Download Cornelius J. Clancy, MD

Name:
Title:
Division:
Cornelius J. Clancy, MD
Associate Professor of Medicine
Infectious Diseases
Primary Email:
[email protected]
Assistant:
Primary Email:
Tanya Gonzales
[email protected]
Phone number:
412-648-8510
Key questions defining research program:
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What are mechanisms of antifungal resistance in Candida?
What are mechanisms of antibacterial resistance in Enterobacteriaceae?
What are roles of new drugs against highly-resistant Gram negative infections?
What is the distribution and effectiveness of antimicrobials at tissue sites of infection?
What is the epidemiology of Legionella in the water system and as a cause of disease in a
hospital complex?
Key words describing research program:
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Candida
Invasive candidiasis
Carbapenem resistant Enterobacteriaceae
Antimicrobial resistant bacteria and fungi
Legionella
Titles for shovel-ready research projects:
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Invasive fungal infections, including studies on epidemiology, emerging mold infections among
the non-traditional non-immunocompromised hosts, diagnostics, antifungal resistance, and
molecular mechanisms and animal models of pathogenesis
2) Non-cultural diagnostics for mold infection
3) In vitro antifungal susceptibility testing of isavuconazole against yeast and molds
4) Extensively-drug resistant Gram negative infections, including studies on epidemiology, devising
and implementing optimal treatment strategies, molecular mechanisms and evolution of
resistance, animal models of infection, and association between resistance and virulence
5) Evaluation of novel antibiotics (currently in Phase 2-3 clinical trials) against carbepenem-resistant
Gram negative. Drugs in the pipeline include imipenem-relabactam, meropenem-vaborbactam, etc.
6) Induction of resistance to novel antibiotics in vitro against CRE, and evaluation of mechanisms of
resistance
7) Infections in transplant recipients, including studies on host microbiomes during colonization and
disease states
8) Antimicrobial stewardship, including studies on patient outcomes and economic impact of
intervention strategies
9) Legionella and water system management, including studies on infection prevention, Legionella
genomic epidemiology, and water system microbiomes
10) A wide range of infection prevention projects around Legionnaires disease and
surveillance/prevention efforts at VA Pittsburgh, using unique databases in place at VAPHS
Data sources for shovel-ready research projects:
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Candida database and strain repository
Gram negative database and strain repository
Legionella database and strain repository
VA Infection Control Program databases
Mouse models of infection and antimicrobial resistance