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In the name of God Asthma By: E. Salehifar (PharmD, BCPS) Asthma: Background At least 15 million Americans have asthma Annually cost > 12 & billion Asthma is the leading cause of lost school days in children and a common cause of lost work days among adults Mortality is rising for unknown reason After TB and HIV, Asthma had much more rise in incidence during the past 2 decades in Iran • • • • • Pulmonary diseases Obstructive diseases • Asthma – COPD (Bronchitis, Emphysema) – Restrictive diseases • Pulmonary fibrosis – Pneumonia – Khyphoscoliosis – Definition A chronic inflammatory disease that causes • recurrent episodes of wheezing, breathlessness, chest tightness, and cough particularly at night and in the early morning Airflow obstruction is reversible • The inflammation causes bronchial • hyperresponsiveness Allergens: Aeroalergenes Viruses pets Smoke Exercise Wood dust Chemicals • • • • • • • Asthma COPD Bronchitis • Emphysema • Fibrosis Overlap! Etiology Childhood-onset • Genetic predisposition for IgE-mediated • response to common aeroallergens (tree and grass pollen, pets, …) called as “Atopy” Positive family history • Adult-onset • Many adults have a negative family history and • negative skin tests Some may have nasal polyps, ASA sensitiity & • sinusitis Workplace allergens (wood dusts, chemicals) • Allergy, Asthma Pathophysiology Inflammatory cells • Eosinophils, Th2 Lymphocyte, Mast cells, – Macrophages, Neutrophis Inflamatory mediators • Leucotrienes (LTD4, LTE4), Interleukines (IL-4, – IL-5), Histamine, prostaglandines (PGD2, PGE2) Pathophysiology Pathophysiology Airway changes Symptoms Classical symptoms • Expiratory wheezing • Coughing • Dyspnea • Chest tightness or a chronic cough without • wheezing in some patients Wide variety in symptoms • Classification Symptoms Nighttime Symptoms Lung Function Step 4 Continual symptoms Frequent FEV1 or PEF ≤60% PEF variability >30% Step3 Daily symptoms >1 time/week 60%< FEV1 or PEF <80% PEF variability >30% Step 2 3-6 times/week 3-4 times/month FEV1 or PEF≥80% PEF variability 20-30% Step 1 ≤2 times/week ≤2 times/month FEV1 or PEF≥80% PEF variability <20% Classification Step 4: Severe Persistent Step 3: Moderate Persistent Step 2: Mild Persistent Step 1: Mild Intermittent Only patients in step 1 doesn't need daily medication, other – patients should receive Anti-inflammatory drugs Salbutmol (Spray) is indicated for quick relief not for – long- term control and use of salbutamol >2/week may indicate need to anti-inflammatory drugs A rescue course of systemic corticosteroid may be needed at – any time and at any step! • • • • Pulmonary Function Tests Spirometry (FEV1/FVC) • Peak expiratory flow (PEF) • ABG (pH, PO2, PCO2, HCO3, SPO2) • Spirometers Peak flow meter Spirometer Mild Obstruction Severe Obstruction Restrictive Pattern Peak flow meter Obstructive versus Restrictive Airway Disease Parameter FEV1 FVC FEV1/FVC* FEF 25%-75% Obstructive Restrictive ↓ Normal or ↓ • Normal or ↓ ↓ • ↓ Normal or ↑ • ↓ Normal, ↓, ↑ • * normal: 85% Limitations of Spirometry & Peakflowmetry Need complete patient’s corporation Are unobtainable in severely ill patients (esp. spirometry) FEV1 and PEF are relatively insensitive to small airway changes Variations in PEF • • • • Nebulizers Spacers Treatment Asthma Exacerbation • Long-Term Control • Treatment Asthma Exacerbation Salbutamol (Albuterol) (Ventolin®) – MDI+Spacer: 4-8 puffs Q 20 min up to 4 hr, then every 1-4 hr as • needed Nebulizer: 2.5-5 mg Q 20 min for 3 doses, then 2.5-10 mg Q 1-4 hr • as needed Ipratropium bromide (Atrovent®) – MDI: 4-8 puffs as needed (Should bee added to β2-agonist • therapy) Nebulizer: 0.5 mg Q 30 min for 3 doses then Q 2-4 hr as needed • Tiotropium (Spirivia) inhal cap: 18 µg – Corticosteroids (Prednisolone, Methyl – prednisolone) Prednisolone: 120-180 mg in 3-4 divided dose for 48 hr, then 60-80 • Treatment Long-Term Control Medications Corticosteroids • Inhaled C.: Beclomethasone (Becotide®), Fluticasone – (Fluoxitide®) Systemic C.: Prednisolone – Long-acting β2-agonists • Inhaled: Salmetrol (Serevent®) – Oral: Salbutamol SR – Cromolyn sodium & Nedocromil • Leucotriene modifiers (Zileuton, Zafirlucast, Montelukast) • Methylxanthines (Theophylline, Aminophylline) • Fluticasone + Salmetrole • (Seretide®) Budesonide + Formoterol • (Symbicort®) کرومولین سدیم • شروع اثر – قطره بینی ( 1 :)20mg/mlتا 2هفته – استنشاقی ( 2 :)Cap: 20 mgتا 6هفته (ورود به ریه :کمتر از )%8 • :Oralبرای systemic mastocytosisو ( IBDتایید نشده). Preferred Treatments Stage 4: Inhaled Corticosteroids (High dose ) + Salmetrol Stage 3: Inhaled Corticosteroids (Low to Med. dose ) + Salmetrol Stage 2: Inhaled Corticosteroids (Low dose) Stage 1: no daily medication needed Theophylline SR or LT modifiers are alternative for – Salmetrol in Stage 2, Cromoly or Nedocromil, Theophylline SR or LT – modifiers are alternatives Salmetrol and LT modifiers has been added for managing – young children (<5 yo) asthma • • • • Low/Mod/high Doses of Inhaled Corticosteroids Low Dose Mod. Dose High Dose Beclomethason e 42 mcg/puff 4-12 puffs 12-20 puffs > 20 puffs Fluticasone 50 mcg/puff 2-4 puffs 4-10 puffs ---------------- Fluticasone 125 mcg/puff ---------------- 2-4 puffs >4 puffs Fluticasone 250 mcg/puff ---------------- ---------------- >2 puffs Budesonide 200 mcg/puff 200-400 mcg 400-600 mcg > 600 mcg Cost Drug Beclo 50 Beclo 250 Flixotide 50 Flixotide 125 Flixotide 250 Pulmicort Seretide 50 Seretide 125 Seretide 250 Price (Rial) 40500 (200 puff) 65000 (200 puff) 160000 (120 puff) 180700 (60 puff) 335800 (60 puff) 286900 (100 dose) 250000 (120 puff) 335000 (120 puff) 466000 (120 puff) بیمه ای بودن + 58500 + + 167000 + 270000 + + + + Cost Drug Salmetrol Salmetrol (Serevent) Formoterol (Oxis) Formoterol (Foradil) Ipratopium (cipla) Ipratopium (Atrovent) Spirivia Price (Rial) 40000 226000 بیمه ای بودن + 40000 + 314300 (60dose) 217500 (30 cap) - 25500 (300 puff) + 96500 (200 puff) 25500 + 858000 (30 cap) - Patient Education Patient Education هر نفسي كه فرو میرود ممد حیات است و چون برآید مفرح ذات ،پس در هر نفسي دو نعمت موجود و بر هر نعمتي شكري واجب!