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Cancer Treat Rev. 2014 Apr;40(3):356-65. doi: 10.1016/j.ctrv.2013.11.010. Epub 2013 Dec 6.
Recent developments and current concepts in medulloblastoma.
Gerber NU1, Mynarek M2, von Hoff K3, Friedrich C4, Resch A5, Rutkowski S6.
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Abstract
Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has
significantly improved in the last decades with multimodal therapy including surgery, radiotherapy,
and chemotherapy, one third of patients still succumb to their disease. Further research is needed to
find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize
long-term sequelae of tumor treatment. This review gives a summary of the current state of
treatment concepts including an outlook on the near future. We describe recent advances in the
understanding of molecular mechanisms, their potential impact on risk stratification in upcoming
clinical trials, and perspectives for the clinical implementation of targeted therapies.
Copyright © 2013 Elsevier Ltd. All rights reserved.
KEYWORDS: (MeSH): Medulloblastoma, Brain neoplasms, Cancer, Child, Molecular targeted therapy,
Therapy
PMID: 24389035 [PubMed - indexed for MEDLINE]
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24/04/2014 10.51