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Development and Implementation of an Anesthesia-Led Multidisciplinary High Risk Surgical Committee at a Specialty Cancer Hospital Use of a High Risk Surgical Committee may improve the perioperative course of the complex multi-morbid patient being considered for major cancer surgery. Case Summary 67yo woman with clear cell CA for open radical nephrectomy. PMHx: COPD (FEV1 of 22%, incalculable DLCO, ambulatory desaturations while on oxygen), poor functional status, medication non-compliance and continued smoking. 52yo woman with muscle invasive bladder cancer for robotic cystectomy with anterior pelvic exoneration. PMHx: moyamoya disease with recent CVA now status-post ECIC bypass, recent NSTEMI due to hematuria while on dual antiplatelet therapy, DM, chronic pain and seizure disorder. HRC Findings and Recommendations -Surgery is preferred therapy but not urgent and pt would benefit from optimization. -Recommend sustained medication compliance, complete smoking cessation and 6 weeks of pulmonary rehabilitation followed by pulmonology re-evaluation. -If able to demonstrate significant improvement in her pulmonary function patient will be reconsidered for the OR. -Cystectomy is treatment of choice. Repeat bout of significant hematuria may be life threatening. Not risk prohibitive if patient agrees with proceeding at elevated risk. -Neurosurgery, cardiology and surgeon agree with proceeding on ASA 81mg, strict hemodynamic goals and intra-operative neuromonitoring. -ICU, intra-operative monitoring and analgesic plan discussed. -Advanced directives and proxy prior to OR. 80yo male with 2nd recurrence of invasive SCC of the oropharynx with pharyngocutaneous fistula scheduled for pharyngo-esophagectomy, left carotid endarterectomy, gastric pullup and reconstruction (2 day procedure). Outcome -8 months later FEV1 33% with improved functional capacity. -Reconvened HRC suggests minimally invasive procedure. -Surgery performed with uncomplicated 5 day postop course. -Advanced directives completed. -Pt to OR with uneventful intra-operative course. -Discharged home in stable condition on postoperative day 10. -Risk-benefit ratio discussion highlighted that the -Procedure cancelled. procedure was unlikely to be curative, only -Patient referred to palliative care. palliative to aid with secretions and tolerating oral diet. -Significant risks included (among other things) a very high possibility of perioperative CVA and death. PMHx: SCCs status-post laryngectomy -Given advanced age and multiple comorbidities, and radiation, HTN, CAD, aortic stenosis recommendation made to not proceed with and a history of TIAs. surgery. -Referred to palliative care for symptom control. Total Patients Average Age ASA 3 to 4 Ratio Avg NSQIP Risk of Serious Complication Avg NSQIP Risk of Any Complication Avg NSQIP Risk of Pneumonia Avg NSQIP Risk of Cardiac Complication Avg NSQIP Risk of Wound Infection Avg NSQIP Risk of UTI Avg NSQIP Risk of Blood Clot Avg NSQIP Risk of Kidney Failure Avg NSQIP Risk of Return to OR Avg NSQIP Risk of Discharge to Rehab Avg NSQIP Risk of Mortality SURGERY SURGERY NOT PERFORMED PERFORMED 57 47 71 73 43 to 14 25 to 19 17% 22% 25% 29% 4% 6% 2% 3% 8% 7% 4% 5% 2% 2% 2% 3% 6% 7% 13% 22% 3% 4% Roswell Park Cancer Institute is a NCI designated comprehensive cancer treatment center located in Buffalo, NY. As the region’s only such institution, we frequently evaluate medically complex patients for major cancer surgery. In 2014 our Department of Anesthesia developed and implemented a High Risk Surgical Committee (HRC) to better evaluate, optimize and plan for the perioperative course of these challenging patients. Methods: All surgical patients are evaluated by the Anesthesia Perioperative Evaluation Clinic. Criteria for requesting HRC review non-specific and liberal. Anyone may request HRC review. The policy suggests that consideration be given to cases deemed high risk by objective measure, patients with advanced systemic disease (especially poorly controlled disease), patients of advanced age and/or with limited functional capacity, the frail and patients in whom surgical risk may outweigh potential benefit. The NSQIP risk calculator is commonly employed by APEC as our screening tool of choice. Standard HRC composition includes: surgeon specific to the case, the Chair of Surgical Oncology, an anesthesiologist, Director of APEC, Critical Care MD, Risk Management, Palliative Care and consultants as indicated. The meeting format has been standardized. It begins with a brief case review by the surgical team. Additional pertinent information is then provided by the anesthesia team or consultants. NSQIP risk calculator information is included whenever possible. Other surgical service specific risk estimations are discussed when available. Once all of the relevant information has been presented, a risk-benefit discussion ensues with the goal of answering, “Is this case risk prohibitive?” In some more information or work-up is necessary. If the case is deemed risk prohibitive, HRC may make recommendations on alternative non-surgical options. If the case is deemed to be “not risk prohibitive”, the discussion moves towards optimizing the patient’s perioperative course. This may include: additional testing or subspecialist clearances prior to the surgery, perioperative medication management, prehabilitation, addressing Advanced Directives, recommendations regarding the procedure (open vs. minimally invasive, downgrading to a lesser procedure), anesthetic management (general vs. regional), fluid management, ventilation strategies, post-op pain control, recommended intra-operative access/monitoring, pre-emptive planning for possible case-specific complications, post-operative disposition and more. A summary of the discussion is documented in the medical record. Lessons Learned • A HRC can be successfully developed and implemented at a specialty cancer institution. • Use of a HRC can lead to a more thorough multidisciplinary evaluation of a candidate for major cancer surgery as well as improve communication and planning among multiple providers involved in all phases of the patient’s perioperative care. • Outcomes data to evaluate the impact of the model is needed. Dr. Raymond D. Sroka MD, PharmD; Dr. Timothy D. Quinn MD; Dr. Thomas Croucher MD; Dr. Ian Cohen MD, FCCP, FCCM, CLSSBB; Ruth Renner JD, CLSSBB. Roswell Park Cancer Institute Department of Anesthesiology, Critical Care and Pain Medicine Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo