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Transcript
Sedative-Hypnotics
Benzodiazepines
Megan Trimble
Doctor of Pharmacy Candidate
April 2006
1
What are Sedative-Hypnotics?
Tranquilizers may be a more familiar term
used to describe sedative-hypnotic agents
(1)
– “Downer drugs”
Drugs that take the edge off
– Calm your mood when you are feeling
anxious
– Induce sleep (1)
2
Benzodiazepines
Most frequent class of
drugs that have a
tranquilizing-type effect
Prescription drugs (1)
http://www.drugfree.org/Portal/Drug_Guide/Prescription%20Sedatives%20Tranquilizers (2)
3
Taking the Drugs
This class of drugs is fairly safe when
taken for their intended use and not used
in excess (1)
Most sedatives come in capsules or
tablets
– Multi-colored
Liquid and injection forms are also
available (2)
4
Taking the Drugs
The use of benzodiazepines can lead to
abuse, whether they are taken properly or
for the wrong reasons
http://www.drugfree.org/Portal/DrugIssue/Features/Prescription_Medicine_Misuse Accessed May 2, 2006.
5
Prescription Benzodiazepines
Chlordiazepoxide (Librium)
Diazepam (Valium)
Temazepam (Restoril)
Triazolam (Halcion)
Clonazepam (Klonopin)
Lorazepam (Ativan)
Alprazolam (Xanax) (1,3)
6
Why Do People Use
Benzodiazepines?
Reduce anxiety levels
– Helps people to cope with stress (1)
Trouble sleeping
In combination with amphetamine-like
drugs
– Many people use sedatives to calm
themselves back down from the rush
associated with amphetamine use
7
Why Do People Use
Benzodiazepines?
To get away from
this!
http://images.google.com/imgres?imgurl=http://www.long-island-hypnotherapy.com/images/anxiety Accessed May 2, 2006.
8
Short-Term Effects
(Low Doses)
Euphoria
– “Being in a happy world”
Fatigue
– Feeling drowsy
Shallow breathing
– Not being able to take full, deep, normal
breaths (2)
Trouble coordinating your movements
9
Short-Term Effects
(High Doses)
Paranoia
– Having an unrealistic perception of
something, someone, or some place in
relationship to the world and you
Aggression
Easily agitated
Difficulty remembering
Irritability (2)
10
Effects in Overdose
Unconsciousness
Respiratory depression
Collapse of heart and heart functions
Walking difficulty
CNS depression
Shallow breathing
– Not being able to take full, deep, normal
breaths (1,2)
11
Long-term Effects
“Rebound effects”
– Over use of these drugs can cause a reversal effect
– Seizures can occur; calm and relaxed feelings dissipate
Tolerance develops, resulting in dependence
– Must have more and more of the drug to feel an even minor
effects
– Higher risk of overdose
Withdrawal
– This leads to dependence as well
– No one wants to feel the unpleasant withdrawal effects, so
continues use (2)
12
Cognitive Effects
Memory impairment/Amnesia
Confusion
Sleepiness (1)
http://images.google.com/images?svnum=10&hl=en&lr=&q=cognitive Accessed May 2, 2006.
http://images.google.com/images?svnum=10&hl=en&lr=&q=sleeping+cartoon Accessed May 2, 2006.
13
Psychological Effects
Relaxation
– Helps with the daily stresses of life/relieves tension
– Anxiety from school and peer stresses
Drowsy
– Easier to sleep/induces sleep (1,2)
Distracts you from other problems going on
around you and in your own life
– Just a temporary fix; the problem never goes away
14
Benzodiazepine Pharmacology
CNS Depressant (1)
– The major action of the benzodiazepine drug
class is focused in the brain
– Can cross the blood brain barrier (BBB)
Easy access to the brain where the drugs exert
their effect
Affects other body systems as well
– Heart
Acts on different sites (receptors) of the heart (1)
15
Benzodiazepine Pharmacology
Benzodiazepines act
on the GABA system in
the brain
– Increase function (1)
http://www.stayinginshape.com/3chsbuffalo/libv/m02.shtml Accessed May 2, 2006.
16
Duration of Benzodiazepines
These prescription drugs are long acting
Even after the effects wear off, the drug is
still in your system for a long period of time
– Hours
– Days
– Weeks
During this lengthy period of time, these drugs will
show up in blood tests and drug screens (1, 2)
17
Danger: Caution
It is extremely dangerous to use these
drugs in combination with alcohol
– Since these drugs stay in your
body for a long period of time, drinking
can effect your body even when you
are not feeling the effects of the sedative
type drug.
Slowed breathing/decrease lung function
Decrease heart rate (1,2)
http://images.google.com/images?q=alcohol&hl=en Accessed May 2, 2006.
18
Caution: Overdosing
Due to the tolerance that develops with
benzodiazepines and the lengthy duration
in the body, overdosing can have an “all of
a sudden” effect
– Overdose symptoms may not be felt until 1236 hours after overdose has already occurred
(1,2)
http://images.google.com/images?svnum=10&hl=en&lr=&q=overdosing Accessed May 2, 2006.
19
Withdrawal Symptoms
Tachycardia – increase in heart rate
Severe headaches
Panic attacks can occur
Tremors
Changes in perception – not fully in tune with, or
aware of, everything going on around you
Weight loss
Parasthesias
– Pins and needles/tingling feeling (1)
20
Summary
Benzodiazepines is a class of drugs that have an effect
on the brain that, in turn, induces sleep and causes
feelings of relief, relaxation and a state of euphoria.
Benzodiazepines should only be taken as prescribed by
your physician. Although this class of drugs is one of the
safest classes of prescription drugs, consuming these
drugs should not be taken lightly. If anything, greater
caution should be taken.
Although the initial and intended feelings from use are
almost always addicting. Continuing and exceeding use
for this reason can only lead to trouble. Respiratory,
heart and psychological problems can occur, as well as
withdrawal, overdosing and even death.
21
References
(1) Goldfrank’s Toxicologic Emergencies. 7th ed. c2002. The McGraw-Hill
Companies, Inc. “Chapter 63 Sedative-Hypnotic Agents” April 10th 2006
[Date accessed]. Available from STAT!Ref [database on the Internet]
(2) “Prescription Sedatives and Tranquilizers.” [about 2 screens] The
Partnership for a Drug-Free America. [Internet Website] c2006. Partnership
for a Drug-Free America. [in association with] 10 April 2006 [date accessed]
<http://www.drugfree.org/Portal/Drug_Guide/Prescription%20Sedatives%20
Tranquilizers>
(3) Drug facts and comparisons. St. Louis: Facts and Comparisons, c2005
[cited 2006 May 1]. Diazepam; [about 7 screens]. Available from: Facts &
Comparisons 4.0 [proprietary database on in Internet].
22