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Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation protein function phenotype organism amino acid sequence The Ames Test Reveals Mutagenic Compounds Strain 1 - frameshift mutation Strain 2 - base substitution Ames Test Results1 Revertant colonies per culture plate. Treatment Control diethyl sulfate* ICR-191** TA1575 TA1578 11 25 14,700 0 13 450 TA1575 : his base substitution mutant TA1578 : his frameshift mutant * ** Highly toxic alkylating agent, occurs as colorless liquid with peppermint odor Acridine, colorless solid intercalating agent, known carcinogen 1 McCann et al., 1975. Proc. Natl. Acad. Sci. USA 72 979-983. Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation protein function phenotype organism amino acid sequence Diploid Life Cycle vs. Haploid Life Cycle
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