Download Multiple Dermatofibromas

Multiple Dermatofibromas
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The epidermis exhibits regular hyperplasia and increased basal layer
pigmentation. In the dermis, there is a spindle cell proliferation composed of cells with tapered
ends, small nuclei and vacuolated cytoplasm-arranged in fascicles and merging with the
surrounding connective tissue. Masson trichrome: fibrous tumor. Alcian blue, iron, vimentin
stains: positive. Desmin & S100 stains: negative.
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Dermatofibroma (DF) commonly occurs as a solitary lesion over lower extremities, more
frequently in women than men. Multiple dermatofibromas have been reported in association with
systemic diseases mainly immunosuppression, autoimmune diseases, pregnancy, hyperlipidemia,
diabetes and kidney disease. It is suggested that DF represents the outcome of an abortive
immune response to an unidentified antigenic stimulus such as insect saliva, trauma….leading to
an inflammatory proliferation of dermal dendritic cells.
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-Sharata H, Hashimoto K, Fernandez-Madrid F. Multiple hyperpigmented nodules. Multiple
dermatofibromas in a patient with systemic lupus erythematous. Arch Dermatol 1994; 130: 650l, 653.
-Ammirati CT, Mann C, Hornstra IK. Multiple eruptive dermatofibromas in three men with HIV
infection. Dermatology 1997; 195: 344-8.
- Nestle FO, Nickoloff BJ, Burg G. Dermatofibroma: an abortive immunoreactive process
mediated by dermal dendritic cells? Dermatology 1995;190:265-8.
-YamamotoT, Katayama I, Nishioka K. Involvement of basic fibroblast growth factor in
fibroblast-stimulatory serum activity of a patient with systemic lupus erythematosus and multiple
dermatofibromas. Dermatology 1995; 191; 281 – 5.