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Myasthenia Gravis Anastasiya Lukecha 03.06.13 Psychology 4th Name • Myasthenia Gravis • MG • Latin & Greek in origin, meaning “grave muscle weakness”. Causes • Antibodies produced by body that work against itself • Defect in the transmission of nerve impulses to muscles • Occurs when normal communication between the nerve and muscle is interrupted at the neuromuscular junction (place where nerve cells connect with the muscles they control) Target Population Affects on Brain • Electroencephalographic (EEG) abnormalities • Disturbances of brain cholinergic systems Symptoms • Very greatly among individuals • Weakness of eye muscles • Difficulty swallowing &slurred speech • Drooping of one or both eyelids • blurred or double vision • Change in facial expression • Shortness of breath • Weakness of arms, hands, fingers, legs & neck Prognosis • In most cases with treatment people can improve their muscle weaknesses and live normal lives • Sometimes severe weakness may cause respiratory failure Treatment • Physical therapy reduces muscle weakness • Anticholinesterase agents help improve neuromuscular transmission and increase muscle strength • Immunosuppressive drugs improve muscle strength by suppressing the production of abnormal antibodies • Can be expensive Notable Case • Phil Silvers (May 11, 1911 – November 1, 1985) • American entertainer and comedic actor • Starred in 1950’s sitcom “The Phil Silvers Show” played the role of sergeant Bilko • Died of heart attack Other Notable Cases • • • • • Brandon Cox David Niven Aristotle Onassis Sir Lawrence Olivier "Sleepy" of Snow White and the Seven Dwarfs was Organization • Myasthenia Gravis Foundation of America, inc. (MGFA) • “A World without MG” • The only national volunteer health agency in US dedicated to the fight against MG • Want to find a cure • Jane Ellsworth founded the foundation in 1852 when her teenage daughter Pat was diagnosed Work Cited • http://www.ninds.nih.gov/disorders/myasthenia_gravi s/detail_myasthenia_gravis.htm • http://www.ncbi.nlm.nih.gov/m/pubmed/10561522/ • http://m.free-press-release.com/news-newbreakthrough-treatment-1252615911.html • http://www.thisislewis.net/linked/famous%20people% 20diagnosed%20with%20mg.pdf • http://www.myasthenia.org/AboutMGFA.aspx
