Download Session B - American Association for Cancer Research

Fourth AACR International Conference on
FRONTIERS IN BASIC CANCER RESEARCH
October 23-26, 2015 • Philadelphia, PA
Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m.
Cancer Stem Cells and/or Tumor Dormancy
B01
Cyclin D1 integrates G9a-mediated histone methylation and nuclear lamina association with
lamina-associated domains. Zhiping Li, Xuanmao Jiao, Mathew C Casimiro, Sanjay Katiyar, Ke Chen,
Xiaoming Ju, Adam Ertel, Debra Klopfenstein, Aydin Tozeren, Richard Pestell.
Tumor Microenvironment and/or Inflammation
B02
Honokiol attenuates stemness, growth and metastasis of pancreatic tumor cells: A novel
natural agent for therapy and prevention. Courey A Averett, Arun Bhardwaj, Sumit Arora, Sanjeev
Srivastava, Seema Singh, JE Carter, Ajay P Singh.
B03
HURP and ZEB1: Novel prognostic biomarkers in colorectal carcinomas. Logan Fair, Ingrid
Espinoza, Xu Zhang, Abdelouahid Elkhattouti, Tangeng Ma, Joy King, Elizabeth Tarsi, Richard Whitlock, Vijay
Kannuthurai, Ryan Jimenez, Tara Craft, Mary Graichen, Sharon Lobert, Roy Duhe, Charulochana Subramony,
Christian R Gomez, Christopher Lahr.
B04
A role for EphA3 in angiogenesis in vivo and in vitro exploration. Rae H Farnsworth, Mary E
Vail, Magdaline Costa, Linda Hii, Ross A Dickins, Andrew G Elefanty, Edouard G Stanley, Martin Lackmann.
B05
Invadopodium formation is enriched in perivascular niches and leads to cancer cell
intravasation. Aviv Bergman, John Condeelis, Bojana Gligorijevic.
B06
Cancer associated fibroblasts in the activated stroma and their interaction between ERM
proteins in breast cancer progression. Sreelatha Krishnakumar Hemalatha, Arun Peter Mathew, Thara
Somanathan, Jithin Dev, Reshma R S, Satheesh Kumar S, Revathy Nadhan, Priya Srinivas.
B07
Tumor promoting activity of SLC13A3 in metastatic prostate cells. Aigul Zhunussova, Zhanar
Irgebayeva, Bhaswati Sen, Leah Friedman, Saniya Ossikbayeva, Sultan Tuleukhanov, Ari Brooks, Richard
Sensenig, Zulfiya Orynbayeva.
B08
Inflammasome components caspase-1, IL1β, IL18 and NLRP3 (NOD-like receptor family, pyrin
domain containing 3) are increased in a spontaneous model (chicken: Gallus gallus) of human ovarian
cancer. Judith Luborsky, Seara Edassery, Seby L Edassery, Animesh Barua, Janice M Bahr.
B09
Differential effect of microenvironment on tumor phenotype using an immature T cell
lymphoma mouse model. Philip J Lucas, Ronald E Gress.
B10
Cyclin D1 restrains oncogene-induced autophagy via phosphorylation of LKB1. Mathew
Casimiro, Gabriele Di Sante, Emanuele Loro, Timothy Pestell, Sara Bisetto, Marco Velasco-Velázquez,
Xuanmao Jiao, Zhiping Li, Chenguang Wang, Daniel Ly, Bin Zheng, Shen Che-Hung, Adam Ertel, Richard G
Pestell.
B11
Characterization of human effectors in the tumor microenvironment of NSCLC patients and
lung tumor xenograft models. Hyun-Jeong Ra, Gisela Brake-Silla, Evgeniy Eruslanov, Michael Sharp,
Charuhas Deshpande, Michael D Feldman, Amy Ziober, Li-Ping Wang, Manuel A Sepulveda, Linda A Snyder,
Gwenn Danet-Desnoyers.
B12
Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in
cancer. Lalita A Shevde, Kyle Adam Morrow, Shamik Das, Rajeev S Samant.
Fourth AACR International Conference on
FRONTIERS IN BASIC CANCER RESEARCH
October 23-26, 2015 • Philadelphia, PA
Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m.
Technologies Used in Basic Cancer Research
B13
In vitro animal cancer model for assessment of sulfated polysaccharides extract of Ulva
lactuca as colon cancer therapeutic and chemopreventive agents. Marwa Abu-Serie, Maha El
Demellawy, Mohamed El-Sayed, Fatma El-Rashidy.
B14
Nanoparticles as potential therapeutic treatments for Inflammatory breast cancer (IBC) by
disassociation of emboli formation. Arun Kumar, Sangjucta Barkataki, Kenneth L. van Golen.
B15
Morphologically compatible mass spectrometric analysis of lipids in cytological
specimens. Aparna Baxi, Mariam ElNaggar, Christopher Umbricht, Alfred L Yergey, William Clarke, Matthew
T Olson.
B16
High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with
CRISPR-Cas9 screens. Traver Hart, Megha Chandrashekhar, Michael Aregger, Zachary Steinhart, Kevin R
Brown, Graham Macleod, Monika Mis, Michal Zimmermann, Amelie Fradet-Turcotte, Song Sun, Peter Driks,
Sachdev Sidhu, Frederick P Roth, Olivia S Rissland, Daniel Durocher, Stephane Angers, Jason Moffat.
B17
Role of Sall2 transcription factor under genotoxic stress: A transcriptomic approach.. Carlos A
Farkas, Francisco Fuentes, Boris Rebolledo, Kateryna Makova, Anton Nekrutenko, Ariel Castro, Roxana
Pincheira.
B18
A simple method to prepare oligonucleotide-conjugated antibodies for multiplex protein
detection. Haibiao Gong, Ilona Holcomb, Aik Ooi, Xiaohui Wang, Daniel Majonis, Marc Unger, Ramesh
Ramakrishnan.
B19
Functional analysis of oncogenic driver mutations in human cancer cells through CRISPRbarcoding. Alexis Guernet, Dorthe Cartier, Sathish Kumar Mungamuri, Sahil Adriouch, Myriam Vezain,
Françoise Charbonnier, Sophie Coutant, Shen Yao, Hassan Ainani, David Alexandre, Olivier Boyer, Stuart A
Aaronson, Youssef Anouar, Luca Grumolato.
B20
Single-cell profiling of EGFR-regulated protein changes involved in cell cycle, cell proliferation
and apoptosis. Ilona Holcomb, Gajalakshmi Dakshinamoorthy, Benjamin Liu, Marc Unger, Ramesh
Ramakrishnan, Haibiao Gong.
B21
Using computational modeling to quantify targeted agent binding and internalization in
pancreatic cancers.. Aleksandra Karolak, Veronica Estrella, Tingan Chen, Amanda Huynh, David Morse,
Katarzyna Rejniak.
B22
Screening and validation of combination therapy in T cell leukemia. Marsilius Mues, Marthe F
Lindenbergh, Michael T McManus, Jeroen P Roose.
B23
Chemoproteomic profiling of native kinases during the treatment of cells with kinase
inhibitors. Tyzoon K Nomanbhoy, Heidi E Brown, Jiangyue Wu, Subha Vogeti, Arwin Aban, Wendy Grant,
Alemayehu Senait, Shuzhen Wu , Christa Dias, Geeta Sharma.
B24
The diagnostic power of direct mRNA profiling in breast cancer core biopsy. Indira Prabakaran,
Paul J Zhang, Marina Guvakova.
Fourth AACR International Conference on
FRONTIERS IN BASIC CANCER RESEARCH
October 23-26, 2015 • Philadelphia, PA
Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m.
Mechanisms of Resistance
B25
Anti-Mullerian hormone (AMH) supports epithelial identity and survival signaling in lung
cancer. Tim N Beck, Vladislav Korobeynikov, Alexander Kudinov, Rachel Georgeopoulos, Emmanuelle
Nicolas, Margret B Einarson, Yan Zhou, Yanis Boumber, David A Proia, Ilya G Serebriiskii, Erica A Golemis.
B26
S6 kinase constitutes a vulnerability in NRAS mutant melanoma. Hsin-Yi Chen, Patricia ReyesUribe, Minu Samanta, Jessie Villanueva.
B27
Involvement of c-MET signaling in BCRP/ABCG2 activation and resistance to doxorubicin and
photodynamic therapy. Bo-hyun Choi, Kyeong-Ah Jung, Mi-Kyoung Kwak.
B28
Mitogen-activated protein kinase-driven Sprouty2 expression mediates resistance to receptor
tyrosine kinase-targeted therapeutics in glioblastoma cells. Evan K Day, Matthew J Lazzara.
B29
Characterization of the regulatory feedback program components after HER2 inhibition in
breast cancer cells. Nareeza Sakur, Marc Fink.
B30
Stress granules integrate KRas-driven cell intrinsic and extrinsic signals to determine tumor
drug response. Elda Grabocka, Commisso Cosimo, Yuliya Pylayeva-Gupta, Dafna Bar-Sagi.
B31
Establishment of a 5-fluorouracil-resistant esophageal squamous cell carcinoma cells with
dihydropyrimidine dehydrogenase gene amplification. Osamu Kikuchi, Kiichiro Baba, Shinya Ohashi,
Manabu Muto.
B32
Single-cell non-genetic heterogeneity confers drug resistance in melanoma. Sydney M Shaffer,
Andrew G Biaesch, Stefan Torborg, Clemens Krepler, Meenhard Herlyn, Arjun Raj.
Drug Development and New Therapeutic Modalities
B33
The oligoclonal antibody MM-151 overcomes acquired resistance to cetuximab and
panitumumab in colorectal cancer cells harboring EGFR extracellular domain mutations. Sabrina
Arena, Giulia Siravegna, Benedetta Mussolin, Jeffrey D Kearns, Beni B Wolf, Sandra Misale, Luca Lazzari,
Andrea Bertotti, Livio Trusolino, Alex Adjei, Clara Montagut, Federica Di Nicolantonio, Rachel Nering, Alberto
Bardelli.
B34
Quantitative systems pharmacology and immunotherapy: accelerating lead generation and
optimization of a PD-1 x TIM-3 biotherapeutic in immuno-oncology. Joshua F Apgar, Jamie Wong, Ryan
Phennicie, Mike Briskin, John M Burke.
B35
Prevention of colitis-associated colorectal cancer by a novel polypharmacological HDAC
inhibitor. Tzu-Tang Wei, Yi-Ting Lin, Ching-Chow Chen.
B36
Orally active low molecular weight heparin conjugates as a tumoral lymphangiogenesis
inhibitor. Jeong Uk Choi, Youngro Byun.
B37
Anti-PD-L1 activity of Nano-diamino-tetrac (Nanotetrac) on cancer cells. Yu-Tang Chin, HsuanYu Lai, Heng-Yuan Tang, Hung-Yun Lin, Shaker A Mousa, Paul J Davis.
B38
A Novel (+)-dehydroabietylamine derivative shows activity against triple-negative breast
cancer cells. Lekh Nath Sharma Gautam, Taotao Ling, Fatima Rivas.
B39
Inhibition of the oncoprotein FUBP1 by SN-38 represents a novel therapeutic option for the
treatment of hepatocellular carcinoma. Stefanie Hauck, Sabrina Khageh Hosseini, Josephine Wesely,
Dieter Steinhilber, Jörg Schulze, Annabelle Vogt, Maria Gonzalez-Carmona, Christian Strassburg, Stefan
Zeuzem, Thomas Vogl, Jörg Trojan, Stephan Zangos, Ricardo Biondi, Eugen Proschak, Martin Zörnig.
Fourth AACR International Conference on
FRONTIERS IN BASIC CANCER RESEARCH
October 23-26, 2015 • Philadelphia, PA
Poster Session B – Sunday, October 25, 4:45 p.m.-7:00 p.m.
B40
Tuning exosomes to modulate macrophage inflammation: A therapeutic strategy for
melanoma. Thomas A Noel, Joshua L Hood.
B41
Specific blocking of miR-17-5p guide strand in triple negative breast cancer cells, without
amplifying passenger strand activity. Yuan-Yuan Jin, Eric Wickstrom.
B42
The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast
cancer. Mehran Makvandi, Estifanos D Tilahun, Brian P Lieberman, Kuiying Xu, Chenbo Zeng, Catherine Hou,
Robert H Mach.
B43
Quantitative PCR and in-situ-hybridization analysis to determine tissue concentration and
localization of MRX34. Desiree Martin, Kevin Kelnar, Andreas G. Bader.
B44
Sulfated fucan inhibits tumor interaction with endothelial cells and tumor growth: Possible
contribution of an anti-vascular endothelial growth factor (VEGF) neutralizing activity. Viviane
Mignone, Camila Castro Figueiredo, Aline Oliveira, Eliene Kozlowski, Lubor Borsig, Mauro Pavão, Paulo
Mourão, Veronica Morandi.
B45
Piptandenia africana and Nauclea latifolia protect against N -Nitrosodiethylamine induced
hepatic tumors in Wistar rats. Queen-Esther E Akinade, Sarah O Nwozo, Olubunmi A Akinwumi, Owumi E
Solomon.
B46
Rac1 inhibition as a therapeutic strategy in breast cancer. Dana Senderoff, Georges Azzi, Erik
Goka, Marc Lippman.
B47
A novel mechanism for field-controlled high-specificity targeted anticancer drug delivery and
on-demand release using magnetoelectric nanoparticles. Alexandra Rodzinski, Ali Hadjikhani, Tiffanie
Stewart, Emmanuel Stimphil, Rakesh Guduru, Ping Liang, Carolyn Runowicz, Sakhrat Khizroev.