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THE 11TH ANNUAL INTERNATIONAL SYMPOSIUM OF THE MERCK-FROSST / CIHR OBESITY RESEARCH CHAIR OBESITY IN A MODERN WORLD WHEN PLEASURE MEETS HOMEOSTASIS Wednesday Nov. 5, 2008, Québec Auberge Saint-Antoine Chaired by Denis Richard, Québec, Canada Session 1: Neurosystems Linking Homeostatic and Hedonic Pathways Involved in Energy Balance Regulation Chair: Fulton, S (Canada) 8:30 Berthoud, HR (USA) — Appetite Control and Energy Balance Regulation in the Modern World— Plenary 9:15 Leinninger, G (USA) — Leptin acts via neurotensin-containing lateral hypothalamic leptin receptor neurons to regulate the mesolimbic dopamine system and feeding 10:15 DiMarzo, V (Italy)— Endocannabinoids and cannabinoid receptors 1 as a link between reward and energy homeostasis 11:00 DiLeone R (USA): Integrating molecules and neural circuits controlling food intake and drug addiction 11:45 Discussion Session 2: From Taste to Reward, Motivation and Addiction. Chair: Dagher, A (Canada) 1:30pm Simon, S (USA) — The gustatory system and multisensory integration 2:15pm Small, D (USA): Neurophysiological risk factors for overeating: Teasing apart cause and effect by neuroimaging food reward 3:15pm Davis, C (Canada): Psychobiological Traits in the Risk Profile for Overeating and Weight Gain 4:00pm Levine, A (USA) —Reward system Regulation of Food Intake— Plenary 4:45pm Discussion