Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
The Surgical Treatment of Bladder Cancer Jakko Nieuwenhuijzen This study has been performed in The Netherlands Cancer Institute / Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands. ISBN: 978-90-8659445-0 The publication of this thesis was financially supported by: Abbott, Astellas, AstraZeneca, CombiCare, Eli lilly, Eurocept, Ferring BV, GlaxoSmithKline, Hitachi, Hoogland Medical, Medisch Centrum Alkmaar, Novartis, Nycomed, Olympus, Pfizer, Pohl Boskamp, sanofi-aventis, de Vrije Universiteit, Zambon. Cover design: Gryts Lootsma Typography: Bruce Ross Printed by: Buijten & Schipperheijn VRIJE UNIVERSITEIT The Surgical Treatment of Bladder Cancer ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus prof.dr. L.M. Bouter, in het openbaar te verdedigen ten overstaan van de promotiecommissie van de faculteit der Geneeskunde op woensdag 28 april 2010 om 11.45 uur in de aula van de universiteit, De Boelelaan 1105 door Jacobus Adrianus Nieuwenhuijzen geboren te Harderwijk promotor: prof.dr. S. Horenblas Voor mijn ouders Contents Chapter 1: General introduction and outline of the thesis ............................... 9 Chapter 2: Local recurrence after cystectomy and survival of bladder cancer patients; a population based study in greater Amsterdam (J urol, 174: 97, 2005)................................................ 23 Neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin for histologically proven lymph node positive bladder cancer (J urol, 174: 80, 2005) ....................................................... 39 Small cell carcinoma of the bladder: a single centre study of 25 cases treated in analogy to small cell lung cancer (Urology, 65: 295, 2005) ............................................................... 55 Survival after bladder preservation with brachytherapy versus radical cystectomy; a single institute experience (Eur urol, 48: 239, 2005) ............................................................... 67 Salvage cystectomy after failure of interstitial radiotherapy and external beam radiotherapy for bladder cancer (BJU int, 94: 793, 2004) ................................................................ 85 Clinical outcomes after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy) in 44 patients (J urol 173: 1314, 2005; J urol 179: S35, 2008) ............................ 99 Chapter 3: Chapter 4: Chapter 5: Chapter 6: Chapter 7: Prostate sparing cystectomy: long term oncological results (BJU int, 104: 1239, 2009) ............................................................ 111 Chapter 8: Urinary diversions after cystectomy: the association of clinical factors, complications, and functional results of 4 different diversions (Eur urol 53: 834, 2008) ................................. 123 Chapter 9: Follow-up after cystectomy: regularly scheduled, risk adjusted, or symptom guided? Patterns of recurrence, relapse presentation, and survival after cystectomy (submitted) .............. 137 Chapter 10: General discussion and future perspectives ................................. 153 Chapter 11: Summary / Samenvatting.............................................................. 167 Dankwoord ............................................................................................................ 179