp MT, Ying GS, Huang J, Maguire MG, Quinn GE, Ciner E, Cyert LA, Moore B, Orel-Bixler DA.
Validity of noncycloplegic retinoscopy, retinomax autorefractor and SureSight vision screener for
detecting significant refractive errors. 2011 E-Abstract 1601.
Rhodes JL, Iwabe S, Ying GS, Huang J, Komaromy AW. Measurement of retinal thickness in Canine models of
outer retinal disease using Spectral Domain Optical Coherence Tomography (SD-OCT). 2011 E-Abstract
1729.
Kown JY, Karp K, Ghodasra DH, Ying GS, Wilson CM, Fielder AR, Quinn GE. Quantitative analysis of retinal
vessel parameters following ROP treatment. 2011 E-Abstract 3145.
Jensen A, Huang J, Ying GS, Quinn GE, Karp K, Binenbaum G. Exploring critical windows in the association
between serum platelet deficit and retinopathy of prematurity. 2011 E-Abstract 3395.
Pistilli M, Ying GS, Maguire MG, Peskin EP, Dentone PG, Asbell PA, and DREAM Research Group. Symptom
Questionnaires for Dry Eye Disease: A comparative Rasch Analysis of the OSDI, BODI and IDEEL. 2011 EAbstract 3865.
Ying GS, Huang J, Maguire MG, Quinn GE, Kulp MT, Ciner E, Cyert LA, Baumritter A, and Vision in
Preschoolers (VIP) Study Group. Association between amblyopia and sperical and cylindrical anisometropia
in Preschoolers. 2011 E-Abstract 6328.
Huang J, Ying GS, Maguire MG, Quinn GE, Kulp MT, Ciner E, Cyert LA, Baumritter A, and Vision in
Preschoolers (VIP) Study Group. The Association between anisometropia measured by vector analysis and
unilateral amblyopia in Preschoolers. 2011 E-Abstract 6330.
EDITORIALS, LETTERS TO THE EDITOR, CHAPTERS, COMMITTEE REPORTS, PROCEEDINGS:
Ying GS, Huang XS. The methods for assaying the estrogenicity of environmental xenoestrogens (Review). Journal of
Foreign Medicine - Public Health Division 1995; 22:216-9.
Ying GS. The primary culture of Sertoli cells and its use in testicular toxicity assay of diethylstilbestrol, casmium , and
endosulfan. Master Thesis (advisor: Xingshu Huang). Zhejiang Medical University, Hangzhou, Zhejiang, June
1996.
Garabrant DH, Ying GS. Case-control study of leukemia and lymphoma at the Ford Sharonville plant. Report
submitted to United Auto Workers/Ford Motor Company and National Joint Committee on the Health and Safety,
1999.
Garabrant DH, Roth HD, Parsad R, Ying GS. Author reply Re: Latex sensitization in health care workers and in the US
general population. Am J Epidemiol 2001; 153:527-8.
Garabrant DH, Roth HD, Parsad R, Ying GS. Author reply Re: Latex sensitization in health care workers and in the US
general population. Am J Epidemiol 2001; 154:190-1.
Garabrant DH, Pastula S, Fryzek J, Ying GS. A mortality study of the Transmission & Chassis and Stampling plant
workers. Report submitted to United Auto Workers/Ford Motor Company and National Joint Committee on Health
and Safety, 2002.
Ying GS. Prediction of event times in randomized clinical trials. Ph.D. Dissertation (advisor: Daniel F Heitjan. Ph.D.).
University of Pennsylvania, Philadelphia, Pennsylvania, May 2004.
17
Maguire MG, Fine SL, Ying GS. Intravitreal injection of VEGF siRNA (Correspondence). Retina 2005; 25: 101-2.
Ying GS, Liu CC. Analysis of the clustered data using SAS® systems. NESUG Conference Proceedings. 2006.
Mills MD, Orlin A, Ying GS. Response to a Letter to the Editor Re: A Comparison of Hang-Back with
Conventional Recession Surgery for Exotropia. J AAPOS 2008; 12:215-6.
Mills MD, Quinn GE, Grunwald JE, Ying GS, Karp K, Rabinowitz M. Author Reply Re: Retinal vessels and
Retinopathy of Prematurity. Archives of Ophthalmology 2008; 126:869-70.
Ying GS, Maguire MG. Account for correlation in regression analysis of longitudinal data from paired eyes. JSM
Proceedings 2008; 1190-97.
Ying GS. Is Drusen Really So Important? Invest Ophthalmol Vis Sci 2012;53:4407-4408.
18
PRESENTATIONS:
Non-parametric prediction of event times in randomized clinical trials. ENAR Spring meeting. Pittsburgh,
Pennsylvania. March, 2004.
Night-vision symptoms as a risk factor for vision loss, choroidal neovascularization, and geographic atrophy in the
Complications of Age-related Macular Degeneration Prevention Trial (CAPT). 131st Anniversary Meeting of
Department of Ophthalmology, University of Pennsylvania. May, 2005.
Weibull predictions of event times in randomized clinical trials. 26th annual meeting of Society of Clinical Trials.
Portland, Oregon. May, 2005.
Weibull predictions of event times in randomized clinical trials. Sanofi-Aventis, Malvern, PA. July 27, 2005.
Predictions of patient enrollment in randomized clinical trials. 27th annual meeting of Society of Clinical Trials.
Orlando, FL. May 23, 2006.
Real-time Predictions of event times in randomized clinical trials. New Researchers Meeting, Seattle, WA. August
1-5, 2006.
Analysis of clustered data using SAS® systems. NESUG 2006. Philadelphia, PA. September 19, 2006.
Night vision and risk of vision loss, choroidal neovascularization, and geographic atrophy in the Complications of
age-related Macular Degeneration Prevention Trial (CAPT). 4th U.S. Symposium on Ocular Epidemiology.
Sarasota, Florida. January 31, 2007.
Risk Factors for Choroidal Neovascularization (CNV) and Geographic Atrophy (GA) in the Complications of Agerelated Macular Degeneration Prevention Trial (CAPT). Association for Research in Vision and
Ophthalmology Annual Meeting. Fort Lauderdale, Florida. May 8, 2007.
Real-time prediction of patient accrual and trial length that minimizes cost in randomized clinical trials. 28th Society
of Clinical Trial Annual Meeting. Montreal, Canada. May 22, 2007.
Different risk factors for Choroidal Neovascularization (CNV) and Geographic Atrophy (GA): Results from the
Complications of Age-related Macular Degeneration Prevention Trial (CAPT). 133rd Anniversary Meeting of
Department of Ophthalmology, University of Pennsylvania. June, 2007.
Prediction of patient accrual and trial length that minimizes cost in randomized clinical trials. The First International
Symposium on Biopharmaceutical Statistics. Shanghai, China, June 30 – July 2, 2008.
Account for correlation in regression analysis of longitudinal data from paired eyes. Joint Statistical Meeting,
Denver, August 3, 2008.
Development of a Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular
Degeneration Prevention Trial (CAPT). Association for Research in Vision and Ophthalmology Annual
Meeting. Fort Lauderdale, Florida. May 4, 2009.
Risk Score for Geographic Atrophy (GA) in Complications of Age-Related Macular Degeneration Prevention Trial
(CAPT). 135th Anniversary Meeting of Department of Ophthalmology, University of Pennsylvania. May 27,
2009.
Biostatistician and Biostatistics—Today and the Future. School of Public Health, Zhejiang University. Hangzhou,
Zhejiang, P.R. China. June 1, 2010
19
PRESENTATIONS (Continued):
Series of Introduction of Biostatistics. Zhejiang University. Hangzhou, Zhejiang, P.R. China. May 24-June 2, 2010
Weibull prediction of event times in randomized clinical trials. PSI’s Pharmaceutical statistical journal club.
October 27, 2010.
Introduction to Good Biostatistics Practice. Short course Director. International Conference on Good Medical
Research. Istanbul, Turkey, March 27, 2011.
Analysis of Correlated Eye Data. ARVO short course Director and Faculty Presenter. Association for Research in
Vision and Ophthalmology Annual Meeting. Fort Lauderdale, Florida. April 30, 2011.
One Year Results of AMD comparison trials (CATT). Scheie Eye Institute Visiting Professor and Guest Lecture
Series, May 12. 2011
Validation of geographic atrophy risk score in Age-related Eye Disease Participants. 137th Scheie Eye Institute
Alumni Meeting. May 13, 2011
Prediction in Randomized Clinical Trials. International Chinese Statistics Association Applied Statistics
Symposium. Invited Speaker. June 26-28, 2011, New York City, New York.
Predictions in Clinical Trials. Roundtable Speaker. FDA/Industry Statistics Workshop. September 20, 2011.
Washington DC.
Principles and concepts in clinical trials for eye researchers. One of the Invited speaker for ARVO Clinical Trials
Course. December 2-3, 2011, Shanghai, P.R.China.
Evaluation of the medical diagnostic tests for correlated data. Invited Speaker. March 4, 2012. Omaha, Nebraska.
Baseline predictors for one year visual outcomes with Ranibizumab or Bevacizumab for Neovascular Age-related
Macular Degeneration. Association for Research in Vision and Ophthalmology Annual Meeting. Fort
Lauderdale, Florida. May 8, 2012
GRADUATE COURSES TAUGHT:
Biostatistics 659: Design of Biomedical Studies, Spring 2006. Co-taught with Dr. Heitjan.
I gave two lectures on Clinical Trial, including Randomization, Operation of multi-center randomized clinical trial,
Intent-to-Treat analysis and Data Safety Monitoring Board Meeting (DSMB)
Biostatistics 659: Design of Biomedical Studies, Spring 2007. Co-taught with Dr. Heitjan.
I gave two lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB)
meetings, and prediction of event times in randomized clinical trials.
Epidemiology 523: Inference and Linear Regression, Fall 2007.
I gave five STATA lab lectures (each lecture lasts 1.5 hours) to 12 MSCE students on how to use STATA software
for data management, data analysis, sample size/power calculations, and generating graphics.
Biostatistics 659: Design of Biomedical Studies, Spring 2008. Co-taught with Dr. Heitjan.
I gave three lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB),
and optimal prediction of enrollment duration, trial length and cost of a clinical trial.
Biostatistics 659: Design of Biomedical Studies, Spring 2009. Co-taught with Dr. Heitjan.
20
I gave three lectures on Clinical Trial, including Interim analysis plans, Data Safety Monitoring Board (DSMB),
and optimal prediction of enrollment duration, trial length and cost of a clinical trial.
Special Topics in Ophthalmology 2009-2010: A course designed to teach medical students, fellows and
junior faculties interested in vision-related research (total of about 10 attendees). The topics cover study design,
data analysis, interpretation of results, cases studies in clinical trials and epidemiology studies in
Ophthalmology. I taught 5 sessions that covers data analysis of correlated data, and prediction models.
MSCE Independent Study, Fall 2009: Co-instructor for Gil Binenbaum’s MSCE independent study project
on “The Postnatal Weight Gain Measurement for ROP Risk Stratification.” Meet weekly about 2 hours/week to
teach him on literature review of prediction model of ROP and performed the development of a prediction
model using data from a clinical trial of ROP by using SAS.
Biostatistics and Epidemiology in Ophthalmology, Fall 2010: I am director for this course, which was
designed for ophthalmology residents and fellows (total of 12+). I gave 4 hours presentation on the
“Biostatistics for conduct eye research” and one case study.
Biostatistics 659, Spring 2011: Design of Biomedical Studies, Spring 2011. Co-taught with Dr. Heitjan.
I gave two lectures (total of 4 students) on Clinical Trial, including Data monitoring in clinical trials (Interim
analysis, Data Safety Monitoring Board (DSMB)), and predictions in clinical trials.
21
Research Support
ACTIVE
U10EY017014 (Quinn)
07/01/2010 – 06/30/2014
40%
NEI/NIH
Direct cost: $8,497,054
Title: Telemedicine approaches to evaluating acute-phase ROP – e-ROP
Major goal: To evaluate the validity, reliability, feasibility, safety and relative cost-effectiveness of an ROP
telemedicine evaluation system to detect eyes of at-risk babies who meet RW-ROP criteria and therefore need
of a diagnostic evaluation by an ophthalmologist experienced in ROP.
Role: Principal Investigator for Data Coordinating Center
R01 EY021137-01A1 (Binebaum)
09/30/2012 – 09/29/2017
10%
NIH/NEI
Direct Cost: $2,500,000
Title: Postnatal growth and retinopathy of prematurity (G-ROP)
Major Goal: To develop a sensitive and specific ROP prognostic model that incorporates postnatal growth
measurements with birth weight and gestational age to greatly reduce the number of infants requiring exams in
the US.
Role: Principal Investigator for Data Coordinating Center
R21EY018908 (Ying)
08/01/09 – 07/31/13
30%
NEI/NIH
Direct cost: $275,000
Title: Analysis of data from Vision in Preschoolers (VIP) Study
Major Goal: To evaluate the validity of four best screening tools for preschool vision screening, and to examination
the vision disorders among Head Start preschoolers.
Role: Principal Investigator
2-P30-EY01583-26 (Brainard)
09/01/10 – 08/31/15
NIH/ NEI
Vision Research Center – Core Grant
To further vision research activities through provision of biostatistical support.
Role: Core Grant Director
20%
U10-EY017823 (Maguire)
09/01/06 – 07/31/13
NEI/NIH
Title: Coordinating Center for the Comparison of AMD Treatments Trials
Major Goal: To evaluate the efficacy and safety of 4 forms on anti-VEGF treatment for choroidal
neovascularization secondary to age-related macular degeneration.
Role: Senior Biostatistician
20%
R01 EY017299 (Stone)
08/01/07 - 07/31/13
20%
NEI/NIH
Title: Computer analysis of optic disc images in glaucoma.
Major Goal: Collaborate with Sarnoff laboratories to develop computer vision methods for detecting change in
optic discs in patients with glaucoma.
Role: Collaborator
USA MRMC Number: 08100002 (Doty)
07/01/09 – 06/30/13
Department of Defense
Direct cost: $4,121,115
Title: Sensory dysfunction in early Parkinson’s disease
Major Goal: To define the sensory deficits present in the early Parksinson’s disease.
Role: Co-investigator
COMPLETED
U10-EY12547 (Maguire)
09/30/00 – 09/01/06
22
5%
NIH/NEI
Coordinating Center: Vision in Preschoolers
The major goal of this project is to evaluate vision screening tests for preschool children.
Role: Senior Biostatistician
U10 EY12279 (Maguire)
12/01/06 - 11/30/08
NIH / NEI
Title: Coordinating Center for the Age-related Macular Degeneration Prevention Trial (CAPT)
Major Goal: to evaluate low intensity laser photocoagulation as a preventive treatment for the advanced
complications of age-related macular degeneration (AMD) in patients with large drusen in each eye.
Role: Senior Biostatistician
R01-EY12769 (Grunwald)
07/01/06 - 06/30/09
NEI/NIH
Title: Choroidal Circulation in Age-related Macular Degeneration
Major Goal: To evaluate the association of choroidal hemodynamics in patients with age-related macular
degeneration.
Role: Senior Biostatistician
R01 DK074151 (Grunwald)
03/01/06 - 02/28/11
NIDDK/NIH
Title: Retinopathy in Chronic Renal Insufficiency
Major Goal: To assess features of diabetic and hypertensive retinopathy as risk factors for progression of renal
and cardiovascular disease in patients with chronic renal insufficiency.
Role: Senior Biostatistician
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