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Approved April 30, 2012 DO YOU SMOKE? A NIH-funded research project is being done to learn more about how nicotine and the medication Varenicline affect the brain and behavior. Varenicline is FDA-approved for smoking cessation treatment and marketed as Chantix, a drug used to help people quit smoking. We also want to learn more about the genetic and environmental risk factors for nicotine addiction. The study requires 3 visits, 1 of which includes staying on the research unit at Johns Hopkins Hospital for 6 nights. Compensation up to $695 will be provided for study completion. For more information: IPSAR 410.502-5433 JOHNS HOPKINS MEDICINE Principal Investigator: Mary E. McCaul, PhD Protocol # NA_00031348