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About XP • Xeroderma pigmentosum was first described in 1874 by Hebra and Kaposi. • In 1882, Kaposi coined the term xeroderma pigmentosum for the condition, referring to its characteristic dry, pigmented skin. Frequency • The frequency in the United States is approximately 1 case per 250,000 population. • The frequency in Europe is approximately 1 case per 250,000 population. • In Japan 1 case per 40,000 population. Race, Sex, and Age • Cases of xeroderma pigmentosum are reported in persons of all races. • An equal prevalence has been reported in males and females. • The disease is usually detected at age 1-2 years. More About XP • Xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner. It is characterized by photosensitivity, pigmentary changes, premature skin aging, and malignant tumor development. • These manifestations are due to a cellular hypersensitivity to ultraviolet (UV) radiation resulting from a defect in DNA repair. Birth • You can not detect it at or before the birth of the child, you don’t generally detect it until the child is 6 months when the first of three stages start. Symptoms • An unusually severe sunburn after a short sun exposure. The sunburn may last for several weeks. The sunburn usually occurs during a child’s first sun exposure. • development of many freckles at an early age. • Irregular dark spots. • Thin skin. • Excessive dryness. • Rough-surfaced growths, and skin cancers. • Eyes that are painfully sensitive to the sun and may easily become irritated, bloodshot, and clouded. • Blistering or freckling on minimum sun exposure. • Premature aging of skin, lips, eyes, mouth and tongue Reproduction? • Most people with xeroderma pigmentosum have normal sexual development and functioning, and they are able to have children. The probability of a person with xeroderma pigmentosum having a child with xeroderma pigmentosum is very small.