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Download Helminth derived Immunodmodulator A therapeutic for immune-related diseases Overview
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Helminth derived Immunodmodulator A therapeutic for immune-related diseases Overview The technology relates to novel compositions and methods for modulating an immune response in order to prevent or treat disease and/or conditions where T lymphocyte cells have a pathogenic role, such as Th1 or ThIL-17 mediated inflammatory conditions, chronic inflammatory conditions and autoimmune diseases Infection with Helminth parasites has been associated with immunosuppression and compromised T-cell responses. Fasciola hepatica excretory/secretory (ES) components have also been shown to suppress Th1 responses induced by a whole cell B. pertussis vaccine. Furthermore, ES component of F. hepatica stimulates the production of anti-inflammatory cytokines, such as IL-10, which can serve as potent modulators of the immune response. Advantages Applications • A method of preventing the onset and progression of autoimmune diseases, inflammatory conditions or immune mediated disorders Novel immunomodulator for T Cell mediated inflammatory and autoimmune diseases. Asthma, arthrosclerosis, Alzheimer’s disease, type 2 diabetes and osteoarthritis • Mechanism of action established through the modulation of the T cell responses which are causative of these immune mediated conditions • No recombinant or artificial anti-inflammatory agent is required, but a product that stimulates the body to make its own anti-inflammatory cytokines Market Therapeutics: Synthesis, Formulation< Processing and Drug Delivery • Cells of the innate and adaptive immune system that mediate inflammation also make these antiinflammatory cytokines in vivo, they are more likely to be effective at the site of inflammation. IP Status US patent 8,105,601 granted EP patent EP06821545.8 granted • More natural immuno-stimulatory effects would be induced as opposed to current treatments that are immune compromising, Opportunity Research collaboration and/or License • Potential immunotherapeutics that focus on resetting the balance of host regulatory to effector/pathogenic immune responses to restore homeostasis without globally suppressing the immune response Researcher(s) Technology and Patent Status Prof. Kingston Mills Development state: In research / Concept / Idea • In development / Lab scale Contact Dr. Emily Vereker, IP state: Patent(s) granted MOG induced EAE model – attenuated by Fasciola Hepatica J Immunol. 2009 Aug 1;183(3):1577-86. Case Manager, Life Sciences Clinical development phase: Target validation [email protected] The opportunity Reference: This offer is available for: further research or development support • Joint venture agreement • License agreement • Privatepublic partnership +353 1 896 4152 KM01-041-01