Download Time: Monday May 2nd, 2011 5:00pm Location: Buchanan A202

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Transcript
Time: Monday May 2nd, 2011 5:00pm
Location: Buchanan A202
Modeling Cardiac Arrhythmias as Reentrant Activity in Excitable
Media
Kelly Paton, University of British Columbia
Cardiac arrhythmias such as ventricular tachycardia (VT) and fibrillation (VF)
can be fatal if left untreated. In two dimensions, these reentrant arrhythmias
can be modeled as one or more spiral waves in a system of excitable media. The
appearance of spiral waves due to structural inhomogeneities – such as damaged
tissue or scar tissue is well-studied and well-explained. However, patients can
present with VT yet have no permanent cardiac inhomogeneities. How can an
arrhythmia arise in a patient with no apparent structural defects? A potential
mechanism is the appearance of a temporarily ’deactivated’ region. I will discuss
the basic biology of the heartbeat, present the mathematical systems that are
used to model it, and show how an arrhythmia can appear in an undamaged
heart.
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