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Ch. 5 What do you know about your skin?: What is the branch of medicine that specializes in skin disorders? Dermatology • About what percent of body weight does the skin make up? 15-20 percent What is the skin most susceptible to? infection, disease, injury Ravaged Scarred But Repairable! What is skin? Its an organ Made of cutaneous membrane. Superficial epidermis made of stratified squamous epithelium and dense connective tissue. Length of replacement? Youth: 28-30 days, Elderly 4550 days Is skin the same thing as the integumentary system? No. Skin is a cutaneous membrane Integumentary system includes sweat and oil glands, hair, and nails. Integument= covering What is the jobs of the skin? Pg. 95 Regulates heat loss. Excretory functions for urea, salts, and water. Water Retention Manufactures proteins Synthesizes vitamin D Integrate with the nervous system for touch sensation What are the three layers of the skin? * What is the job of the epidermis? Keratinizes: becomes hard for protection Avascular: only the lowest level of the epidermis is close enough to capillaries to gain nutrients. That means: the skin you see is all dead! Shedding skin doesn’t hurt!!! Contains Melanin: pigment produced by melanocytes. Layers of the Epidermis Layers of Epidermis Stratum Basale – deepest, only epidermal cells Stratum Spinosum-make Keratinocytes Stratum Granulosum-fuse cells together Stratum Lucidum – only on hands/feet Epidermis Skin Layers Corneum Lucidum Granulosum Spinosum Basale What is the job of the dermis? Its leather. Protective, strong, living, and houses many other tissues. Sweat Glands: maintain body temp. Excrete waste. Hair follicles/bulbs: for warmth Nerves: pain, pressure, temperature Blood vessels: maintain body temp 2 Regions of Dermis Papillary layer – contain capillaries for nutrients for epidermis pain and touch receptors Regulates temperature 2 Regions of Dermis Reticular Layer – deepest skin layer Blood vessels, sweat and oil glands, and deep pressure receptors Thick collagen strengthens skin Papillary and Reticular Layers Skin Color Melanin (yellow, reddish brown, or black) Carotene Oxygen bound to hemoglobin in dermal blood vessels Poorly oxygenated blood causes cyanosis in Caucasians What do Melanocytes do? Produces pigment to protect the cells DNA. What is an appendage of the skin? Append= to hang on These are things that “hang on” or are attached to the skin. Appendages include: Glands, Hair, and Nails All appendages are part of the epidermis What is the job of hair and hair follicles? Guards the head and eyes as well as respiratory tract from particles & impact. Head Hair retains body heat. All other body hair is a vestigial feature. Hair Follicles grow hair What are the parts of the hair follicle? Pg. 96 Root of hair is enclosed in the hair follicle (The hair bulb matrix= zone of growth which contains melanin). Hair grows up the shaft to the surface of the skin. The bulk of hair is dead. There are 3 layers to hair: 1) Medulla, 2) Cortex, 3) Cuticle (Protection against abrasion, Damage=Split Ends) Hair What makes hair look different? The amount of melanin secreted The shape of the hair is regulated by the shape of the hair follicle which changes the shape of the hair shaft. Round Hair (straight shaft)= Straight and Coarse Oval Hair= Wavy and Smooth Curley Hair (hooked shaft)= Flat What are the parts of the nail? Used for protection The root of the nail is embedded in the skin. Grows from the nail matrix. The cells heavily keratinized, die. Extends along the nail bed. Lunula – moon shaped beginning of nail Fig4.7 pg. 102 Lun= moon Nail Growth What do the cutaneous glands do? Exocrine glands that secrete onto the surface of the skin. Sebaceous & Sweat Sebaceous Glands- Produce oil all over the body. Sebum used for softening, water retention, killing bacteria. Increases when testosterone is produced= Oily skin. Sweat Glands- helps maintain homeostasis What are the two types of sweat glands? Eccrine Glands: Cover Body, Contain H2O, Salt, Vit. C, Wastes, Lactic Acid pH 4-6: antibacterial Sweat pores are not easily visible, Contain nerve endings for regulation And the Other One? Apocrine glands- auxiliary and genital areas. Ducts empty into hair follicles. Milky-yellowish in color, odorless. Body odor occurs when bacteria eat it. *Thought to be used in excreting Pheromones pheromones* And Mates Why do you not have wrinkles when your young? Collagen fibers: Strong and keep the skin hydrated (attract H2O). Elastic fibers: Keep skin elastic. Like all elastic, it is less so with time. Loose fat in the hypodermis. = sagging Decrease in subcutaneous tissue, causes dryness, cold sensitivity, and bruising in the elderly. What happens when the epidermis and dermis separate? A blister Caused by friction or burns. What causes goose bumps? Smooth muscles called Arrector pili that attach to hair follicles contract. What is the job of the hypodermis? Anchors the skin Shock absorber Insulates from temperature change Gives shape to fatty areas of the body Fat Lab Time Skin Pop Quiz Brace Yourself Problems of the skin Bedsores or Decubitus Ulcers- Caused by pinching off of the blood supply to the skin. Occurs over bony areas of the body. See figure 4.4 on Pg. 98 Alopecia Fancy word for balding By age 50, 1/3 of your hair follicles may be lost Severe alopecia can happen to anyone at any age and is not thought to be genetic. ALL BODY HAIR is lost!!! Infections and Allergies of Skin Athlete’s foot (tinea pedis) – fungus More Diseases Boils and carbuncles – inflammation of hair follicles and sebaceous glands And another Disease Cold sores – herpes simplex virus – activated by emotional upset, fever or UV radiation Infections and Allergies of Skin Contact Dermatitis – itching, redness, and swelling caused by exposure to chemicals (poison ivy) Still more Disease Impetigo – pink, water-filled, raised lesions that develop a yellow crust and rupture – caused by staphylococcus Infections and Allergies of Skin Psoriasis – chronic condition of reddened epidermal lesions covered with dry scales – triggered by trauma, infection, hormones, stress Vitaligo Three possible causes Autoimmune attack Malfunctioning nerves Self destructive cells Some treatments such as creams are effective in early stages. Can effect anyone. What are the problems with smoking and sun on the epidermis? Leathery skin Cold sore (herpes outbreak) Depressed immune system All from DNA damage. Review Burns and Skin Cancer What are the ABCD’s of Skin Cancer? What are the 3deg. Of Burn? Burns Skin Cancer Link Skin Cancer Squamous Cell Basal Cell Administering Medications Transdermal - skin patches for nicotine, motion sickness, birth control – slow absorption Subcutaneous – insulin – moderate absorption Intramuscular – vaccines – rapid absorption Developmental Aspects 5th month – fetus covered with downy hair (lanugo) that is shed by birth Adolescence – skin and hair become more oily as sebaceous glands are activated (acne) Developmental Aspects Aging – hair thinning and baldness – males Gray hair – decreasing amount of melanin deposited – caused by anxiety, protein-deficiency, chemotherapy, excessive vitamin A, genetics