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Components of Blood
• Whole blood
– RBCs
– WBCs
– Platelets: cell fragments that aid in clotting
• Plasma
– 90% water (allows materials to dissolve)
– Amino acids, glucose, hormones, vitamins, salts, waste
– Concentrations allows diffusion in/out of blood stream
Red Blood Cells
•
•
•
•
Job: Transport O2 to cells
Produced from stem cells in bone marrow
O2 binds to hemoglobin proteins
Dead cells filtered by liver & spleen
Sickle Cell
Normal
White Blood
Cells
• Remove foreign
invaders & dead
cells
• Able to move
through body
tissue
Platelets
• Form clots when
bleeding
• Proteins form a web
to trap cells &
platelets
ABO Blood Groups
• Proteins on blood cells determine blood type
• Antigen (markers)
– proteins on cell’s surface that identify cells as foreign or
natural
• Antibodies:
– proteins from B cells to attack invaders
– Float freely in plasma
Group A blood
• A antigens on the surface of your RBCs
• B antibodies in your blood plasma
Group B blood
• B antigens on the surface of your RBCs
• A antibodies in your blood plasma
Group AB blood
• Both A and B antigens on the surface of your
RBCs
• Neither A or B antibodies in your blood plasma
Group O blood
• Neither A or B antigens on the surface of your
RBCs
• Both A and B antibodies in your blood plasma
If you have type A blood, can you receive:
Type B blood from a donor?
Type AB blood from a donor?
Type O blood from a donor?
If you have type B blood,
can you receive:
Type A blood from a donor?
Type AB blood from a
donor?
Type O blood from a donor?
If you have type AB blood,
can you receive:
Type A blood from a donor?
Type B blood from a donor?
Type O blood from a donor?
If you have type O blood, can you receive:
Type A blood from a donor?
Type B blood from a donor?
Type AB blood from a donor?
Rh Factors
• If Rh+
– Cells contain the
Rh antigen
– Can receive Rh+ or
Rh- blood
• If Rh– Cells lack the Rh
antigen
– Plasma contains
Rh antibody
– Only receive Rhblood
Francis was just in a bad accident and lost a lot of blood.
He is blood type B+. Can you help save him?
Blood type B+
Antigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
Francis has B+ blood type because
of the B and Rh antigens. If he is
given B+ blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive B+ blood?
Yes.
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given B- blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive B- blood?
Yes.
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given A+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the
A antigens.
Can he receive A+ blood?
Agglutination:
No.
clumping of the
blood
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given A- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the
A antigens.
Can he receive A- blood?
Agglutination:
No.
clumping of the
blood
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the
A antigens.
Can he receive AB+ blood?
Agglutination:
No.
clumping of the
blood
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given AB- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the
A antigens.
Can he receive AB- blood?
Agglutination:
No.
clumping of the
blood
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given O+ blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive O+ blood?
Yes.
Vein
Francis has B+ blood type because
of the B and Rh antigens. If he is
given O- blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive O- blood?
Yes.
Vein
Sebastian was just involved in an accident at work and
lost a lot of blood. He is blood type A-. Can you help
save him?
Blood type AAntigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
Sebastian has A- blood type
because of the A antigen. If he is
given A- blood in a transfusion…
Will his antibodies attack this blood?
No. His B and Rh antibodies only
attack B and Rh antigens.
Can he receive A- blood?
Yes.
Vein
Sebastian has A- blood type
because of the A antigen. If he is
given A+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His Rh antibodies will attack
the donated Rh antigens.
Can he receive A+ blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given B- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His B antibodies will attack the
donated B antigens.
Can he receive B- blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given B+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. Both his B and Rh antibodies will
attack the donated B an Rh antigens.
Can he receive B+ blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given AB- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His B antibodies will attack the
donated B antigens.
Can he receive AB- blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. Both his B and Rh antibodies will
attack the donated B and Rh antigens.
Can he receive AB+ blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given O+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His Rh antibodies will attack
the donated Rh antigens.
Can he receive O+ blood?
No.
Vein
Agglutination:
clumping of the
blood
Sebastian has A- blood type
because of the A antigen. If he is
given O- blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A
antigens.
Can he receive O- blood?
Yes.
Vein
Blood type AB+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type O+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type ABAntigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type B+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type OAntigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
1) Can this work?
• Acceptor
• Donor
O-
AB-
2) Can this work?
• Acceptor
• Donor
A+
A-
3) Can this work?
• Acceptor
• Donor
AB-
B-
Kobe Kuiz
1)
2)
3)
4)
5)
6)
What are the components found inside blood?
What are the ingredients of plasma?
What is the purpose/function of RBCs?
Which part of blood stop bleeding when cut?
What do antibodies bind with?
If a person has type AB-, which antigens do they possess?
Which antibodies?
7) If a person has type O+, which antigens do they possess?
Which antibodies?
8) If a person is type A-, list all the blood types this person can
receive in a transfusion.
9) If a person is type O-, list all the blood types this person can
receive in a transfusion.