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Parathyroid Hormone Forteo (Teriparatide) Reclast OR Zometa (Zolendronic Acid) Bisphosphonate Calcitonin Bisphosphonate Aredia (Pamidronate) Miacalcin Bisphosphonate Boniva (Ibandronate) SERM Spine & Hip Cortical (surface) Bone Bisphosphonate Actonel (Risedronate) Evista (Raloxifene) Spine & Hip Cortical (surface) Bone Bisphosphonate Fosamax (Alendronate) Spine & Non-vertebral Sites in Cortical & Trabecular (inner/structural) Bone Spine Cortical (surface) Bone Mostly Spine Cortical (surface) Bone Spine Cortical (surface) Bone Spine & Hip Cortical (surface) Bone Spine & Hip Cortical (surface) Bone Type of Drug Drug Type of Bone Showing Increase of BMD/Reduction of Fracture Risk ■ Increases Osteoblast (Bone Building Cells) ■ ■ ■ ■ ■ ■ ■ Suppresses Osteoclast (Bone Break Down) Available in weekly dose or once a month Available in weekly dose, Liquid form or w/ Vitamin D Misc. Info. Reclast / Zometa--IV Infusion 1 time per year. Must take calcium and Vitamin D following infusions Reclast Approved / Zometa Not FDA Approved for Treatment Of Osteoporosis Daily Subcutaneous injection, 2 year limit Nasal spray, must be kept refrigerated S/Forms/DEXA/Comparing bone Strengtheners.xls Revised 01-01-2008 Page 1 of 1 High Risk Men and Women Treatment for Post-Menopausal Women Only Treatment for Post-Menopausal Sometimes confused w/ HRT, Women Only yet is NON-Hormonal IV Infusion 1 time every 3 months Not FDA Approved for Treatment Of Osteoporosis Prevention & Treatment in Men Available in monthly dose or IV and Women Push every 3 mo. Prevention & Treatment in Men and Women Prevention & Treatment in Men and Women Approved For Comparing Brand-Name Bone Strengtheners