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Novel Technologies to
assess Gut Health Claims
for Carbohydrates
Lubbert Dijkhuizen & Fons Voragen
14 juni 2011
Aanleiding
• Darmgezondheid vanuit CH belangrijk en
perspectiefvol in CCC 1 en 2
• Darmgezondheid vanuit microbiota en
immuunbarriëre belangrijk en perspectiefvol in TIFN
• Interactie met Danone, aansluiting STW
Partnerprogramma
• Synergie op een strategisch gebied
Darmgezondheid in CCC
• Developing and applying approaches to determine and monitor
Carbohydrate digestibility in humans
• Lactose replacement in calf nutrition (biomarkers of insulin
resistance)
• Dietary fibre with prebiotic effects (insulin response)
• Food fibres and maintaining and improving immune barrier in the gut
• Pre- and antibiotics for a healthy colon
• New fibres: Starch/maltodextrins decorated with iso-maltooligosaccharides
• Immunomodulation by oligosaccharides
• Enzymatic modifications of prebiotics
• Optimization of enzymatic GOS production
Darmgezondheid TIFN
• In this theme biomarkers for healthy gut function will be
established and validated and the relationship between
diet, gut microbiota and maintaining the gastrointestinal
immune barrier will be investigated. The causal
relationship between gut metabolism and its microbiota
will be understood with specific attention to its influence
on weight gain and energy metabolism. Strategies are
being developed to characterise bioactive ingredients
with regard to probiotic bacteria (or bacterial cell wall
components) and dietary fibre. This theme is led by Prof.
Wim Saris.
STW-Danone Partnerprogramma
The goal of this Partnership Program is twofold:
• 1) to link different expertises and know how i.e.
immunology, neurology, endocrinology, physiology,
metabolism, (epi-) genetics to each other in order to
sustain and understand the process from ingredients to
specialized nutrition products with a health benefit.
• 2) to understand the role of the gastro-intestinal tract in
modulating neuro-immune interactions affecting
metabolic disorders, diseases and health, with the aim to
define and design the process from ingredients to
specialized products with a health benefit.
Doel en opzet van deze discussiemiddag
• Presenteren van ideeën initiatiefnemers
• Inventariseren van ideeën van geinteresseerden
• Inventariseren potentiële deelnemers met principe
commitment aan globaal beschreven onderzoeksprogramma
• Op basis hiervan preproposal maken voor eind augustus
• Opzet middag:
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Inleidingen op 4 onderscheiden thema’s
Discussies in 4 subgroepen over thema’s
Plenaire rapportage over de resultaten van discussies en synthese
Afspraken over voortgang van het proces.