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Session Description A New Paradigm for Depression in New Mothers Kathleen Kendall-Tackett, Ph.D., IBCLC Recent research has revealed that systemic inflammation, the immune system response to physical or psychological threat, increases the risk of depression. Puerperal women are especially vulnerable because proinflammatory cytokines significantly increase during the last trimester of pregnancy, the time when women are most at risk for depression, and continues on through the postpartum period. In addition, common experiences of new motherhood, such as sleep deprivation, postpartum pain, and psychological trauma, also cause inflammation levels to rise. This session will describe the inflammatory response and its relation to physical and psychological stress. This session will also show why breastfeeding and anti-inflammatory treatments, such as Omega-3s, cognitive therapy and antidepressants, protect maternal mental health by lowering the inflammatory response.