Download Pharmacokinetics of Fenbendazole Suspension and Amoxicillin

Michelle Hervey
Pharmacology and Pharmacy
VETE 4305
02/01/2015
Scrappy is a 6 year old, N/M, Australian Shepherd who
has presented to the clinic with hematochezia for the
passed couple of days. The patient is eating, and
drinking normally. Upon fecal floatation Trichuris
vulpis was for identified on the slide.
http://www.haustierratgeber.de/hunde/ras
sen/australian-shepherd/
http://server.ugent.be/groups/parasites
pics/wiki/3debb/Trichuris_vulpis.html
Fenbendazole Suspension
http://www.msd-animalhealth.co.uk/products_public/panacur_10
__liquid/overview.aspx
Amoxacillin Suspension
http://store.mcguff.com/products/38
55.aspx
•
This drug is only marginally
absorbed after administered orally
(Plumb 2011).
• Amount absorbed in the gut
depends on the solubility of the
drug, not the dose given (Plumb
2011).
• Bioavailability is increased if drug is
given with food (Plumb 2011).
• Fat in foods does not alter
bioavailability of the drug much
(Plumb 2011).
• Fenbendazole is a
methylcarbonate benzimidazole
antiparasitic and has a broad
spectrum of activity against
pathogenic parasites (Plumb 2011).
•
Mechanism of action is said to be
the disruption of intracellular
microtubular transport systems
binding selectively and damaging
tubulin, preventing tubulin
polymerization, and inhibiting
microtubular formation (Plumb
2011).
 Acts at a higher concentrations to
interfere with metabolic pathways
within helminths, and inhibit
metabolic enzymes (Plumb 2011).
 Time dependent antiparasitic agent
(Plumb 2011).
 Fenbendazole is excreted from the intestinal tract.
 It is known for it’s ability to kill intestinal parasites
slowly.
 Time-dependent, bactericidal agent that inhibits cell




wall synthesis (Plumb 2011).
Is absorbed better orally.
Relatively stable in gastric acid.
Food will decrease the rate of absorption, but not the
extent of oral absorption.
The drug is distributed to tissues, liver, lungs, muscle,
bile, ascitic, pleural and synovial fluids.
 Eliminated through the kidneys through tubular
secretion.
 Some of the drug can be eliminated in the urine.
Fenbendazole Suspension
Amoxicillin Suspension
 This drug is known as an agonist
 This drug is known to be an
because it binds to tubulin and
damages it.
 This prevents tubulin
polymerization and inhibits
microtubule formation (Plumb
2011).
antagonist , beta-lactam
antibiotics bind to enzymes
within cytoplasmic membrane
that involve cell wall synthesis
(Plumb 2011).
 The drug inhibits or blocks cell
wall synthesis of actively
growing bacteria (Plumb 2011).
Scrappy is given:
 Fenbendazole for 3 consecutive days SID for treatment
of Trichuris vulpis.
 Amoxicillin for 10 days BID for secondary infection due
to the intestinal parasite Trichuris vulpis.
 Scrappy will return in two weeks to recheck fecal
floatation to make sure he is free of intestinal
parasites.
Plumb, Donald C.,(2011).Plumb’s Veterinary Drug
Handbook 7th Edition, Pharm Vet Inc.
Romich, Janet A.,(2010).Fundamentals of Pharmacology
for Veterinary Technicians Second Edition.Delmar