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ESM technology: enhancing drug performance • Neutral molecules pass freely through cell • Pharmacokinetics limited by clearance from plasma Intracellular target “Parent” molecule ESM technology: enhancing drug performance • Linking motif to parent creates novel IP • Neutral parent/motif is cell permeable Intracellular target ESM technology: enhancing drug performance • Linking motif to parent creates novel IP • Neutral parent/motif is cell permeable ± Intracellular target • Motif cleaved by intracellular enzyme leaving charged species • Family of three enzymes • Charged species also novel/patentable • Expression of one is restricted to macrophages • Charged species accumulates in cell Back
