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Investigación en Salud ISSN: 1405-7980 [email protected] Centro Universitario de Ciencias de la Salud México BASTIDAS RAMÍREZ, BLANCA ESTELA; DELGADO RIZO, VIDAL; MUÑOZ VALLE, JOSÉ FRANCISCO; GONZÁLEZ HITA, MERCEDES; RAMOS MÁRQUEZ, MARTHA ELOÍSA; CARRILLO PÉREZ, MA. DEL CARMEN Predisposición genética a daño hepático por alcohol Investigación en Salud, vol. VII, núm. 1, marzo, 2005, pp. 55-60 Centro Universitario de Ciencias de la Salud Guadalajara, México Available in: http://www.redalyc.org/articulo.oa?id=14220648009 Abstract Alcoholic liver disease (ALD) constitutes a complex and multifactorial pathophysiological condition where specific gene variation could explain the individual response to the toxic effects of alcohol. Genetic polymorphisms influencing the pathophysiology of ALD can positively or negatively regulate the transcriptional rate or the activity of molecules which contribute to the fibrogenic process. Polymorphisms in genes coding molecules underlying the signaling triggered by bacterial lipopolisacharide, LBP and CD14, which in turn activate Kupffer cells via the nuclear transcription factor NFkB, have been reported. Likewise, genetic polymorphisms in proinflamatory molecules, TNF-ALPHA, IL-1, R-IL-1, IL-6 and IL-8; growth factors, TGF-BETA and PDGF; alcohol metabolizing enzymes ADH, ALDH and CYP2E1; and in systems involved in the clearance of oxygen reactive species, like MnSOD, have been studied. Interaction between genetic variations and life-style or environmental factors, should be considered in order to elucidate the role of genetic alterations in the development of the ALD. Keywords Genes and alcohol, alcoholic liver disease, ethanol metabolyzing enzymes, polymorphisms and alcohol, candidate genes. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative
