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IMIPENM + CILASTATIN Usual Diluents NS. Reconstitution Prior to use, dilute dose into 100-250 mL of an appropriate solution. Imipenem is inactivated at acidic or alkaline pH. Final concentration should not exceed 5 mg/mL. Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate] [0 to 500 mg] [100 ml] [30 min] [up to 1 gram] [250 ml] [60 min] Stability / Miscellaneous Imipenem/cilastatin powder for injection should be stored at <25°C (77°F). Reconstituted I.V. solutions are stable for 4 hours at room temperature and 24 hours when refrigerated. Do not freeze.
