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MEDICAL ADVANCES
AS A RESULT OF WAR
James Cole, DO, FACS
Assistant Director of Trauma Services
Advocate Medical Group
Advocate Good Samaritan Hospital
Downers Grove, IL
Medical Advances as a Result of War
Prior to Current Wars
Blood Program
Variolation &
Immunization
Gangrene Treatment
Necrotizing War
Wound Treatment
Cautery
Food Preservation
General Anesthesia
Ligatures
Helicopter
Evacuation
Antisepsis
Tourniquet
Vascular
Surgery
Credentialing
Ambulance
Shock Treatment
Paramedics
 Surgery = extremity
amputation of major
extremity war wounds
 Cautery of bleeding
stumps
 Application of red-hot
heated irons
 Pouring on of boiling oil
 French military surgeon
 1510 - 1590
 Author of “Treatment
Method for Wounds and
Fractures of the Human
Head” (Henri II)
 Authority on battlefield
wounds and amputations
 Egg yolk, rose oil, and
turpentine rather than
boiling oil to treat GSWs
 Reintroduced ligatures
THE REVOLUTIONARY WAR
50,000 Deaths
 Small Pox spread
epidemically among
soldiers
 General Washington
ordered troop variolation
 Troops became ill for
weeks
 Many deaths prevented
 160/1,000  3/1,000
 Beginning of mass
immunization
 Most extremities were amputated
 To prevent future infection
 Pain Control
 Officers: Rum and Brandy
 Enlisted: Stick to bite upon
 Amputation Procedure
1718 Louis Petit
 Patient held down by two Surgeon’s Mates
 Tourniquet applied four fingers above wound
 Surgeon’s knife swiftly cut through muscle to bone
 Hand saw used to cut bone
 Bleeding stump dressed
 35% survival rate
 Baron Dominique Larrey
 Napoleon's Surgeon
 The “Flying Ambulances”
 Rapid evacuation of
casualties
 First aid supplies
 Advancements in field
amputation
 Early amputation
 Creation of flaps
 Avoidance of putrefying
agents
 Food often spoiled




during campaigns
Food-borne illness
recognized
Smoking / drying
insufficient
French Army prize for
food preservation
Appert developed
“canning” in 1810
Nicholas Appert
THE CIVIL WAR 1861 - 1865
625,000 deaths
 Inhalational sulfuric
ether invented in 1846
 Chloroform 1847
 Chloroform officially
issued to military doctors
 Union and Confederate
 “Painless surgery” on the
civil war battlefield
 8,900 documented uses
 37 deaths due to
Chloroform overdose
 Surgeon General J.K.
Barnes, M.D.
 Collapse after a blow to
abdomen (without a
wound) may be due to
“wound shock” from
internal bleeding.
 “The collapse of bleeding
resembles syncope.”
“Rest in bed, opium, and
warm formentations
constitute treatment.”
 Louis Pasteur in 1861
identification of bacterial
cause of putrefaction
 Erysipelas and “hospital
gangrene” common
 Mortality if untreated
~ 50%
 Topical Bromine
 Used to kill bacteria
 ↓ Mortality to 2.6%
 Dr. John Letterman
 Each regiment assigned
3 ambulance teams
 2 Privates
 1 Driver
 Ambulance supplies
 1 quart flask of brandy
 2 tourniquets
 6 bandages
 6 small sponges
 Splint material
 Pieces of old blankets
 Jonathan Letterman, MD
 Union Surgeon
 Confederates similar
order
 Ordered only
experienced surgeons
perform amputations
 3 top Surgeons per
Division
 Documented experience
and competence
 “Medical and Surgical
History of the War of the
Rebellion”
 6 volume publication of
civil war injury, disease,
and treatment
 Lt. Col. Joseph
Woodward, MD
 Principle author
 Performed Lincoln
autopsy
THE SPANISH-AMERICAN WAR
~2,500 deaths
 Spanish-American War –
first war fought across
the ocean
 Malaria, yellow fever,
dengue fever, and
amoebic dysentery
 Maj Walter Reed
established the
relationship of
mosquitoes and Yellow
Fever
 Mosquito control began
 Sir Joseph Lister
 Discovery of antisepsis in




1867
Use of aerosolized carbolic
acid in surgery
Antiseptic surgery and
topical antiseptics used
widely in Spanish-Am War
Antiseptics in first aid kits
issued to all soldiers
Significant ↓ in wound deaths
WORLD WAR I
116,000 Deaths
 Horrific trench warfare
 Better weapons  more casualties
 Better understanding of “shock”
 Recognition of temporary effect of crystalloid
 Tissue third spacing
 Development of “Gum Salt”
 6% acacia plus salt solution
 Improved blood pressure with “Gum Salt”
 High incidence of fever and other reactions
 Motorized ambulance
 Whole blood transfusion
 Widely used during WWI
 Recognized effectiveness of raising BP and ↑ O2 delivery
 Small volumes administered ≤ 600 ml
 Fresh, warm blood given within 2 hours of donation
 Found to be very effective
 Elevation of feet
 Recognition of hypoxia – cyanotic appearance
 No method for oxygen administration
 Use of vasopressors (epinephrine) condemned
 Mr. George Grey Turner
 British War Surgeon
 First surgical attempt to retrieve an intracardiac bullet
 Bullet seen in heart on x-ray
 Heart exposed through left chest
 Bullet palpated lodged in septum. Not removed.
 Drain placed
 Pericardium sutured
 Casualty survived
 The birth of cardiac surgery
 Expectant management
 High mortality for
persistent hemorrhage
 Lord Moynihan of Leeds
 British War Surgeon
 Introduced thoracotomy
for persistent bleeding
 Improved survival rates
 Endotracheal tubes not
in general use
 Catastrophic outcomes
 Recognized need for
extensive tissue
debridement
 Inter-Allied Surgical
Conference of 1917
 Extensive debridement
 Closure by secondary
intention
 “4 C’s of Muscle Viability”
 Contraction, color,
 Consistency, capillaries
Sir Henry Simpson Newland
Australian Surgeon WWI
WORLD WAR II
407,000 Deaths
 MG Norman Kirk
 Management of
Extremity War Wounds
 Open circular
amputation
 Close by secondary
intention
 Colonic Injuries
 Diverting colostomy
 Mortality ↓ to 24%
 Significant inter-war setbacks
 Lessons learned in WWI largely forgotten
 Normal saline in limited availability
“A spoonful of salt was added to distilled water, placed in a
Salversan flask attached to an old rubber tube and
needle.”
 Tube sterile, but pyrogens caused fevers > 105˚
 Need for large volume fluid infusion forgotten
 Benefits of blood initially forgotten
 Plasma infusion the initial fluid of choice
 Shipment of blood to remote areas impractical
 Col Douglas Kendrick
 Surgical Consultant
 North African Theater
 Reinstituted use of whole
blood for blood loss
 Developed the Army
Blood Program
 Theater wide
distribution of whole
blood
 Forefather of regional
blood banks
 “Battle Fatigue”
 “Shell Shock”
 Recognized mental
effects of the exposure to
war
 Unprecedented studies
 Aggressive push for
outpatient care
 The beginnings of “Post
Traumatic Stress
Disorder” care
The Korean War
36,000 deaths
 Brought surgical casualty
management to the front
 CPT H. Richard Hornberger,
Surgeon
 “Meatball Surgery”
 Patch the casualties up
 Save lives
 Ship them to US for
definitive care
 Unprecedented salvage
 Absence of military bearing
 Nurses in combat hospitals
 3 – 4 Bell H-13 Sioux
helicopters per MASH
 Rapid CASEVAC – 10
miles
 Features
 Stretcher pod on skids
 “Goldfish bowl” Plexiglas
canopy
 Heat piping into litter
areas
 IV mounts on outside
 Amputation no longer




always necessary
Direct vascular repair
Arterial replacement
Col Michael Debakey
Significant reduction in
casualty amputation rate
The Vietnam War
58,000 Deaths
 Life-saving emergency
care pushed to the front
lines
 Surgical airways
 Chest needle
decompression
 Aggressive shock
resuscitation
 Beginnings of civilian
pre-hospital EMS
OPERATION RESTORE HOPE -- 1993
 Blackhawk helicopter crash
 Maj John Holcomb
 Surgeon – operated 30
consecutive hours
 18 deaths in field
 2 “potentially preventable”
 Exsanguination
hemorrhage
 Research on hemostatic
bandage technology
 Dry Fibrin Sealant (DFS)
 Fibrinogen, thrombin, Ca
 Activated by water
 Brittle, expensive
 QuikClot
 Zeolite powder
 Drying agent
 Exothermic reaction
 Hemcon
 Chitosan
 Local vasoconstrictor
THE PAST DECADE
OF WARS
In Iraq and Afghanistan
“Only do that which is
necessary to save the life of
the casualty…”
 Surgery
 Control hemorrhage
 Control soilage
 Prevent the “Lethal Triad”
 Resuscitate in “ICU”
 Take-back when stable
 Significant ↑ in survival
 DOW rate 0.8%
 Massive brain trauma
 “Compartment
syndrome” of the head
 Analogy: Fasciotomy
 Use in malignant
intracranial hypertension
 Increased survival
 ABC reporter Bob
Woodward
 Combat Application
Tourniquet – 2
 Prevention of extremity
hemorrhage
 Unstable  stable
 Negligible incidence of
limb loss from tourniquet
 Characteristics
 2 inches
 Windlass
 Cessation of pulse
 NovoSeven
 Hemophilia
 War experience Israel
 War experience Iraq
 Critics
 ↑ thrombotic
complications
 Advocates
 ↑ survival in multiple
trauma
 “Flying ICUs”
 Large military aircraft
 Critical Care staff
 Pulmonologists, CCRNs,
RTs, corpsmen/medics
 Critical care equipment
 Blood
 Critical care medications
 Evacuation war zone 
Landstuhl  U.S.
 Limited availability FFP,
platelets, cryoprecipitate
 pRBCs and saline
 Cold, old, no clotting
factors / platelets
 Fresh, warm, whole blood
 FFP, cryo, platelets
 Extensively used in Iraq
 Thousands of units given
 Countless lives saved
 Transfusion reactions rare
 Extensive blast injuries
 New reconstructive
methods
 IED to hand  complete
loss of metacarpals and
hand tendons
 Reconstruction with ribs
and serratus flap
 Versajet high pressure
saline debridement
 Less tissue loss
 Fewer debridements
 Better graft take
 Wound Vac therapy
 Decreases healing time
 Earlier transport
between institutions
 Multiple wounds to
multiple body parts
 Multiple surgeries and
anesthetics
 Creative use of local and
regional anesthesia
 Research on treatment of
phantom limb pain
 1:30 combat vets 




amputee
Defense Advanced
Research Projects Agency
Electrocortography brain
mapping grids
Use of brain signals to
trigger prosthetics
“House legs” for mobility
in the home
Military Medicine
“Binding the Wounds of War”
Dedicated to the Memory of John Pryor, MD
Major, Medical Corps, US Army Reserve
Trauma Surgeon, University of Pennsylvania
Killed in Action
December 25, 2008
Mosul, Iraq