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Sept 13, Thursday BCSLS Telehealth Video Broadcast “THE IMPLICATIONS OF CLONAL GENOME EVOLUTION FOR CANCER MEDICINE” Costs: BCSLS members: $28, MLA, MLT Non-members: $56, Other Hospital Staff: $56 6:00 – 7:30 pm With Dr. Sam Aparicio The notion that cancers are mosaics, composed of clones of cells has been fundamental to cancer biology for several decades. Clonal evolution may underpin clinical features of cancer, such as emergence of treatment resistance, the heterogenous responses of metastatic disease within individual patients and divergence between primary and metastatic disease. Spatial and temporal variation in clonal composition poses significant challenges for diagnostic sampling and disease monitoring. The ability to monitor evolution may soon become both a research tool and important for patient monitoring. Recent developments in next generation sequencing methods have placed clonal analysis of human tumours within practical reach. I will discuss these advances and recent results from sequencing of solid tumours in the context of clonal evolution and it's impact for cancer medicine. Registration: Credit Card: Online registration www.bcsls.net – education – Telehealth Cash or Cheque: Register with the Site Coordinator at your site Where: Broadcast to over 45 sites across BC. To see which sites are participating this month, check the site list on the website. www.bcsls.net – education See it live in Vancouver at Women’s and Children’s Hospital. Limited seating.